Impact of Pancreatic Autoantibodies in Pancreas Graft Survival After Pancreas-Kidney Transplantation
| العنوان: | Impact of Pancreatic Autoantibodies in Pancreas Graft Survival After Pancreas-Kidney Transplantation |
|---|---|
| المؤلفون: | Manuela Guedes de Almeida, Filipa V.M. Silva, La Salete Martins, Leonídio Dias, António Castro Henriques, Sofia Pedroso, Jorge Malheiro, Catarina Ribeiro, Nicole Pestana, Andreia Silva |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Graft Rejection, Male, medicine.medical_specialty, medicine.medical_treatment, Pancreas transplantation, Autoantigens, Gastroenterology, Pancreatic Autoantibodies, Interquartile range, Diabetes mellitus, Internal medicine, Humans, Medicine, Kidney transplantation, Autoantibodies, pancreas-kidney transplantation, Transplantation, Portugal, biology, Glutamate Decarboxylase, business.industry, Graft Survival, Autoantibody, Middle Aged, Madeira Island, medicine.disease, Kidney Transplantation, autoantibodies in Pancreas, PG survival, Diabetes Mellitus, Type 1, medicine.anatomical_structure, biology.protein, Female, Surgery, Pancreas Transplantation, Antibody, business, Pancreas |
| الوصف: | In simultaneous pancreas-kidney transplantation (SPKT), persistence or recurrence of pancreatic autoantibodies (PAs) has been associated with pancreas graft (PG) autoimmune-driven injury. Our aim was to analyze the impact of PAs on PG survival.Methods. Between January 1, 2000, and December 31, 2017, we studied 139 patients with post-SPKT antieglutamic acid decarboxylase (GAD) autoantibody. Alloimmune (ALI) events were defined as PG rejection and/or de novo donor-specific antibodies (DSA).Hence, 3 groups were defined: patients without ALI events or anti-GAD (n ¼ 42), those with ALI events (n ¼ 14), or those only with autoimmune events (positive for anti-GAD and no ALI events; n ¼ 83). Results. Male sex was predominant (n ¼ 72, 52%). Median age was 35 years (interquartile range: 31-39) and median follow-up was 6-7 years (interquartile range: 4.1-9.2). Regarding anti-GAD positivity post-SPKT (n ¼ 90, 65%), no differences were observed concerning age, sex, anti-HLA antibodies, HLA mismatch number and de novo DSA. ALI events were present in 10% (n ¼ 14). PG survival 15 years post-SPKT was better in patients without immune events (96%) followed by those with ALI (69%) and autoimmune events (63%) (P ¼ .025). Anti-GAD was associated to higher annualized mean Hb1AC (P ¼ .006) and lower mean C-peptide (P ¼ .013). According to pre- and post-SPKT anti-GAD status, conversion from negative to positive was associated to worse (63%) 10-year PG survival (P ¼ .044), compared to persistence of negative (100%) or positive anti-GAD (88%). Anti-islet cell and anti-insulin autoantibodies had no impact. Conclusion. Anti-GAD presence post-SPKT was associated to higher pâncreas disfunction and lower PG survival. De novo anti-GAD seems to offer a particular risk of PG failure. info:eu-repo/semantics/publishedVersion |
| تدمد: | 0041-1345 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b311b516da9502f569e9412e17aef3aeTest https://doi.org/10.1016/j.transproceed.2020.02.035Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b311b516da9502f569e9412e17aef3ae |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....b311b516da9502f569e9412e17aef3ae 870 3 unknown 869.682861328125 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....b311b516da9502f569e9412e17aef3ae&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Impact of Pancreatic Autoantibodies in Pancreas Graft Survival After Pancreas-Kidney Transplantation
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Manuela+Guedes+de+Almeida%22">Manuela Guedes de Almeida</searchLink><br /><searchLink fieldCode="AR" term="%22Filipa+V%2EM%2E+Silva%22">Filipa V.M. Silva</searchLink><br /><searchLink fieldCode="AR" term="%22La+Salete+Martins%22">La Salete Martins</searchLink><br /><searchLink fieldCode="AR" term="%22Leonídio+Dias%22">Leonídio Dias</searchLink><br /><searchLink fieldCode="AR" term="%22António+Castro+Henriques%22">António Castro Henriques</searchLink><br /><searchLink fieldCode="AR" term="%22Sofia+Pedroso%22">Sofia Pedroso</searchLink><br /><searchLink fieldCode="AR" term="%22Jorge+Malheiro%22">Jorge Malheiro</searchLink><br /><searchLink fieldCode="AR" term="%22Catarina+Ribeiro%22">Catarina Ribeiro</searchLink><br /><searchLink fieldCode="AR" term="%22Nicole+Pestana%22">Nicole Pestana</searchLink><br /><searchLink fieldCode="AR" term="%22Andreia+Silva%22">Andreia Silva</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Repositório Científico de Acesso Aberto de Portugal<br />Repositório Científico de Acesso Aberto de Portugal (RCAAP)<br />instacron:RCAAP ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier BV, 2020. