Psoriasis associated with idiopathic CD4+ T-cell lymphopenia: a regulatory T-cell defect?
| العنوان: | Psoriasis associated with idiopathic CD4+ T-cell lymphopenia: a regulatory T-cell defect? |
|---|---|
| المؤلفون: | Manuelle Viguier, Hervé Bachelez, G. Gener, Edouard Begon, Maxime Battistella, Nathalie Beneton, B. Baroudjian, C. Pagès |
| المصدر: | The British journal of dermatology. 171(1) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, business.industry, Regulatory T cell, FOXP3, CD4+ T-cell lymphopenia, Dermatology, Disease, medicine.disease, T-Lymphocytes, Regulatory, Immunodeficiency Syndrome, Immune system, medicine.anatomical_structure, Psoriasis, Immunology, Chronic Disease, medicine, Humans, Lymphocytopenia, business, T-Lymphocytopenia, Idiopathic CD4-Positive |
| الوصف: | Summary Idiopathic CD4+ lymphocytopenia (ICL) is a rare immunodeficiency syndrome of unknown origin for which the increased risks of opportunistic infections and of malignancies have been well established; however, skin dysimmune diseases, including psoriasis, have been scarcely reported up to now. We report herein the severe course of psoriasis in four patients with ICL, and show evidence for a defect in the skin recruitment of regulatory CD4+FoxP3+ T cells. These data raise the apparent paradigm of the occurrence of a severe immunomediated disease together with a profound T-cell defect, a model that might also apply to other immune deficiencies associated with psoriasis. |
| تدمد: | 1365-2133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba80ba57623e65117c9cc0bc0e8c171dTest https://pubmed.ncbi.nlm.nih.gov/24579866Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ba80ba57623e65117c9cc0bc0e8c171d |
| قاعدة البيانات: | OpenAIRE |
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