Increased serum IL-33 levels may indicate vascular involvement in systemic sclerosis
| العنوان: | Increased serum IL-33 levels may indicate vascular involvement in systemic sclerosis |
|---|---|
| المؤلفون: | Thilo Gambichler, Alexander Kreuter, Elisabeth Opitz, Stefan Höxtermann, Sarah Terras, Rose K. C. Moritz |
| المصدر: | Annals of the rheumatic diseases. 72(1) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Immunology, Enzyme-Linked Immunosorbent Assay, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Smooth muscle, Gene expression, Immunology and Allergy, Medicine, Humans, In patient, Vascular Diseases, Orphan receptor, Scleroderma, Systemic, business.industry, Interleukins, Early disease, Middle Aged, Interleukin-33, Interleukin 33, Healthy individuals, Digestive tract, Female, business, Biomarkers |
| الوصف: | Interleukin 33 (IL-33) belongs to the IL-1 family and was found in smooth muscle cells, epithelial cells, fibroblasts, keratinocytes, endothelial cells, dendritic cells and activated macrophages.1 IL-33 binds the orphan receptor ST2 and induces gene expression of Th2-associated cytokines. Treatment of wild-type mice with IL-33 led to changes in vessels, digestive tract and lungs.2 Manetti et al 3 recently investigated serum IL-33 levels by means of an ELISA in 58 patients with systemic sclerosis (SSc) and 30 healthy individuals. They observed that serum IL-33 was significantly increased in patients with SSc as compared with healthy controls. They also found that serum IL-33 levels were associated with early disease stage and microvascular involvement as determined by capillaroscopy. The study of Manetti et al 3 prompted us to investigate serum IL-33 … |
| تدمد: | 1468-2060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc39d51acc4166c2734f23f42bc26752Test https://pubmed.ncbi.nlm.nih.gov/22858587Test |
| رقم الانضمام: | edsair.doi.dedup.....bc39d51acc4166c2734f23f42bc26752 |
| قاعدة البيانات: | OpenAIRE |
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