Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation
| العنوان: | Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation |
|---|---|
| المؤلفون: | Kathryn V. Holmes, Onder Alpdogan, Marcel R.M. van den Brink, George F. Murphy, Olaf Penack, Fernando Macian, Chen Liu, Amanda M. Holland, Nicole Beauchemin, Uttam K. Rao, Marsinay Smith, Renée Atallah, David Suh, Jimmy A. Rotolo, Johanne L. Bautista, Sydney X. Lu, Claire Turbide, Lucy W. Kappel, Vanessa M. Hubbard, Anne Marie Charbonneau-Allard, Nury L. Yim, Christopher R. King, Robert R. Jenq, Il-Kang Na, Richard S. Blumberg |
| المصدر: | PLoS ONE PLoS ONE, Vol 6, Iss 7, p e21611 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, Cancer Research, Integrins, Graft vs Host Disease, lcsh:Medicine, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Inflammatory bowel disease, Mice, 0302 clinical medicine, Carcinoembryonic antigen, immune system diseases, Radiation, Ionizing, Intestine, Small, Cytotoxic T cell, Bone Marrow and Stem Cell Transplantation, lcsh:Science, Immune Response, Bone Marrow Transplantation, 0303 health sciences, Multidisciplinary, biology, Cell adhesion molecule, T Cells, Graft vs Tumor Effect, Cell Polarity, Hematology, General Medicine, 3. Good health, Radiation Injuries, Experimental, surgical procedures, operative, Organ Specificity, 030220 oncology & carcinogenesis, Experimental pathology, Medicine, medicine.symptom, General Agricultural and Biological Sciences, Research Article, Tumor Immunology, Lymphoid Tissue, Immune Cells, Immunology, Inflammation, General Biochemistry, Genetics and Molecular Biology, Immunomodulation, 03 medical and health sciences, medicine, Animals, Humans, Transplantation, Homologous, Lymphocyte Count, Biology, 030304 developmental biology, Cell Proliferation, Transplantation, lcsh:R, Dendritic Cells, Immunologic Subspecialties, medicine.disease, Carcinoembryonic Antigen, Graft-versus-host disease, biology.protein, lcsh:Q |
| الوصف: | Background: Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regulates a variety of physiologic and pathological processes such as tumor biology, leukocyte activation, and energy homeostasis. Previous studies suggest that Ceacam1 negatively regulates inflammation in inflammatory bowel disease models. Methods: We studied Ceacam1 as a regulator of GVHD and GVT after allogeneic bone marrow transplantation (allo-BMT) in mouse models. In vivo, Ceacam1(-/-) T cells caused increased GVHD mortality and GVHD of the colon, and greater numbers of donor T cells were positive for activation markers (CD25(hi), CD62L(lo)). Additionally, Ceacam1(-/-) CD8 T cells had greater expression of the gut-trafficking integrin α(4)β(7), though both CD4 and CD8 T cells were found increased numbers in the gut post-transplant. Ceacam1(-/-) recipients also experienced increased GVHD mortality and GVHD of the colon, and alloreactive T cells displayed increased activation. Additionally, Ceacam1(-/-) mice had increased mortality and decreased numbers of regenerating small intestinal crypts upon radiation exposure. Conversely, Ceacam1-overexpressing T cells caused attenuated target-organ and systemic GVHD, which correlated with decreased donor T cell numbers in target tissues, and mortality. Finally, graft-versus-tumor survival in a Ceacam1(+) lymphoma model was improved in animals receiving Ceacam1(-/-) vs. control T cells. Conclusions: We conclude that Ceacam1 regulates T cell activation, GVHD target organ damage, and numbers of donor T cells in lymphoid organs and GVHD target tissues. In recipients of allo-BMT, Ceacam1 may also regulate tissue radiosensitivity. Because of its expression on both the donor graft and host tissues, this suggests that targeting Ceacam1 may represent a potent strategy for the regulation of GVHD and GVT after allogeneic transplantation. |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0021611 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ab1cdb44e9ab41d505f41ce8cb0f5dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0ab1cdb44e9ab41d505f41ce8cb0f5d |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....c0ab1cdb44e9ab41d505f41ce8cb0f5d 770 3 unknown 769.734741210938 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....c0ab1cdb44e9ab41d505f41ce8cb0f5d&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Kathryn+V%2E+Holmes%22">Kathryn V. Holmes</searchLink><br /><searchLink fieldCode="AR" term="%22Onder+Alpdogan%22">Onder Alpdogan</searchLink><br /><searchLink fieldCode="AR" term="%22Marcel+R%2EM%2E+van+den+Brink%22">Marcel R.M. van den Brink</searchLink><br /><searchLink fieldCode="AR" term="%22George+F%2E+Murphy%22">George F. Murphy</searchLink><br /><searchLink fieldCode="AR" term="%22Olaf+Penack%22">Olaf Penack</searchLink><br /><searchLink fieldCode="AR" term="%22Fernando+Macian%22">Fernando Macian</searchLink><br /><searchLink fieldCode="AR" term="%22Chen+Liu%22">Chen Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Amanda+M%2E+Holland%22">Amanda M. Holland</searchLink><br /><searchLink fieldCode="AR" term="%22Nicole+Beauchemin%22">Nicole Beauchemin</searchLink><br /><searchLink fieldCode="AR" term="%22Uttam+K%2E+Rao%22">Uttam K. Rao</searchLink><br /><searchLink fieldCode="AR" term="%22Marsinay+Smith%22">Marsinay Smith</searchLink><br /><searchLink fieldCode="AR" term="%22Renée+Atallah%22">Renée Atallah</searchLink><br /><searchLink fieldCode="AR" term="%22David+Suh%22">David Suh</searchLink><br /><searchLink fieldCode="AR" term="%22Jimmy+A%2E+Rotolo%22">Jimmy A. Rotolo</searchLink><br /><searchLink fieldCode="AR" term="%22Johanne+L%2E+Bautista%22">Johanne L. Bautista</searchLink><br /><searchLink fieldCode="AR" term="%22Sydney+X%2E+Lu%22">Sydney X. Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Claire+Turbide%22">Claire Turbide</searchLink><br /><searchLink fieldCode="AR" term="%22Lucy+W%2E+Kappel%22">Lucy W. Kappel</searchLink><br /><searchLink fieldCode="AR" term="%22Vanessa+M%2E+Hubbard%22">Vanessa M. Hubbard</searchLink><br /><searchLink fieldCode="AR" term="%22Anne+Marie+Charbonneau-Allard%22">Anne Marie Charbonneau-Allard</searchLink><br /><searchLink fieldCode="AR" term="%22Nury+L%2E+Yim%22">Nury L. Yim</searchLink><br /><searchLink fieldCode="AR" term="%22Christopher+R%2E+King%22">Christopher R. King</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+R%2E+Jenq%22">Robert R. Jenq</searchLink><br /><searchLink fieldCode="AR" term="%22Il-Kang+Na%22">Il-Kang Na</searchLink><br /><searchLink fieldCode="AR" term="%22Richard+S%2E+Blumberg%22">Richard S. Blumberg</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => PLoS ONE<br />PLoS ONE, Vol 6, Iss 7, p e21611 (2011) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Public Library of Science (PLoS), 2011. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2011 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Cytotoxicity%2C+Immunologic%22">Cytotoxicity, Immunologic</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+Research%22">Cancer Research</searchLink><br /><searchLink fieldCode="DE" term="%22Integrins%22">Integrins</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+vs+Host+Disease%22">Graft vs Host Disease</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AMedicine%22">lcsh:Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22CD8-Positive+T-Lymphocytes%22">CD8-Positive T-Lymphocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocyte+Activation%22">Lymphocyte Activation</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+disease%22">Inflammatory bowel disease</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinoembryonic+antigen%22">Carcinoembryonic antigen</searchLink><br /><searchLink fieldCode="DE" term="%22immune+system+diseases%22">immune system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation%2C+Ionizing%22">Radiation, Ionizing</searchLink><br /><searchLink fieldCode="DE" term="%22Intestine%2C+Small%22">Intestine, Small</searchLink><br /><searchLink fieldCode="DE" term="%22Cytotoxic+T+cell%22">Cytotoxic T cell</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+Marrow+and+Stem+Cell+Transplantation%22">Bone Marrow and Stem Cell Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AScience%22">lcsh:Science</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+Response%22">Immune Response</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+Marrow+Transplantation%22">Bone Marrow Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%220303+health+sciences%22">0303 health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Multidisciplinary%22">Multidisciplinary</searchLink><br /><searchLink fieldCode="DE" term="%22biology%22">biology</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+adhesion+molecule%22">Cell adhesion molecule</searchLink><br /><searchLink fieldCode="DE" term="%22T+Cells%22">T Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+vs+Tumor+Effect%22">Graft vs Tumor Effect</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Polarity%22">Cell Polarity</searchLink><br /><searchLink fieldCode="DE" term="%22Hematology%22">Hematology</searchLink><br /><searchLink fieldCode="DE" term="%22General+Medicine%22">General Medicine</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+Injuries%2C+Experimental%22">Radiation Injuries, Experimental</searchLink><br /><searchLink fieldCode="DE" term="%22surgical+procedures%2C+operative%22">surgical procedures, operative</searchLink><br /><searchLink fieldCode="DE" term="%22Organ+Specificity%22">Organ Specificity</searchLink><br /><searchLink fieldCode="DE" term="%22030220+oncology+%26+carcinogenesis%22">030220 oncology & carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+pathology%22">Experimental pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Esymptom%22">medicine.symptom</searchLink><br /><searchLink fieldCode="DE" term="%22General+Agricultural+and+Biological+Sciences%22">General Agricultural and Biological Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Research+Article%22">Research Article</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+Immunology%22">Tumor Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphoid+Tissue%22">Lymphoid Tissue</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+Cells%22">Immune Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22General+Biochemistry%2C+Genetics+and+Molecular+Biology%22">General Biochemistry, Genetics and Molecular Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Immunomodulation%22">Immunomodulation</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Transplantation%2C+Homologous%22">Transplantation, Homologous</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocyte+Count%22">Lymphocyte Count</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22030304+developmental+biology%22">030304 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Proliferation%22">Cell Proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Transplantation%22">Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AR%22">lcsh:R</searchLink><br /><searchLink fieldCode="DE" term="%22Dendritic+Cells%22">Dendritic Cells</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+Subspecialties%22">Immunologic Subspecialties</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinoembryonic+Antigen%22">Carcinoembryonic Antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Graft-versus-host+disease%22">Graft-versus-host disease</searchLink><br /><searchLink fieldCode="DE" term="%22biology%2Eprotein%22">biology.protein</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AQ%22">lcsh:Q</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background: Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regulates a variety of physiologic and pathological processes such as tumor biology, leukocyte activation, and energy homeostasis. Previous studies suggest that Ceacam1 negatively regulates inflammation in inflammatory bowel disease models. Methods: We studied Ceacam1 as a regulator of GVHD and GVT after allogeneic bone marrow transplantation (allo-BMT) in mouse models. In vivo, Ceacam1(-/-) T cells caused increased GVHD mortality and GVHD of the colon, and greater numbers of donor T cells were positive for activation markers (CD25(hi), CD62L(lo)). Additionally, Ceacam1(-/-) CD8 T cells had greater expression of the gut-trafficking integrin α(4)β(7), though both CD4 and CD8 T cells were found increased numbers in the gut post-transplant. Ceacam1(-/-) recipients also experienced increased GVHD mortality and GVHD of the colon, and alloreactive T cells displayed increased activation. Additionally, Ceacam1(-/-) mice had increased mortality and decreased numbers of regenerating small intestinal crypts upon radiation exposure. Conversely, Ceacam1-overexpressing T cells caused attenuated target-organ and systemic GVHD, which correlated with decreased donor T cell numbers in target tissues, and mortality. Finally, graft-versus-tumor survival in a Ceacam1(+) lymphoma model was improved in animals receiving Ceacam1(-/-) vs. control T cells. Conclusions: We conclude that Ceacam1 regulates T cell activation, GVHD target organ damage, and numbers of donor T cells in lymphoid organs and GVHD target tissues. In recipients of allo-BMT, Ceacam1 may also regulate tissue radiosensitivity. Because of its expression on both the donor graft and host tissues, this suggests that targeting Ceacam1 may represent a potent strategy for the regulation of GVHD and GVT after allogeneic transplantation. ) Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1932-6203 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1371/journal.pone.0021611 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ab1cdb44e9ab41d505f41ce8cb0f5d" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ab1cdb44e9ab41d505f41ce8cb0f5d</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....c0ab1cdb44e9ab41d505f41ce8cb0f5d ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1371/journal.pone.0021611
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Cytotoxicity, Immunologic
[Type] => general
)
[1] => Array
(
[SubjectFull] => Cancer Research
[Type] => general
)
[2] => Array
(
[SubjectFull] => Integrins
[Type] => general
)
[3] => Array
(
[SubjectFull] => Graft vs Host Disease
[Type] => general
)
[4] => Array
(
[SubjectFull] => lcsh:Medicine
[Type] => general
)
[5] => Array
(
[SubjectFull] => CD8-Positive T-Lymphocytes
[Type] => general
)
[6] => Array
(
[SubjectFull] => Lymphocyte Activation
[Type] => general
)
[7] => Array
(
[SubjectFull] => Inflammatory bowel disease
[Type] => general
)
[8] => Array
(
[SubjectFull] => Mice
[Type] => general
)
[9] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[10] => Array
(
[SubjectFull] => Carcinoembryonic antigen
[Type] => general
)
[11] => Array
(
[SubjectFull] => immune system diseases
[Type] => general
)
[12] => Array
(
[SubjectFull] => Radiation, Ionizing
[Type] => general
)
[13] => Array
(
[SubjectFull] => Intestine, Small
[Type] => general
)
[14] => Array
(
[SubjectFull] => Cytotoxic T cell
[Type] => general
)
[15] => Array
(
[SubjectFull] => Bone Marrow and Stem Cell Transplantation
[Type] => general
)
[16] => Array
(
[SubjectFull] => lcsh:Science
[Type] => general
)
[17] => Array
(
[SubjectFull] => Immune Response
[Type] => general
)
[18] => Array
(
[SubjectFull] => Bone Marrow Transplantation
[Type] => general
)
[19] => Array
(
[SubjectFull] => 0303 health sciences
[Type] => general
)
[20] => Array
(
[SubjectFull] => Multidisciplinary
[Type] => general
)
[21] => Array
(
[SubjectFull] => biology
[Type] => general
)
[22] => Array
(
[SubjectFull] => Cell adhesion molecule
[Type] => general
)
[23] => Array
(
[SubjectFull] => T Cells
[Type] => general
)
[24] => Array
(
[SubjectFull] => Graft vs Tumor Effect
[Type] => general
)
[25] => Array
(
[SubjectFull] => Cell Polarity
[Type] => general
)
[26] => Array
(
[SubjectFull] => Hematology
[Type] => general
)
[27] => Array
(
[SubjectFull] => General Medicine
[Type] => general
)
[28] => Array
(
[SubjectFull] => 3. Good health
[Type] => general
)
[29] => Array
(
[SubjectFull] => Radiation Injuries, Experimental
[Type] => general
)
[30] => Array
(
[SubjectFull] => surgical procedures, operative
[Type] => general
)
[31] => Array
(
[SubjectFull] => Organ Specificity
[Type] => general
)
[32] => Array
(
[SubjectFull] => 030220 oncology & carcinogenesis
[Type] => general
)
[33] => Array
(
[SubjectFull] => Experimental pathology
[Type] => general
)
[34] => Array
(
[SubjectFull] => Medicine
[Type] => general
)
[35] => Array
(
[SubjectFull] => medicine.symptom
[Type] => general
)
[36] => Array
(
[SubjectFull] => General Agricultural and Biological Sciences
[Type] => general
)
[37] => Array
(
[SubjectFull] => Research Article
[Type] => general
)
[38] => Array
(
[SubjectFull] => Tumor Immunology
[Type] => general
)
[39] => Array
(
[SubjectFull] => Lymphoid Tissue
[Type] => general
)
[40] => Array
(
[SubjectFull] => Immune Cells
[Type] => general
)
[41] => Array
(
[SubjectFull] => Immunology
[Type] => general
)
[42] => Array
(
[SubjectFull] => Inflammation
[Type] => general
)
[43] => Array
(
[SubjectFull] => General Biochemistry, Genetics and Molecular Biology
[Type] => general
)
[44] => Array
(
[SubjectFull] => Immunomodulation
[Type] => general
)
[45] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[46] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[47] => Array
(
[SubjectFull] => Animals
[Type] => general
)
[48] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[49] => Array
(
[SubjectFull] => Transplantation, Homologous
[Type] => general
)
[50] => Array
(
[SubjectFull] => Lymphocyte Count
[Type] => general
)
[51] => Array
(
[SubjectFull] => Biology
[Type] => general
)
[52] => Array
(
[SubjectFull] => 030304 developmental biology
[Type] => general
)
[53] => Array
(
[SubjectFull] => Cell Proliferation
[Type] => general
)
[54] => Array
(
[SubjectFull] => Transplantation
[Type] => general
)
[55] => Array
(
[SubjectFull] => lcsh:R
[Type] => general
)
[56] => Array
(
[SubjectFull] => Dendritic Cells
[Type] => general
)
[57] => Array
(
[SubjectFull] => Immunologic Subspecialties
[Type] => general
)
[58] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[59] => Array
(
[SubjectFull] => Carcinoembryonic Antigen
[Type] => general
)
[60] => Array
(
[SubjectFull] => Graft-versus-host disease
[Type] => general
)
[61] => Array
(
[SubjectFull] => biology.protein
[Type] => general
)
[62] => Array
(
[SubjectFull] => lcsh:Q
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kathryn V. Holmes
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Onder Alpdogan
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Marcel R.M. van den Brink
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => George F. Murphy
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Olaf Penack
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Fernando Macian
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chen Liu
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Amanda M. Holland
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nicole Beauchemin
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Uttam K. Rao
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Marsinay Smith
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Renée Atallah
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => David Suh
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jimmy A. Rotolo
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Johanne L. Bautista
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sydney X. Lu
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Claire Turbide
)
)
)
[17] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lucy W. Kappel
)
)
)
[18] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vanessa M. Hubbard
)
)
)
[19] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Anne Marie Charbonneau-Allard
)
)
)
[20] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nury L. Yim
)
)
)
[21] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Christopher R. King
)
)
)
[22] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Robert R. Jenq
)
)
)
[23] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Il-Kang Na
)
)
)
[24] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Richard S. Blumberg
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 06
[M] => 07
[Type] => published
[Y] => 2011
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 19326203
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 6
)
[1] => Array
(
[Type] => issue
[Value] => 7
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => PLoS ONE
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |