Substrate-product relation of 1-hydroxylase activity in primary hyperparathyroidism
| العنوان: | Substrate-product relation of 1-hydroxylase activity in primary hyperparathyroidism |
|---|---|
| المؤلفون: | Luciano Cominacini, Vincenzo LoCascio, Silvano Adami, G. Galvanini, D. Tartarotti, Marcello Ferrari |
| المصدر: | The New England journal of medicine. 313(18) |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Parathyroid hormone, chemistry.chemical_element, Calcium, Phosphates, chemistry.chemical_compound, Calcitriol, Oral administration, Internal medicine, medicine, Vitamin D and neurology, Humans, primary hyperparathyroidism, 25-(OH)2D, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Hyperparathyroidism, business.industry, Hydroxycholecalciferols, Liter, General Medicine, 1-hydrolase activity, 1, Middle Aged, Phosphate, medicine.disease, Endocrinology, chemistry, Parathyroid Hormone, Steroid Hydroxylases, Female, business, Primary hyperparathyroidism |
| الوصف: | The synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25-(OH)2D), is thought to be relatively insensitive to the serum concentration of its precursor, 25-hydroxyvitamin D (25-OH-D). We compared the effect of oral administration of 25-OH-D3 (50 micrograms per day for one month) on serum concentrations of calcium, phosphate, parathyroid hormone, 25-OH-D, and 1,25-(OH)2D in five healthy adults and in six patients with primary hyperparathyroidism. In normal adults the mean (+/- S.D.) serum level of 25-OH-D rose from 18 +/- 9 to 136 +/- 47 ng per milliliter; no significant changes were observed in the other serum levels. In contrast, comparable increases in the levels of circulating 25-OH-D in patients with primary hyperparathyroidism caused a consistent slight rise in serum calcium and phosphate levels, a partial suppression of parathyroid hormone, and a sharp increase in the level of 1,25-(OH)2D. During this period a significant positive correlation was found between serum concentrations of 25-OH-D and 1,25-(OH)2D (P less than 0.001). These results provide evidence that in patients with primary hyperparathyroidism, levels of circulating 1,25-(OH)2D may be more dependent on the prevailing serum concentrations of 25-OH-D than they are in normal adults. |
| تدمد: | 0028-4793 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbf4e3552a0b86ee8575dc2bdb99404Test https://pubmed.ncbi.nlm.nih.gov/3840228Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9bbf4e3552a0b86ee8575dc2bdb99404 |
| قاعدة البيانات: | OpenAIRE |
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