أعرض في EDS

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

التفاصيل البيبلوغرافية
العنوان:	Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction
المؤلفون:	Mariza de Andrade, Satoshi Yoshino, Julie M. Cunningham, Megha Prasad, Elizabeth J. Atkinson, Lilach O. Lerman, Amir Lerman, Tatsuo Aoki, Rebecca Cilluffo, Patricia J.M. Best
المصدر:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
بيانات النشر:	Ovid Technologies (Wolters Kluwer Health), 2016.
سنة النشر:	2016
مصطلحات موضوعية:	Male, 0301 basic medicine, medicine.medical_specialty, endothelium, Endothelium, Angiogenesis, Coronary Disease, Coronary Artery Disease, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Coronary artery disease, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Insulin resistance, Internal medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, Endothelial dysfunction, Genetic Association Studies, Original Research, Framingham Risk Score, business.industry, Middle Aged, medicine.disease, Coronary Vessels, PON1, acetylcholine, Functional Genomics, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Cardiology, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Artery
الوصف:	Background Endothelial dysfunction is an early stage of atherosclerosis. Single‐nucleotide polymorphisms ( SNP s) have been associated with vascular dysfunction, cardiac events, and coronary artery remodeling. We aimed to detect SNP s associated with endothelial dysfunction and determine whether these associations are sex specific. Methods and Results Six hundred forty‐three subjects without significant obstructive coronary artery disease underwent invasive coronary endothelial function assessment. We collected data from 1536 SNP s that had previously been associated with vasoreactivity, angiogenesis, inflammation, artery calcification, atherosclerotic risk factors, insulin resistance, hormone levels, blood coagulability, or with coronary heart disease. Coronary vascular reactivity was assessed by the percent change in coronary artery diameter ≤ −20% after an intracoronary bolus injection of acetylcholine on invasive coronary physiology study. SNP s significantly associated with coronary epicardial endothelial dysfunction were ADORA 1 , KCNQ 1 , and DNAJC 4 in the whole cohort, LPA , MYBPH , ADORA 3 , and PON 1 in women and KIF 6 and NFKB 1 in men ( P Conclusions We have identified several significant SNP s that are associated with an increased risk of coronary endothelial dysfunction. These associations appear to be sex specific and may explain gender‐related differences in development of atherosclerosis.
تدمد:	2047-9980
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878904d2ec6fec7ccbe8031794a0ff46Test https://doi.org/10.1161/jaha.115.002544Test
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....878904d2ec6fec7ccbe8031794a0ff46
قاعدة البيانات:	OpenAIRE

