Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
| العنوان: | Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways |
|---|---|
| المؤلفون: | Brian T. Fife, Jeffrey A. Bluestone |
| المصدر: | Immunological reviews. 224 |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Immunoconjugates, T cell, T-Lymphocytes, Immunology, Programmed Cell Death 1 Receptor, chemical and pharmacologic phenomena, Autoimmunity, Biology, Lymphocyte Activation, Immune tolerance, Autoimmune Diseases, Abatacept, Immune system, Antigens, CD, PD-L1, medicine, Immune Tolerance, Immunology and Allergy, Animals, Humans, CTLA-4 Antigen, Clonal Anergy, Peripheral tolerance, CD28, Antibodies, Monoclonal, hemic and immune systems, Cell biology, medicine.anatomical_structure, CTLA-4, biology.protein, Immunotherapy, Signal transduction, Apoptosis Regulatory Proteins, Signal Transduction |
| الوصف: | Classically, the CD28/cytotoxic T-lymphocyte antigen-4 (CTLA-4) and B7 families of cell surface molecules regulate complex signaling pathways that profoundly affect T-cell responses. The recent identification and characterization of additional CD28 and B7 family members including programmed death-1 (PD-1), programmed death ligand-1 (PD-L1) (B7-H1), and PD-L2 (B7-DC) has added to the complexity and greater appreciation of how surface molecules control T-cell activation and peripheral tolerance. CD28/B7 interactions mediate co-stimulation and significantly enhance peripheral T-cell responses. CTLA-4, in contrast, interacting with the same B7 molecules, results in decreased T-lymphocyte activity and regulates the immune response. Similarly, PD-1 interactions with PD-L1 and PD-L2 downmodulate T-cell immune responses. Despite these similarities, the regulatory roles of the CTLA-4 and PD-1 pathways are distinct. This may be due, at least in part, to the differential expression patterns of the CTLA-4 and PD-1 ligands both temporally and spatially. This article examines the role of CTLA-4 and PD-1 in limiting autoreactivity and establishing peripheral self-tolerance with the hypothesis that CTLA-4 signals are required early in the lymph node during initiation of an immune response and PD-1 pathways act late at the tissue sites to limit T-cell activity. |
| تدمد: | 1600-065X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b08616540a912c55537344ae516a1Test https://pubmed.ncbi.nlm.nih.gov/18759926Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c21b08616540a912c55537344ae516a1 |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....c21b08616540a912c55537344ae516a1 766 3 unknown 765.770812988281 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....c21b08616540a912c55537344ae516a1&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Brian+T%2E+Fife%22">Brian T. Fife</searchLink><br /><searchLink fieldCode="AR" term="%22Jeffrey+A%2E+Bluestone%22">Jeffrey A. Bluestone</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Immunological reviews</i>. 224 ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2008 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Immunoconjugates%22">Immunoconjugates</searchLink><br /><searchLink fieldCode="DE" term="%22T+cell%22">T cell</searchLink><br /><searchLink fieldCode="DE" term="%22T-Lymphocytes%22">T-Lymphocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Programmed+Cell+Death+1+Receptor%22">Programmed Cell Death 1 Receptor</searchLink><br /><searchLink fieldCode="DE" term="%22chemical+and+pharmacologic+phenomena%22">chemical and pharmacologic phenomena</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmunity%22">Autoimmunity</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocyte+Activation%22">Lymphocyte Activation</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+tolerance%22">Immune tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmune+Diseases%22">Autoimmune Diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Abatacept%22">Abatacept</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+system%22">Immune system</searchLink><br /><searchLink fieldCode="DE" term="%22Antigens%2C+CD%22">Antigens, CD</searchLink><br /><searchLink fieldCode="DE" term="%22PD-L1%22">PD-L1</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+Tolerance%22">Immune Tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology+and+Allergy%22">Immunology and Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22CTLA-4+Antigen%22">CTLA-4 Antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Clonal+Anergy%22">Clonal Anergy</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+tolerance%22">Peripheral tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22CD28%22">CD28</searchLink><br /><searchLink fieldCode="DE" term="%22Antibodies%2C+Monoclonal%22">Antibodies, Monoclonal</searchLink><br /><searchLink fieldCode="DE" term="%22hemic+and+immune+systems%22">hemic and immune systems</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+biology%22">Cell biology</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22CTLA-4%22">CTLA-4</searchLink><br /><searchLink fieldCode="DE" term="%22biology%2Eprotein%22">biology.protein</searchLink><br /><searchLink fieldCode="DE" term="%22Immunotherapy%22">Immunotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Signal+transduction%22">Signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis+Regulatory+Proteins%22">Apoptosis Regulatory Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Signal+Transduction%22">Signal Transduction</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Classically, the CD28/cytotoxic T-lymphocyte antigen-4 (CTLA-4) and B7 families of cell surface molecules regulate complex signaling pathways that profoundly affect T-cell responses. The recent identification and characterization of additional CD28 and B7 family members including programmed death-1 (PD-1), programmed death ligand-1 (PD-L1) (B7-H1), and PD-L2 (B7-DC) has added to the complexity and greater appreciation of how surface molecules control T-cell activation and peripheral tolerance. CD28/B7 interactions mediate co-stimulation and significantly enhance peripheral T-cell responses. CTLA-4, in contrast, interacting with the same B7 molecules, results in decreased T-lymphocyte activity and regulates the immune response. Similarly, PD-1 interactions with PD-L1 and PD-L2 downmodulate T-cell immune responses. Despite these similarities, the regulatory roles of the CTLA-4 and PD-1 pathways are distinct. This may be due, at least in part, to the differential expression patterns of the CTLA-4 and PD-1 ligands both temporally and spatially. This article examines the role of CTLA-4 and PD-1 in limiting autoreactivity and establishing peripheral self-tolerance with the hypothesis that CTLA-4 signals are required early in the lymph node during initiation of an immune response and PD-1 pathways act late at the tissue sites to limit T-cell activity. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1600-065X ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b08616540a912c55537344ae516a1" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b08616540a912c55537344ae516a1</link><br /><link linkTarget="URL" linkTerm="https://pubmed.ncbi.nlm.nih.gov/18759926" linkWindow="_blank">https://pubmed.ncbi.nlm.nih.gov/18759926</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => CLOSED ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....c21b08616540a912c55537344ae516a1 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Immunoconjugates
[Type] => general
)
[1] => Array
(
[SubjectFull] => T cell
[Type] => general
)
[2] => Array
(
[SubjectFull] => T-Lymphocytes
[Type] => general
)
[3] => Array
(
[SubjectFull] => Immunology
[Type] => general
)
[4] => Array
(
[SubjectFull] => Programmed Cell Death 1 Receptor
[Type] => general
)
[5] => Array
(
[SubjectFull] => chemical and pharmacologic phenomena
[Type] => general
)
[6] => Array
(
[SubjectFull] => Autoimmunity
[Type] => general
)
[7] => Array
(
[SubjectFull] => Biology
[Type] => general
)
[8] => Array
(
[SubjectFull] => Lymphocyte Activation
[Type] => general
)
[9] => Array
(
[SubjectFull] => Immune tolerance
[Type] => general
)
[10] => Array
(
[SubjectFull] => Autoimmune Diseases
[Type] => general
)
[11] => Array
(
[SubjectFull] => Abatacept
[Type] => general
)
[12] => Array
(
[SubjectFull] => Immune system
[Type] => general
)
[13] => Array
(
[SubjectFull] => Antigens, CD
[Type] => general
)
[14] => Array
(
[SubjectFull] => PD-L1
[Type] => general
)
[15] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[16] => Array
(
[SubjectFull] => Immune Tolerance
[Type] => general
)
[17] => Array
(
[SubjectFull] => Immunology and Allergy
[Type] => general
)
[18] => Array
(
[SubjectFull] => Animals
[Type] => general
)
[19] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[20] => Array
(
[SubjectFull] => CTLA-4 Antigen
[Type] => general
)
[21] => Array
(
[SubjectFull] => Clonal Anergy
[Type] => general
)
[22] => Array
(
[SubjectFull] => Peripheral tolerance
[Type] => general
)
[23] => Array
(
[SubjectFull] => CD28
[Type] => general
)
[24] => Array
(
[SubjectFull] => Antibodies, Monoclonal
[Type] => general
)
[25] => Array
(
[SubjectFull] => hemic and immune systems
[Type] => general
)
[26] => Array
(
[SubjectFull] => Cell biology
[Type] => general
)
[27] => Array
(
[SubjectFull] => medicine.anatomical_structure
[Type] => general
)
[28] => Array
(
[SubjectFull] => CTLA-4
[Type] => general
)
[29] => Array
(
[SubjectFull] => biology.protein
[Type] => general
)
[30] => Array
(
[SubjectFull] => Immunotherapy
[Type] => general
)
[31] => Array
(
[SubjectFull] => Signal transduction
[Type] => general
)
[32] => Array
(
[SubjectFull] => Apoptosis Regulatory Proteins
[Type] => general
)
[33] => Array
(
[SubjectFull] => Signal Transduction
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Brian T. Fife
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jeffrey A. Bluestone
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 02
[M] => 09
[Type] => published
[Y] => 2008
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 1600065X
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 224
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Immunological reviews
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |