Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera
| العنوان: | Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera |
|---|---|
| المؤلفون: | Yuanpeng Li, Chengguo Xing, Balasubramanian Srinivasan, Marie A. Hugger, Ying Jing, Jian-Ping Wang, Xiaofeng Yao |
| المصدر: | Journal of the American Chemical Society. 132(12) |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Medical device, Chromatography, Time Factors, Chemistry, Interleukin-6, Iron, Early detection, Metal Nanoparticles, Nanotechnology, Enzyme-Linked Immunosorbent Assay, General Chemistry, Biosensing Techniques, Cobalt, Magnetoresistive sensor, Biochemistry, Catalysis, Biomarker (cell), Magnetics, Colloid and Surface Chemistry, Chronic disease, Biomarkers, Tumor, Disease biomarker, Humans, Biomarkers |
| الوصف: | A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates specific, accurate, and quick detection and quantification of interleukin-6, a low-abundance protein and a potential cancer biomarker, directly in 4 muL of unprocessed human sera. This platform is expected to facilitate the identification and validation of disease biomarkers. It may eventually lead to a low-cost personal medical device for chronic disease early detection, diagnosis, and prognosis. |
| تدمد: | 1520-5126 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb704949919962a05643be187b264bb2Test https://pubmed.ncbi.nlm.nih.gov/20192199Test |
| رقم الانضمام: | edsair.doi.dedup.....bb704949919962a05643be187b264bb2 |
| قاعدة البيانات: | OpenAIRE |
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