Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat
| العنوان: | Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat |
|---|---|
| المؤلفون: | Richard C. Ursillo, Gary T. Shearman, Harbans Lal |
| المصدر: | The Journal of Clinical Pharmacology. 21:16-19 |
| بيانات النشر: | Wiley, 1981. |
| سنة النشر: | 1981 |
| مصطلحات موضوعية: | Diarrhea, Male, Narcotics, Pharmacology, Diphenoxylate, business.industry, Clonidine, Rats, Anesthesia, Naloxone, Lofexidine, medicine, Animals, Pharmacology (medical), Antidiarrheals, business, medicine.drug |
| الوصف: | Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose-dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre- and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine and lofexidine. These data suggest that clonidine and lofexidine may provide potent antidiarrheal activity of a nonnarcotic nature. |
| تدمد: | 0091-2700 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea2acfee08dfb2da05e245232aa81d5Test https://doi.org/10.1002/j.1552-4604.1981.tb01726.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9ea2acfee08dfb2da05e245232aa81d5 |
| قاعدة البيانات: | OpenAIRE |
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