Connexins evolved after early chordates lost innexin diversity
العنوان: | Connexins evolved after early chordates lost innexin diversity |
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المؤلفون: | Georg Welzel, Stefan Schuster |
المصدر: | eLife eLife, Vol 11 (2022) |
بيانات النشر: | eLife Sciences Publications, Ltd, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | connexin, Glycosylation, Protein family, QH301-705.5, Science, Short Report, Chordate, gap junction evolution, Innexin, N-glycosylation, Biology, General Biochemistry, Genetics and Molecular Biology, Connexins, Evolution, Molecular, chemistry.chemical_compound, None, Animals, Biology (General), Chordata, Evolutionary Biology, General Immunology and Microbiology, Gap junction protein, General Neuroscience, Gap junction, Gap Junctions, General Medicine, innexin, biology.organism_classification, carbohydrates (lipids), chemistry, Evolutionary biology, pannexin, Medicine, lipids (amino acids, peptides, and proteins), Function (biology), Neuroscience |
الوصف: | Gap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins. Chordates retained innexin-homologs, but N-glycosylation prevents them from forming gap junctions. It is puzzling why chordates seem to exclusively use the new gap junction protein and why no chordates should exist that use non-glycosylated innexins to form gap junctions. Here, we identified glycosylation sites of 2270 innexins from 152 non-chordate and 274 chordate species. Among all chordates, we found not a single innexin without glycosylation sites. Surprisingly, the glycosylation motif is also widespread among non-chordate innexins indicating that glycosylated innexins are not a novelty of chordates. In addition, we discovered a loss of innexin diversity during the early chordate evolution. Most importantly, the most basal living chordates, which lack connexins, exclusively possess innexins with glycosylation sites. A bottleneck effect might thus explain why connexins have become the only protein used to form chordate gap junctions. |
اللغة: | English |
DOI: | 10.15495/epub_ubt_00006882 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4be0998d4d17de7dec8199e5495c2Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....a4f4be0998d4d17de7dec8199e5495c2 |
قاعدة البيانات: | OpenAIRE |