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2020 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+Rejection%22">Graft Rejection</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Emedical%5Fspecialty%22">medicine.medical_specialty</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Emedical%5Ftreatment%22">medicine.medical_treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreas+transplantation%22">Pancreas transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Autoantigens%22">Autoantigens</searchLink><br /><searchLink fieldCode="DE" term="%22Gastroenterology%22">Gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+Autoantibodies%22">Pancreatic Autoantibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Interquartile+range%22">Interquartile range</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+mellitus%22">Diabetes mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22Internal+medicine%22">Internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+transplantation%22">Kidney transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Autoantibodies%22">Autoantibodies</searchLink><br /><searchLink fieldCode="DE" term="%22pancreas-kidney+transplantation%22">pancreas-kidney transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Transplantation%22">Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Portugal%22">Portugal</searchLink><br /><searchLink fieldCode="DE" term="%22biology%22">biology</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+Decarboxylase%22">Glutamate Decarboxylase</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Graft+Survival%22">Graft Survival</searchLink><br /><searchLink fieldCode="DE" term="%22Autoantibody%22">Autoantibody</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Madeira+Island%22">Madeira Island</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+Transplantation%22">Kidney Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22autoantibodies+in+Pancreas%22">autoantibodies in Pancreas</searchLink><br /><searchLink fieldCode="DE" term="%22PG+survival%22">PG survival</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+Mellitus%2C+Type+1%22">Diabetes Mellitus, Type 1</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22biology%2Eprotein%22">biology.protein</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreas+Transplantation%22">Pancreas Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Antibody%22">Antibody</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreas%22">Pancreas</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => In simultaneous pancreas-kidney transplantation (SPKT), persistence or recurrence of pancreatic autoantibodies (PAs) has been associated with pancreas graft (PG) autoimmune-driven injury. Our aim was to analyze the impact of PAs on PG survival.Methods. Between January 1, 2000, and December 31, 2017, we studied 139 patients with post-SPKT antieglutamic acid decarboxylase (GAD) autoantibody. Alloimmune (ALI) events were defined as PG rejection and/or de novo donor-specific antibodies (DSA).Hence, 3 groups were defined: patients without ALI events or anti-GAD (n ¼ 42), those with ALI events (n ¼ 14), or those only with autoimmune events (positive for anti-GAD and no ALI events; n ¼ 83). Results. Male sex was predominant (n ¼ 72, 52%). Median age was 35 years (interquartile range: 31-39) and median follow-up was 6-7 years (interquartile range: 4.1-9.2). Regarding anti-GAD positivity post-SPKT (n ¼ 90, 65%), no differences were observed concerning age, sex, anti-HLA antibodies, HLA mismatch number and de novo DSA. ALI events were present in 10% (n ¼ 14). PG survival 15 years post-SPKT was better in patients without immune events (96%) followed by those with ALI (69%) and autoimmune events (63%) (P ¼ .025). Anti-GAD was associated to higher annualized mean Hb1AC (P ¼ .006) and lower mean C-peptide (P ¼ .013). According to pre- and post-SPKT anti-GAD status, conversion from negative to positive was associated to worse (63%) 10-year PG survival (P ¼ .044), compared to persistence of negative (100%) or positive anti-GAD (88%). Anti-islet cell and anti-insulin autoantibodies had no impact. Conclusion. Anti-GAD presence post-SPKT was associated to higher pâncreas disfunction and lower PG survival. De novo anti-GAD seems to offer a particular risk of PG failure. info:eu-repo/semantics/publishedVersion ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0041-1345 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b311b516da9502f569e9412e17aef3ae" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b311b516da9502f569e9412e17aef3ae</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1016/j.transproceed.2020.02.035" linkWindow="_blank">https://doi.org/10.1016/j.transproceed.2020.02.035</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....b311b516da9502f569e9412e17aef3ae ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 1370
