Poly(ADP-ribose)polymerase inhibition decreases angiogenesis
| العنوان: | Poly(ADP-ribose)polymerase inhibition decreases angiogenesis |
|---|---|
| المؤلفون: | Sandor Batkai, Partha Mukhopadhyay, Lucas Liaudet, Pal Pacher, György Haskó, Mohanraj Rajesh, Grzegorz Godlewski |
| المصدر: | Biochemical and Biophysical Research Communications, vol. 350, no. 4, pp. 1056-62 |
| بيانات النشر: | Elsevier BV, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Angiogenesis, Cells, Poly ADP ribose polymerase, Basic fibroblast growth factor, Biophysics, Neovascularization, Physiologic, Poly(ADP-ribose) Polymerase Inhibitors, Biology, Biochemistry, Article, chemistry.chemical_compound, Cell Movement, Humans, Molecular Biology, Cells, Cultured, Cell Proliferation, Tube formation, Dose-Response Relationship, Drug, Cell growth, Endothelial Cells, Cell Movement/drug effects Cell Proliferation/drug effects Cells Cells, Cultured Dose-Response Relationship, Drug Endothelial Cells/drug effects/*physiology Humans Isoquinolines/*administration & dosage Neovascularization, Physiologic/drug effects/*physiology Poly(ADP-ribose) Polymerases/*antagonists & inhibitors Quinolines/administration & dosage, Cell Biology, Isoquinolines, Molecular biology, Vascular endothelial growth factor, chemistry, Apoptosis, Quinolines, Cancer research, Ex vivo |
| الوصف: | Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation. We have recently demonstrated that PARP inhibition with 3-aminobenzamide or PJ-34 reduced vascular endothelial growth factor (VEGF)-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro. Here, we show dose-dependent reduction of VEGF- and basic fibroblast growth factor (bFGF)-induced proliferation, migration, and tube formation of HUVECs in vitro by two potent PARP inhibitors 5-aminoisoquinolinone-hydrochloride (5-AIQ) and 1,5-isoquinolinediol (IQD). Moreover, PARP inhibitors prevented the sprouting of rat aortic ring explants in an ex vivo assay of angiogenesis. These results establish the novel concept that PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers, tumor metastases, and certain retinopathies. |
| وصف الملف: | application/pdf |
| تدمد: | 0006-291X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f97b1e0714b55668ce1af0f805345Test https://doi.org/10.1016/j.bbrc.2006.09.160Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a09f97b1e0714b55668ce1af0f805345 |
| قاعدة البيانات: | OpenAIRE |
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