ResultId	1
Header	edsair OpenAIRE edsair.doi.dedup.....878904d2ec6fec7ccbe8031794a0ff46 797 3 unknown 796.81689453125
PLink	https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....878904d2ec6fec7ccbe8031794a0ff46&custid=s6537998&authtype=sso
FullText	Array ( [Availability] => 0 )
Items	Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction ) Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Mariza+de+Andrade%22">Mariza de Andrade</searchLink><br /><searchLink fieldCode="AR" term="%22Satoshi+Yoshino%22">Satoshi Yoshino</searchLink><br /><searchLink fieldCode="AR" term="%22Julie+M%2E+Cunningham%22">Julie M. Cunningham</searchLink><br /><searchLink fieldCode="AR" term="%22Megha+Prasad%22">Megha Prasad</searchLink><br /><searchLink fieldCode="AR" term="%22Elizabeth+J%2E+Atkinson%22">Elizabeth J. Atkinson</searchLink><br /><searchLink fieldCode="AR" term="%22Lilach+O%2E+Lerman%22">Lilach O. Lerman</searchLink><br /><searchLink fieldCode="AR" term="%22Amir+Lerman%22">Amir Lerman</searchLink><br /><searchLink fieldCode="AR" term="%22Tatsuo+Aoki%22">Tatsuo Aoki</searchLink><br /><searchLink fieldCode="AR" term="%22Rebecca+Cilluffo%22">Rebecca Cilluffo</searchLink><br /><searchLink fieldCode="AR" term="%22Patricia+J%2EM%2E+Best%22">Patricia J.M. Best</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Ovid Technologies (Wolters Kluwer Health), 2016. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2016 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Emedical%5Fspecialty%22">medicine.medical_specialty</searchLink><br /><searchLink fieldCode="DE" term="%22endothelium%22">endothelium</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium%22">Endothelium</searchLink><br /><searchLink fieldCode="DE" term="%22Angiogenesis%22">Angiogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+Disease%22">Coronary Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+Artery+Disease%22">Coronary Artery Disease</searchLink><br /><searchLink fieldCode="DE" term="%22030204+cardiovascular+system+%26+hematology%22">030204 cardiovascular system & hematology</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%2C+Single+Nucleotide%22">Polymorphism, Single Nucleotide</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+artery+disease%22">Coronary artery disease</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+Factors%22">Sex Factors</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+resistance%22">Insulin resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Internal+medicine%22">Internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+Predisposition+to+Disease%22">Genetic Predisposition to Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelial+dysfunction%22">Endothelial dysfunction</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+Association+Studies%22">Genetic Association Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Original+Research%22">Original Research</searchLink><br /><searchLink fieldCode="DE" term="%22Framingham+Risk+Score%22">Framingham Risk Score</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+Vessels%22">Coronary Vessels</searchLink><br /><searchLink fieldCode="DE" term="%22PON1%22">PON1</searchLink><br /><searchLink fieldCode="DE" term="%22acetylcholine%22">acetylcholine</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+Genomics%22">Functional Genomics</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22030104+developmental+biology%22">030104 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology%22">Cardiology</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium%2C+Vascular%22">Endothelium, Vascular</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology+and+Cardiovascular+Medicine%22">Cardiology and Cardiovascular Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22Artery%22">Artery</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background Endothelial dysfunction is an early stage of atherosclerosis. Single‐nucleotide polymorphisms ( SNP s) have been associated with vascular dysfunction, cardiac events, and coronary artery remodeling. We aimed to detect SNP s associated with endothelial dysfunction and determine whether these associations are sex specific. Methods and Results Six hundred forty‐three subjects without significant obstructive coronary artery disease underwent invasive coronary endothelial function assessment. We collected data from 1536 SNP s that had previously been associated with vasoreactivity, angiogenesis, inflammation, artery calcification, atherosclerotic risk factors, insulin resistance, hormone levels, blood coagulability, or with coronary heart disease. Coronary vascular reactivity was assessed by the percent change in coronary artery diameter ≤ −20% after an intracoronary bolus injection of acetylcholine on invasive coronary physiology study. SNP s significantly associated with coronary epicardial endothelial dysfunction were ADORA 1 , KCNQ 1 , and DNAJC 4 in the whole cohort, LPA , MYBPH , ADORA 3 , and PON 1 in women and KIF 6 and NFKB 1 in men ( P Conclusions We have identified several significant SNP s that are associated with an increased risk of coronary endothelial dysfunction. These associations appear to be sex specific and may explain gender‐related differences in development of atherosclerosis. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2047-9980 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878904d2ec6fec7ccbe8031794a0ff46" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878904d2ec6fec7ccbe8031794a0ff46</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1161/jaha.115.002544" linkWindow="_blank">https://doi.org/10.1161/jaha.115.002544</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....878904d2ec6fec7ccbe8031794a0ff46 )
RecordInfo	Array ( [BibEntity] => Array ( [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Male [Type] => general ) [1] => Array ( [SubjectFull] => 0301 basic medicine [Type] => general ) [2] => Array ( [SubjectFull] => medicine.medical_specialty [Type] => general ) [3] => Array ( [SubjectFull] => endothelium [Type] => general ) [4] => Array ( [SubjectFull] => Endothelium [Type] => general ) [5] => Array ( [SubjectFull] => Angiogenesis [Type] => general ) [6] => Array ( [SubjectFull] => Coronary Disease [Type] => general ) [7] => Array ( [SubjectFull] => Coronary Artery Disease [Type] => general ) [8] => Array ( [SubjectFull] => 030204 cardiovascular system & hematology [Type] => general ) [9] => Array ( [SubjectFull] => Polymorphism, Single Nucleotide [Type] => general ) [10] => Array ( [SubjectFull] => Coronary artery disease [Type] => general ) [11] => Array ( [SubjectFull] => 03 medical and health sciences [Type] => general ) [12] => Array ( [SubjectFull] => Sex Factors [Type] => general ) [13] => Array ( [SubjectFull] => 0302 clinical medicine [Type] => general ) [14] => Array ( [SubjectFull] => Insulin resistance [Type] => general ) [15] => Array ( [SubjectFull] => Internal medicine [Type] => general ) [16] => Array ( [SubjectFull] => Genetics [Type] => general ) [17] => Array ( [SubjectFull] => medicine [Type] => general ) [18] => Array ( [SubjectFull] => Humans [Type] => general ) [19] => Array ( [SubjectFull] => Genetic Predisposition to Disease [Type] => general ) [20] => Array ( [SubjectFull] => Endothelial dysfunction [Type] => general ) [21] => Array ( [SubjectFull] => Genetic Association Studies [Type] => general ) [22] => Array ( [SubjectFull] => Original Research [Type] => general ) [23] => Array ( [SubjectFull] => Framingham Risk Score [Type] => general ) [24] => Array ( [SubjectFull] => business.industry [Type] => general ) [25] => Array ( [SubjectFull] => Middle Aged [Type] => general ) [26] => Array ( [SubjectFull] => medicine.disease [Type] => general ) [27] => Array ( [SubjectFull] => Coronary Vessels [Type] => general ) [28] => Array ( [SubjectFull] => PON1 [Type] => general ) [29] => Array ( [SubjectFull] => acetylcholine [Type] => general ) [30] => Array ( [SubjectFull] => Functional Genomics [Type] => general ) [31] => Array ( [SubjectFull] => 3. Good health [Type] => general ) [32] => Array ( [SubjectFull] => 030104 developmental biology [Type] => general ) [33] => Array ( [SubjectFull] => medicine.anatomical_structure [Type] => general ) [34] => Array ( [SubjectFull] => Cardiology [Type] => general ) [35] => Array ( [SubjectFull] => Female [Type] => general ) [36] => Array ( [SubjectFull] => Endothelium, Vascular [Type] => general ) [37] => Array ( [SubjectFull] => Cardiology and Cardiovascular Medicine [Type] => general ) [38] => Array ( [SubjectFull] => business [Type] => general ) [39] => Array ( [SubjectFull] => Artery [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mariza de Andrade ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Satoshi Yoshino ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Julie M. Cunningham ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Megha Prasad ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Elizabeth J. Atkinson ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lilach O. Lerman ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Amir Lerman ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Tatsuo Aoki ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rebecca Cilluffo ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Patricia J.M. Best ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 03 [M] => 04 [Type] => published [Y] => 2016 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 20479980 ) [1] => Array ( [Type] => issn-locals [Value] => edsair ) [2] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 5 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Journal of the American Heart Association [Type] => main ) ) ) ) ) ) )
IllustrationInfo