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Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly

التفاصيل البيبلوغرافية
العنوان: Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly
المؤلفون: Raziye Akcılar, Ceylan Ayada, Sebahat Turgut, Fulya Akin, Günfer Turgut
بيانات النشر: Kluwer Academic Publishers, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Male, systolic blood pressure, genetic association, genotype, Angiotensinogen, cholesterol blood level, Blood Pressure, insulin blood level, low density lipoprotein cholesterol, chemistry.chemical_compound, Gene Frequency, INDEL Mutation, high density lipoprotein cholesterol, insulin resistance, Genotype, genetic polymorphism, Receptor, clinical article, biology, adult, article, General Medicine, Middle Aged, growth hormone blood level, female, Female, triacylglycerol, Acromegaly/enzymology/*genetics/physiopathology, Adult, Angiotensinogen/*genetics, Blood Pressure/genetics, Case-Control Studies, Gene Frequency/genetics, Genetic Predisposition to Disease, Humans, INDEL Mutation/*genetics, Peptidyl-Dipeptidase A/*genetics, Polymorphism, Single Nucleotide/*genetics, Receptor, Angiotensin, Type 1/*genetics, Angiotensin converting enzyme, medicine.medical_specialty, insulin, hypertension, angiotensin 1 receptor, dipeptidyl carboxypeptidase, AT1-receptor, Peptidyl-Dipeptidase A, gene frequency, Polymorphism, Single Nucleotide, Receptor, Angiotensin, Type 1, protein denaturation, male, Internal medicine, Acromegaly, Genetics, medicine, controlled study, human, Polymorphism, Molecular Biology, Angiotensin II receptor type 1, Triglyceride, diastolic blood pressure, Angiotensin-converting enzyme, medicine.disease, triacylglycerol blood level, Angiotensin II, somatomedin C, body mass, Endocrinology, Blood pressure, glucose blood level, chemistry, biology.protein, homozygosity
الوصف: Acromegaly is associated with increased morbidity and mortality related to cardiovascular disease. Hypertension is one of the most common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association between the frequencies of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and the angiotensin II type 1 receptor (AT1-R) A/C1166 gene polymorphisms and some clinical parameters of acromegalic patients. Total of 33 acromegalic patients and 63 controls were enrolled to study. We determined the ACE I/D, AGT M235T and AT1-R A/C1166 gene polymorphisms. Serum insulin, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol, growth hormone and Insulin-like growth factor I (IGF-I) levels of subjects were analyzed. The frequencies of ACE and M235T AGT genotype were not significantly different between control and patients. The distribution of AT1R A/C1166 genotypes was significantly different between patients and control subjects (P = 0.016). None of the three ACE genotypes, DD, ID and II displayed significant difference in acromegalic patients. A significant difference in systolic blood pressure and the serum IGF-I levels among the three AGT genotype, MM, MT and TT genotypes was found in patient group. Individuals with MT genotypes had significantly higher serum IGF-I levels and systolic blood pressure than MM and TT genotype subjects, P < 0.05. In addition, serum triglyceride and HDL levels differed significantly between MM and MT genotypes, P < 0.05. However, systolic blood pressure of patients with CC genotypes was found to be significantly higher than AA genotypes individuals in acromegaly group, P < 0.05. It can be said that the angiotensinojen MT and AT1R CC1166 genotype carriers may have more risk than other genotypes in the development of hypertension in acromegaly. © 2010 Springer Science+Business Media B.V.
اللغة: English
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e76bb23295505227da5da7e4e11c32Test
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6129Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....a2e76bb23295505227da5da7e4e11c32
قاعدة البيانات: OpenAIRE
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Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Acromegaly is associated with increased morbidity and mortality related to cardiovascular disease. Hypertension is one of the most common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association between the frequencies of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and the angiotensin II type 1 receptor (AT1-R) A/C1166 gene polymorphisms and some clinical parameters of acromegalic patients. Total of 33 acromegalic patients and 63 controls were enrolled to study. We determined the ACE I/D, AGT M235T and AT1-R A/C1166 gene polymorphisms. Serum insulin, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol, growth hormone and Insulin-like growth factor I (IGF-I) levels of subjects were analyzed. The frequencies of ACE and M235T AGT genotype were not significantly different between control and patients. The distribution of AT1R A/C1166 genotypes was significantly different between patients and control subjects (P = 0.016). None of the three ACE genotypes, DD, ID and II displayed significant difference in acromegalic patients. A significant difference in systolic blood pressure and the serum IGF-I levels among the three AGT genotype, MM, MT and TT genotypes was found in patient group. Individuals with MT genotypes had significantly higher serum IGF-I levels and systolic blood pressure than MM and TT genotype subjects, P &lt; 0.05. In addition, serum triglyceride and HDL levels differed significantly between MM and MT genotypes, P &lt; 0.05. However, systolic blood pressure of patients with CC genotypes was found to be significantly higher than AA genotypes individuals in acromegaly group, P &lt; 0.05. It can be said that the angiotensinojen MT and AT1R CC1166 genotype carriers may have more risk than other genotypes in the development of hypertension in acromegaly. &#169; 2010 Springer Science+Business Media B.V. )
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[PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sebahat Turgut ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fulya Akin ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Günfer Turgut ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2011 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsair ) [1] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) ) ) ) ) )
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