Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke
| العنوان: | Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke |
|---|---|
| المؤلفون: | Yun-Feng Guan, Sai-Long Zhang, Xia Wang, Pei Wang, Chao-Yu Miao, Tian-Ying Xu, Shu-Na Wang |
| المصدر: | CNS Neuroscience & Therapeutics. 22:782-788 |
| بيانات النشر: | Wiley, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Nicotinamide phosphoribosyltransferase, Nicotinamide adenine dinucleotide, Pharmacology, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, 0302 clinical medicine, P7C3, Tubulin, immune system diseases, hemic and lymphatic diseases, Pharmacology (medical), Cells, Cultured, Cerebral Cortex, Neurons, Cerebral infarction, Infarction, Middle Cerebral Artery, Cell Hypoxia, Psychiatry and Mental health, Neuroprotective Agents, Biochemistry, Brain Infarction, Cell Survival, Carbazoles, Ischemia, Neuroprotection, 03 medical and health sciences, Physiology (medical), Glial Fibrillary Acidic Protein, medicine, Animals, cardiovascular diseases, Viability assay, business.industry, Original Articles, NAD, medicine.disease, Rats, Mice, Inbred C57BL, Disease Models, Animal, Glucose, 030104 developmental biology, nervous system, chemistry, NAD+ kinase, business, 030217 neurology & neurosurgery |
| الوصف: | Summary Aim NAMPT is a novel therapeutic target of ischemic stroke. The aim of this study was to investigate the effect of a potential NAMPT activator, P7C3-A20, an aminopropyl carbazole derivative, on ischemic stroke. Methods In vitro study, neuron protection effect of P7C3-A20 was investigated by co-incubation with primary neurons subjected to oxygen–glucose deprivation (OGD) or oxygen–glucose deprivation/reperfusion (OGD/R) injury. In vivo experiment, P7C3-A20 was administrated in middle cerebral artery occlusion (MCAO) rats and infarct volume was examined. Lastly, the brain tissue nicotinamide adenine dinucleotide (NAD) levels were detected in P7C3-A20 treated normal or MCAO mice. Results Cell viability, morphology, and Tuj-1 staining confirmed the neuroprotective effect of P7C3-A20 in OGD or OGD/R model. P7C3-A20 administration significantly reduced cerebral infarction in MCAO rats. Moreover, brain NAD levels were elevated both in normal and MCAO mice after P7C3-A20 treatment. Conclusions P7C3-A20 has neuroprotective effect in cerebral ischemia. The study contributes to the development of NAMPT activators against ischemic stroke and expands the horizon of the neuroprotective effect of aminopropyl carbazole chemicals. |
| تدمد: | 1755-5930 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c831b389201a826a4d522847cd46039Test https://doi.org/10.1111/cns.12576Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c831b389201a826a4d522847cd46039 |
| قاعدة البيانات: | OpenAIRE |
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