Sustained Impact of Real-time Continuous Glucose Monitoring in Adults With Type 1 Diabetes on Insulin Pump Therapy: Results After the 24-Month RESCUE Study

التفاصيل البيبلوغرافية
العنوان: Sustained Impact of Real-time Continuous Glucose Monitoring in Adults With Type 1 Diabetes on Insulin Pump Therapy: Results After the 24-Month RESCUE Study
المؤلفون: RESCUE trial investigators, Charleer, Sara, De Block, Christophe, Nobels, Frank, Radermecker, Regis P, Lowyck, Ine, Mullens, Annelies, Scarnière, Denis, Spincemaille, Katrien, Strivay, Marie, Weber, Eric, Taes, Youri, Vercammen, Chris, Keymeulen, Bart, Mathieu, Chantal, Gillard, Pieter
المساهمون: Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Diabetes Clinic, RESCUE Trial Investigators
المصدر: Diabetes care
سنة النشر: 2020
مصطلحات موضوعية: Blood Glucose, Male, Time Factors, endocrine system diseases, type 1 diabetes, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, Insulin, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Fear, Middle Aged, Female, Cohort study, Insulin pump, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Hypoglycemia, 03 medical and health sciences, Young Adult, Insulin Infusion Systems, Diabetes mellitus, Insulin Pump Therapy, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Glycemic, Advanced and Specialized Nursing, Glycated Hemoglobin, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, nutritional and metabolic diseases, medicine.disease, Diabetes Mellitus, Type 1, 24-Month RESCUE Study, Hyperglycemia, Emergency medicine, Real-Time Continuous Glucose Monitoring, Quality of Life, Human medicine, business
الوصف: OBJECTIVEIn recent years, a growing number of people with type 1 diabetes gained access to real-time continuous glucose monitoring (rtCGM). Long-term benefits of rtCGM are unclear because of a lack of large studies of long duration. We evaluated whether real-world rtCGM use up to 24 months offered benefits, particularly in those living with impaired awareness of hypoglycemia (IAH).RESEARCH DESIGN AND METHODSThis 24-month, prospective, observational cohort study followed 441 adults with insulin pumps receiving full reimbursement for rtCGM. Forty-two percent had IAH. The primary end point was evolution of HbA1c, with secondary end points change in acute hypoglycemia complications, diabetes-related work absenteeism, and quality of life scores. Additionally, we evaluated whether people could achieve glycemic consensus targets during follow-up.RESULTSAfter 24 months, HbA1c remained significantly lower compared with baseline (7.64% [60 mmol/mol] vs. 7.37% [57 mmol/mol], P < 0.0001). Sustained benefits were also observed for the score on the hypoglycemia fear survey and hypoglycemia-related acute complications irrespective of hypoglycemia awareness level. People with IAH had the strongest improvement, especially for severe hypoglycemia (862 events in the year before vs. 119 events per 100 patient-years in the 2nd year, P < 0.0001). Over 24 months, more people were able to meet hypoglycemia consensus targets at the expense of slightly fewer people achieving hyperglycemia consensus targets. Furthermore, the number of people with HbA1c CONCLUSIONSUse of rtCGM led to sustained improvements in hypoglycemia-related glucose control over 24 months. Lower fear of hypoglycemia, fewer acute hypoglycemia-related events, and fewer diabetes-related days off from work were observed, particularly in those with IAH.
تدمد: 1935-5548
0149-5992
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913eaa04d022f4d0800a7882e91e5ac3Test
https://pubmed.ncbi.nlm.nih.gov/33067260Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....913eaa04d022f4d0800a7882e91e5ac3
قاعدة البيانات: OpenAIRE
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