Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China
| العنوان: | Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China |
|---|---|
| المؤلفون: | Ying Huang, Jiabin Chen, Xiaowen Jiang, Yaling Shi, Jide Huang, Yingyi Huang, Xing Chen |
| المصدر: | Human Immunology |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, G-CSF, Granulocyte colony-stimulating factor, Severity of Illness Index, T-Lymphocytes, Regulatory, Gastroenterology, MCP-1, Monocyte chemoattractant protein-1, 0302 clinical medicine, Immunology and Allergy, IL, Interleukin, IL-2 receptor, B-Lymphocytes, COVID-19, Coronavirus disease 2019, biology, Th1, T helper 1, Immune cells, EDTA, Ethylenediaminetetraacetic acid, General Medicine, Middle Aged, Prognosis, PBS, Phosphate-buffered saline, WBC, White blood cells, Interleukin-10, Up-Regulation, IFN, Interferon, Th2, T helper 2, Killer Cells, Natural, Interleukin 10, Cytokines, Female, medicine.symptom, Research Article, Adult, China, medicine.medical_specialty, MIP-1A, Macrophage inflammatory protein 1 alpha, Immunology, NKT cells, Natural killer T cells, Inflammation, Tregs, Regulatory T cells, macromolecular substances, 03 medical and health sciences, Immune system, Internal medicine, Severity of illness, medicine, Humans, Lymphocyte Count, Interleukin-7 receptor, Interleukin 6, Aged, Interleukin-6, SARS-CoV-2, business.industry, IP-10, Interferon gamma-induced protein 10, TNF, Tumor necrosis factor, COVID-19, NK cells, Natural killer cells, 030104 developmental biology, biology.protein, business, CD8, 030215 immunology |
| الوصف: | To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4+ T cells and CD8+ T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4+CD25+CD127low Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4+ T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation. |
| تدمد: | 0198-8859 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a70e9df0e9f88464b7539e60bc6d2cTest https://doi.org/10.1016/j.humimm.2020.08.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3a70e9df0e9f88464b7539e60bc6d2c |
| قاعدة البيانات: | OpenAIRE |
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