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Adult
[Type] => general
)
[1] => Array
(
[SubjectFull] => Graft Rejection
[Type] => general
)
[2] => Array
(
[SubjectFull] => Male
[Type] => general
)
[3] => Array
(
[SubjectFull] => medicine.medical_specialty
[Type] => general
)
[4] => Array
(
[SubjectFull] => medicine.medical_treatment
[Type] => general
)
[5] => Array
(
[SubjectFull] => Pancreas transplantation
[Type] => general
)
[6] => Array
(
[SubjectFull] => Autoantigens
[Type] => general
)
[7] => Array
(
[SubjectFull] => Gastroenterology
[Type] => general
)
[8] => Array
(
[SubjectFull] => Pancreatic Autoantibodies
[Type] => general
)
[9] => Array
(
[SubjectFull] => Interquartile range
[Type] => general
)
[10] => Array
(
[SubjectFull] => Diabetes mellitus
[Type] => general
)
[11] => Array
(
[SubjectFull] => Internal medicine
[Type] => general
)
[12] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[13] => Array
(
[SubjectFull] => Medicine
[Type] => general
)
[14] => Array
(
[SubjectFull] => Kidney transplantation
[Type] => general
)
[15] => Array
(
[SubjectFull] => Autoantibodies
[Type] => general
)
[16] => Array
(
[SubjectFull] => pancreas-kidney transplantation
[Type] => general
)
[17] => Array
(
[SubjectFull] => Transplantation
[Type] => general
)
[18] => Array
(
[SubjectFull] => Portugal
[Type] => general
)
[19] => Array
(
[SubjectFull] => biology
[Type] => general
)
[20] => Array
(
[SubjectFull] => Glutamate Decarboxylase
[Type] => general
)
[21] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[22] => Array
(
[SubjectFull] => Graft Survival
[Type] => general
)
[23] => Array
(
[SubjectFull] => Autoantibody
[Type] => general
)
[24] => Array
(
[SubjectFull] => Middle Aged
[Type] => general
)
[25] => Array
(
[SubjectFull] => Madeira Island
[Type] => general
)
[26] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[27] => Array
(
[SubjectFull] => Kidney Transplantation
[Type] => general
)
[28] => Array
(
[SubjectFull] => autoantibodies in Pancreas
[Type] => general
)
[29] => Array
(
[SubjectFull] => PG survival
[Type] => general
)
[30] => Array
(
[SubjectFull] => Diabetes Mellitus, Type 1
[Type] => general
)
[31] => Array
(
[SubjectFull] => medicine.anatomical_structure
[Type] => general
)
[32] => Array
(
[SubjectFull] => biology.protein
[Type] => general
)
[33] => Array
(
[SubjectFull] => Female
[Type] => general
)
[34] => Array
(
[SubjectFull] => Surgery
[Type] => general
)
[35] => Array
(
[SubjectFull] => Pancreas Transplantation
[Type] => general
)
[36] => Array
(
[SubjectFull] => Antibody
[Type] => general
)
[37] => Array
(
[SubjectFull] => business
[Type] => general
)
[38] => Array
(
[SubjectFull] => Pancreas
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Impact of Pancreatic Autoantibodies in Pancreas Graft Survival After Pancreas-Kidney Transplantation
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Manuela Guedes de Almeida
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Filipa V.M. Silva
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => La Salete Martins
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Leonídio Dias
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => António Castro Henriques
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sofia Pedroso
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jorge Malheiro
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Catarina Ribeiro
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nicole Pestana
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Andreia Silva
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 06
[Type] => published
[Y] => 2020
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00411345
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 52
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Transplantation Proceedings
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |