A first update on mapping the human genetic architecture of COVID-19
| العنوان: | A first update on mapping the human genetic architecture of COVID-19 |
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| المؤلفون: | COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Batini, C, Tobin, MD, Venn, LD, Lee, PH, Shrine, N, Williams, AT, Guyatt, AL, John, C, Packer, RJ, Ali, A, Free, RC, Wang, X, Wain, LV, Hollox, EJ, Bee, CE, Adams, EL, Palotie, A, Ripatti, S, Ruotsalainen, S, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Kaunisto, M, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Bochud, PY, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, JY, Pantet, O, Gonseth Nussle, S, Bochud, M, D’Acremont, V, Estoppey Younes, S, Albrich, WC, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R., Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, de Cid, R, Carreras, A, Moreno, V, Kogevinas, M, Galván-Femenía, I, Blay, N, Farré, X, Sumoy, L, Cortés, B, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Renieri, A, Mari, F, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, PG, Panese, S, Scaggiante, R, Monica, MD, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Biagio, AD, Masucci, L, Valente, S, Mandalà, M, Zucchi, P, Giannattasio, F, Coviello, DA, Mussini, C, Tavecchia, L, Crotti, L, Rizzi, M, Rovere, MTL, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Pietro, MD, Sabrina, R, Luchi, S, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, MA, Rizzo, CL, Pinto, AM, Beligni, G, Tommasi, A, Sarno, LD, Palmieri, M, Carriero, ML, Alaverdian, D, Busani, S, Bruno, R, Vecchia, M, Belli, MA, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, MD, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Bergantini, L, D’Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazzi, A, Lorubbio, M, Miraglia, FG, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Paciosi, F, Andretta, F, Gatti, F, Parisi, SG, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, GM, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Bottà, G, Domenico, PD, Rancan, I, Bianchi, F, Colombo, R, Barbieri, C, Acquilini, D, Andreucci, E, Segala, FV, Tiseo, G, Falcone, M, Lista, M, Poscente, M, Vivo, OD, Petrocelli, P, Guarnaccia, A, Baroni, S, van Heel, DA, Hunt, KA, Trembath, RC, Huang, QQ, Martin, HC, Mason, D, Trivedi, B, Wright, J, Finer, S, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, CJ, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Griffiths, C, Hurles, M, Hussain, S, Islam, K, Khan, A, Lavery, C, Lee, SH, Lerner, R, MacArthur, D, MacLaughlin, B, Martin, H, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Griffiths, CJ, Smith, AV, Boughton, AP, Li, KW, LeFaive, J, Annis, A, Niavarani, A, Aliannejad, R, Sharififard, B, Amirsavadkouhi, A, Naderpour, Z, Tadi, HA, Aleagha, AE, Ahmadi, S, Moghaddam, SBM, Adamsara, A, Saeedi, M, Abdollahi, H, Hosseini, A, Chariyavilaskul, P, Jantarabenjakul, W, Hirankarn, N, Chamnanphon, M, Suttichet, TB, Shotelersuk, V, Pongpanich, M, Phokaew, C, Chetruengchai, W, Putchareon, O, Torvorapanit, P, Puthanakit, T, Suchartlikitwong, P, Nilaratanakul, V, Sodsai, P, Brumpton, BM, Hveem, K, Willer, C, Zhou, W, Rogne, T, Solligard, E, Åsvold, BO, Franke, L, Boezen, M, Deelen, P, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, JM, van Blokland, I, Lanting, P, Ori, APS, Feng, Y-CA, Mercader, J, Weiss, ST, Karlson, EW, Smoller, JW, Murphy, SN, Meigs, JB, Woolley, AE, Green, RC, Perez, EF, Zöllner, S, Wang, J, Beck, A, Sloofman, LG, Ascolillo, S, Sebra, RP, Collins, BL, Levy, T, Buxbaum, JD, Sealfon, SC, Jordan, DM, Thompson, RC, Gettler, K, Chaudhary, K, Belbin, GM, Preuss, M, Hoggart, C, Choi, S, Underwood, SJ, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, LL, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, AW, Beckmann, ND, Schadt, EE, Abul-Husn, NS, Cho, JH, Itan, Y, Kenny, EE, Loos, RJF, Nadkarni, GN, Do, R, O’Reilly, P, Huckins, LM, Ferreira, MAR, Abecasis, GR, Leader, JB, Cantor, MN, Justice, AE, Carey, DJ, Chittoor, G, Josyula, NS, Kosmicki, JA, Horowitz, JE, Baras, A, Gass, MC, Yadav, A, Mirshahi, T, Hottenga, JJ, Bartels, M, de