Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the 'window' of implantation
العنوان: | Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the 'window' of implantation |
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المؤلفون: | Hyunjung Jade Lim, Sanjoy K. Das, J. Wang, Niranjan Das, G.D. Plowman, B. Schryver, Sudhansu K. Dey |
المصدر: | Developmental biology. 190(2) |
سنة النشر: | 1997 |
مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, medicine.drug_class, Uterus, Biology, Polymerase Chain Reaction, Epiregulin, Andrology, Mice, Stroma, Pregnancy, Internal medicine, medicine, Animals, implantation, Tissue Distribution, Blastocyst, Embryo Implantation, RNA, Messenger, Betacellulin, Growth Substances, Molecular Biology, reproductive and urinary physiology, mouse, In Situ Hybridization, Regulation of gene expression, Epidermal Growth Factor, urogenital system, Gene Expression Regulation, Developmental, Cell Biology, Blotting, Northern, Apposition, medicine.anatomical_structure, Endocrinology, Estrogen, embryonic structures, Intercellular Signaling Peptides and Proteins, Female, Developmental Biology |
الوصف: | In the mouse, the process of implantation is initiated by the attachment reaction between the blastocyst trophectoderm and uterine luminal epithelium that occurs at 2200–2300 h on day 4 (day 1 = vaginal plug) of pregnancy. Several members of the EGF family are considered important in embryo–uterine interactions during implantation. This investigation demonstrates that the expression of two additions to the family, betacellulin and epiregulin, are exquisitely restricted to the mouse uterine luminal epithelium and underlying stroma adjacent to the implanting blastocyst. These genes are not expressed during progesterone-maintained delayed implantation, but are rapidly switched on in the uterus surrounding the implanting blastocyst following termination of the delay by estrogen. These results provide evidence that expression of betacellulin and epiregulin in the uterus requires the presence of an active blastocyst and suggest an involvement of these growth factors in the process of implantation. |
تدمد: | 0012-1606 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8847b884e443cfc469bb179de868617dTest https://pubmed.ncbi.nlm.nih.gov/9344537Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....8847b884e443cfc469bb179de868617d |
قاعدة البيانات: | OpenAIRE |
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