The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes
العنوان: | The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes |
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المؤلفون: | Antonio Ceriello, Valeria De Nigris, Roberto Testa, Lucia La Sala, Gemma Pujadas, Stefano Genovese, Anna Rita Bonfigli, Annachiara Uccellatore |
المصدر: | Diabetes Research and Clinical Practice. 114:64-68 |
بيانات النشر: | Elsevier BV, 2016. |
سنة النشر: | 2016 |
مصطلحات موضوعية: | Adult, Blood Glucose, Male, endocrine system, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Prostaglandin, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Dinoprost, medicine.disease_cause, 8 iso pgf2α, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Infusions, Parenteral, Vascular Diseases, Endothelial dysfunction, Glucagon-like peptide 1 receptor, Type 1 diabetes, business.industry, digestive, oral, and skin physiology, nutritional and metabolic diseases, General Medicine, medicine.disease, Glucagon-like peptide-1, Oxidative Stress, Diabetes Mellitus, Type 1, chemistry, Case-Control Studies, Hyperglycemia, Female, Endothelium, Vascular, business, hormones, hormone substitutes, and hormone antagonists, Oxidative stress |
الوصف: | Background To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function. |
تدمد: | 0168-8227 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dea89262a7f6329a402b6e0449c6e7Test https://doi.org/10.1016/j.diabres.2016.01.019Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....b2dea89262a7f6329a402b6e0449c6e7 |
قاعدة البيانات: | OpenAIRE |
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