geus, EEJC, Nivard, MMG, Verma, A, Ritchie, MD, Rader, D, Li, B, Verma, SS, Lucas, A, Bradford, Y, Abedalthagafi, M, Alaamery, M, Alshareef, A, Sawaji, M, Massadeh, S, AlMalik, A, Alqahtani, S, Baraka, D, Harthi, FA, Alsolm, E, Safieh, LA, Alowayn, AM, Alqubaishi, F, Mutairi, AA, Mangul, S, Almutairi, M, Aljawini, N, Albesher, N, Arabi, YM, Mahmoud, ES, Khattab, AK, Halawani, RT, Alahmadey, ZZ, Albakri, JK, Felemban, WA, Suliman, BA, Hasanato, R, Al-Awdah, L, Alghamdi, J, AlZahrani, D, AlJohani, S, Al-Afghani, H, AlDhawi, N, AlBardis, H, Alkwai, S, Alswailm, M, Almalki, F, Albeladi, M, Almohammed, I, Barhoush, E, Albader, A, Alotaibi, S, Alghamdi, B, Jung, J, fawzy, MS, Alrashed, M, Zeberg, H, Frithiof, R, Hultström, M, Lipcsey, M, Tardif, N, Rooyackers, O, Grip, J, Maricic, T, Helgeland, Ø, Magnus, P, Trogstad, L-IS, Lee, Y, Harris, JR, Mangino, M, Spector, TD, Emma, D, Moutsianas, L, Caulfield, MJ, Scott, RH, Kousathanas, A, Pasko, D, Walker, S, Stuckey, A, Odhams, CA, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, KJ, Martin, AR, Wilson, DJ, Spencer, CCA, Crook, DW, Wyllie, DH, O’Connell, AM, Atkinson, EG, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, RK, Palmer, DS, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, JI, King, D, Seed, C, Daly, MJ, Finucane, H, Bryant, S, Satterstrom, FK, Band, G, Earle, SG, Lin, S-K, Arning, N, Koelling, N, Armstrong, J, Rudkin, JK, Callier, S, Cusick, C, Soranzo, N, Zhao, JH, Danesh, J, Angelantonio, ED, Butterworth, AS, Sun, YV, Huffman, JE, Cho, K, O’Donnell, CJ, Tsao, P, Gaziano, JM, Peloso, G, Ho, Y-L, Smieszek, SP, Polymeropoulos, C, Polymeropoulos, V, Polymeropoulos, MH, Przychodzen, BP, Fernandez-Cadenas, I, Planas, AM, Perez-Tur, J, Llucià-Carol, L, Cullell, N, Muiño, E, Cárcel-Márquez, J, DeDiego, ML, Iglesias, LL, Soriano, A, Rico, V, Agüero, D, Bedini, JL, Lozano, F, Domingo, C, Robles, V, Ruiz-Jaén, F, Márquez, L, Gomez, J, Coto, E, Albaiceta, GM, García-Clemente, M, Dalmau, D, Arranz, MJ, Dietl, B, Serra-Llovich, A, Soler, P, Colobrán, R, Martín-Nalda, A, Martínez, AP, Bernardo, D, Rojo, S, Fiz-López, A, Arribas, E, de la Cal-Sabater, P, Segura, T, González-Villa, E, Serrano-Heras, G, Martí-Fàbregas, J, Jiménez-Xarrié, E, de Felipe Mimbrera, A, Masjuan, J, García-Madrona, S, Domínguez-Mayoral, A, Villalonga, JM, Menéndez-Valladares, P, Chasman, DI, Sesso, HD, Manson, JE, Buring, JE, Ridker, PM, Franco, G, Davis, L, Lee, S, Priest, J, Sankaran, VG, van Heel, D, Biesecker, L, Kerchberger, VE, Baillie, JK |
| المساهمون: | Pathak, Gita A., Karjalainen, Juha, Stevens, Christine, Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Andrews, Shea J., Kanai, Masahiro, Cordioli, Mattia, Polimanti, Renato, Harerimana, Nadia, Pirinen, Matti, Liao, Rachel G., Chwialkowska, Karolina, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Veerapen, Kumar, Wolford, Brooke, Roberts, Genevieve, Park, Danny, Ball, Catherine A., Coignet, Marie, McCurdy, Shannon, Knight, Spencer, Partha, Raghavendran, Rhead, Brooke, Zhang, Miao, Berkowitz, Nathan, Gaddis, Michael, Noto, Keith, Ruiz, Luong, Pavlovic, Milo, Hong, Eurie L., Rand, Kristin, Girshick, Ahna, Guturu, Harendra, Baltzell, Asher Haug, Niemi, Mari E. K., Rahmouni, Souad, Guntz, Julien, Beguin, Yve, Pigazzini, Sara, Nkambule, Lindokuhle, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gille, Guiot, Julien, Azarzar, Samira, Gofflot, Stéphanie, Claassen, Sabine, Malaise, Olivier, Huynen, Pascale, Meuris, Christelle, Thys, Marie, Jacques, Jessica, Léonard, Philippe, Frippiat, Frederic, Giot, Jean-Baptiste, Sauvage, Anne-Sophie, Frenckell, Christian Von, Belhaj, Yasmine, Lambermont, Bernard, Nakanishi, Tomoko, Morrison, David R., Mooser, Vincent, Richards, J. Brent, Butler-Laporte, Guillaume, Forgetta, Vincenzo, Li, Rui, Ghosh, Biswarup, Laurent, Laetitia, Belisle, Alexandre, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Loui, Tselios, Chri, Xue, Xiaoqing, Afilalo, Jonathan, Afilalo, Marc, Oliveira, Maureen, Brenner, Bluma, Brassard, Nathalie, Durand, Madeleine, Schurr, Erwin, Lepage, Pierre, Ragoussis, Jianni, Auld, Daniel, Chassé, Michaël, Kaufmann, Daniel E., Lathrop, G. Mark, Adra, Darin, Hayward, Caroline, Glessner, Joseph T., Shaw, Douglas M., Campbell, Archie, Morris, Marcela, Hakonarson, Hakon, Porteous, David J., Below, Jennifer, Richmond, Anne, Chang, Xiao, