Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
العنوان: | Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways |
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المؤلفون: | Brian T. Fife, Jeffrey A. Bluestone |
المصدر: | Immunological reviews. 224 |
سنة النشر: | 2008 |
مصطلحات موضوعية: | Immunoconjugates, T cell, T-Lymphocytes, Immunology, Programmed Cell Death 1 Receptor, chemical and pharmacologic phenomena, Autoimmunity, Biology, Lymphocyte Activation, Immune tolerance, Autoimmune Diseases, Abatacept, Immune system, Antigens, CD, PD-L1, medicine, Immune Tolerance, Immunology and Allergy, Animals, Humans, CTLA-4 Antigen, Clonal Anergy, Peripheral tolerance, CD28, Antibodies, Monoclonal, hemic and immune systems, Cell biology, medicine.anatomical_structure, CTLA-4, biology.protein, Immunotherapy, Signal transduction, Apoptosis Regulatory Proteins, Signal Transduction |
الوصف: | Classically, the CD28/cytotoxic T-lymphocyte antigen-4 (CTLA-4) and B7 families of cell surface molecules regulate complex signaling pathways that profoundly affect T-cell responses. The recent identification and characterization of additional CD28 and B7 family members including programmed death-1 (PD-1), programmed death ligand-1 (PD-L1) (B7-H1), and PD-L2 (B7-DC) has added to the complexity and greater appreciation of how surface molecules control T-cell activation and peripheral tolerance. CD28/B7 interactions mediate co-stimulation and significantly enhance peripheral T-cell responses. CTLA-4, in contrast, interacting with the same B7 molecules, results in decreased T-lymphocyte activity and regulates the immune response. Similarly, PD-1 interactions with PD-L1 and PD-L2 downmodulate T-cell immune responses. Despite these similarities, the regulatory roles of the CTLA-4 and PD-1 pathways are distinct. This may be due, at least in part, to the differential expression patterns of the CTLA-4 and PD-1 ligands both temporally and spatially. This article examines the role of CTLA-4 and PD-1 in limiting autoreactivity and establishing peripheral self-tolerance with the hypothesis that CTLA-4 signals are required early in the lymph node during initiation of an immune response and PD-1 pathways act late at the tissue sites to limit T-cell activity. |
تدمد: | 1600-065X |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b08616540a912c55537344ae516a1Test https://pubmed.ncbi.nlm.nih.gov/18759926Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....c21b08616540a912c55537344ae516a1 |
قاعدة البيانات: | OpenAIRE |