Multiple Vertebral Osteonecroses (Kümmell's Disease) After 10 Years on Denosumab: Is Osteocyte Apoptosis to Blame?
| العنوان: | Multiple Vertebral Osteonecroses (Kümmell's Disease) After 10 Years on Denosumab: Is Osteocyte Apoptosis to Blame? |
|---|---|
| المؤلفون: | Benoit Le Goff, Marguerite Chemel-Mary, Yves Maugars, Géraldine Bart, Pascale Guillot, Christelle Darrieutort-Laffite, Mélanie Gahier-Penhoat, Joëlle Glémarec |
| المصدر: | Calcified tissue international. 102(3) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteoporosis, 030209 endocrinology & metabolism, Apoptosis, Osteocytes, Bone resorption, Bone and Bones, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Osteoprotegerin, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Aged, 80 and over, business.industry, Wnt signaling pathway, Osteonecrosis, medicine.disease, Spine, 030104 developmental biology, medicine.anatomical_structure, Denosumab, DKK1, Osteocyte, Spinal Fractures, Female, Bone Remodeling, business, medicine.drug |
| الوصف: | We report here a case of multiple vertebral osteonecroses with intrasomatic gaseous dissection (Kummell’s disease) occurring 1 year after the end of a 10-year course of denosumab treatment for osteoporosis without fractures. Histomorphometry and bone remodeling markers revealed major bone resorption and the persistence of an inhibition of bone formation. The presence of multiple empty lacunae in the bone provided evidence for high levels of osteocyte apoptosis. Osteocytes direct bone resorption (via the RANK/RANK-L/osteoprotegerin system) and formation (Wnt system, with SOST and DKK1) pathways. The vertebral osteonecrosis in our case may, therefore, have resulted from osteocyte apoptosis, decompensated by the sudden reactivation of bone remodeling after the cessation of denosumab treatment. |
| تدمد: | 1432-0827 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9673c3683a34f11f24d01e7c3d0136f0Test https://pubmed.ncbi.nlm.nih.gov/29318330Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9673c3683a34f11f24d01e7c3d0136f0 |
| قاعدة البيانات: | OpenAIRE |
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