A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease
| العنوان: | A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease |
|---|---|
| المؤلفون: | Frank R den Hartog, Mieke D. Trip, Huub J.A.M Penn, John J.P. Kastelein, Marjel van Dam, Rudolf J.A Buirma, Hans A Kragten |
| المساهمون: | Other departments |
| المصدر: | Clinical therapeutics, 23(3), 467-478. Excerpta Medica |
| بيانات النشر: | Elsevier BV, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, Simvastatin, medicine.medical_specialty, Indoles, Hypercholesterolemia, Drug Administration Schedule, law.invention, Fatty Acids, Monounsaturated, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, Fluvastatin, Prospective cohort study, Adverse effect, National Cholesterol Education Program, Aged, Pharmacology, biology, business.industry, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Endocrinology, Tolerability, HMG-CoA reductase, biology.protein, Female, lipids (amino acids, peptides, and proteins), business, medicine.drug |
| الوصف: | BACKGROUND: Use of cholesterol-lowering regimens has been shown to reduce the risk of coronary heart disease (CHD), both in primary and secondary prevention. However, there have been few studies of the relative benefits and risks of the various cholesterol-lowering agents in patient groups with specific risk factors for CHD. OBJECTIVE: The primary goal of this study was to compare the proportions of adult patients with primary hypercholesterolemia and a moderate to high risk for CHD achieving National Cholesterol Education Program low-density lipoprotein cholesterol (LDL-C) goals with titrate-to-goal regimens of simvastatin and fluvastatin. METHODS: This was a multicenter, prospective, randomized, double-blind, parallel-group study enrolling adult patients with type IIa or IIb primary hypercholesterolemia, LDL-C levels |
| تدمد: | 0149-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6083f049a13de59cfb351bc7af56413Test https://doi.org/10.1016/s0149-2918Test(01)80050-3 |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....a6083f049a13de59cfb351bc7af56413 |
| قاعدة البيانات: | OpenAIRE |
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