Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1
العنوان: | Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1 |
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المؤلفون: | Nissim Hay, Nava Segev |
المصدر: | Molecular Cell. 46:4-6 |
بيانات النشر: | Elsevier BV, 2012. |
سنة النشر: | 2012 |
مصطلحات موضوعية: | chemistry.chemical_classification, Saccharomyces cerevisiae Proteins, Leucyl-tRNA synthetase, Cell, Saccharomyces cerevisiae, Cell Biology, Biology, Article, Amino acid, medicine.anatomical_structure, chemistry, Biochemistry, Leucine, medicine, Leucine-tRNA Ligase, Molecular Biology, Signal Transduction, Transcription Factors |
الوصف: | The target of rapamycin complex 1 (TORC1) is an essential regulator of eukaryotic cell growth that responds to growth factors, energy levels, and amino acids. The mechanisms through which the preeminent amino acid leucine signals to the TORC1-regulatory Rag GTPases, which activate TORC1 within the yeast EGO complex (EGOC) or the structurally related mammalian Rag-Ragulator complex, remain elusive. We find that the leucyl-tRNA synthetase (LeuRS) Cdc60 interacts with the Rag GTPase Gtr1 of the EGOC in a leucine-dependent manner. This interaction is necessary and sufficient to mediate leucine signaling to TORC1 and is disrupted by the engagement of Cdc60 in editing mischarged tRNA(Leu). Thus, the EGOC-TORC1 signaling module samples, via the LeuRS-intrinsic editing domain, the fidelity of tRNA(Leu) aminoacylation as a proxy for leucine availability. |
تدمد: | 1097-2765 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cba3a70147ddf7cde9fb269242bd1bTest https://doi.org/10.1016/j.molcel.2012.03.028Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....b4cba3a70147ddf7cde9fb269242bd1b |
قاعدة البيانات: | OpenAIRE |
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