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Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients

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العنوان:	Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients
المؤلفون:	Marta Pelczyńska, Teresa Grzelak, Paweł Bogdański, Aniceta Ada Mikulska, Krystyna Czyżewska
المصدر:	Biomolecules Volume 11 Issue 4 Biomolecules, Vol 11, Iss 517, p 517 (2021)
بيانات النشر:	Multidisciplinary Digital Publishing Institute, 2021.
سنة النشر:	2021
مصطلحات موضوعية:	Adult, 0301 basic medicine, total antioxidant status, animal structures, hypertension, Circadian clock, lcsh:QR1-502, CLOCK Proteins, Physiology, Blood Pressure, cryptochrome 1, 030204 cardiovascular system & hematology, Biochemistry, Article, lcsh:Microbiology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, circadian clock, Humans, Medicine, Circadian rhythm, Exercise, Life Style, Molecular Biology, circadian locomotor output cycles kaput, Aged, Metabolic Syndrome, Sleep quality, medicine.diagnostic_test, business.industry, Middle Aged, Anthropometry, Cryptochromes, Antioxidant capacity, 030104 developmental biology, Blood pressure, Case-Control Studies, Female, Sleep, business, Lipid profile, diet, Biomarkers, biological clocks
الوصف:	Background: Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins—cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, and quality of sleep) in hypertensive patients. Methods: In 31 females with hypertension (HT) and 55 non-hypertensive women (NHT) the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile, and glycemia were analyzed. Blood pressure and anthropometric measurements, nutritional, exercise, and sleep analyses were performed. Results: In the HT group, the CRY1 level was 37.38% lower than in the NHT group. No differences were noted in CLOCK concentration between groups. BMI, FBG, and TG were higher in the HT group compared to the NHT group, while TC, LDL, and HDL levels were similar. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity, or sleep quality, although CRY1 was associated with some anthropometric indicators. In the HT group, increased CLOCK and CRY1 values were associated with a high TAS level. Conclusions: The serum level of CRY1 could be considered in a detailed diagnostic of hypertension risk in populations with abnormal anthropometric indices.
وصف الملف:	application/pdf
اللغة:	English
تدمد:	2218-273X
DOI:	10.3390/biom11040517
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e4230490b2d69d26a78a245a105babTest
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....87e4230490b2d69d26a78a245a105bab
قاعدة البيانات:	OpenAIRE

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The aim of the study was to evaluate the concentration of selected clock proteins—cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, and quality of sleep) in hypertensive patients. Methods: In 31 females with hypertension (HT) and 55 non-hypertensive women (NHT) the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile, and glycemia were analyzed. Blood pressure and anthropometric measurements, nutritional, exercise, and sleep analyses were performed. Results: In the HT group, the CRY1 level was 37.38% lower than in the NHT group. No differences were noted in CLOCK concentration between groups. BMI, FBG, and TG were higher in the HT group compared to the NHT group, while TC, LDL, and HDL levels were similar. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity, or sleep quality, although CRY1 was associated with some anthropometric indicators. In the HT group, increased CLOCK and CRY1 values were associated with a high TAS level. 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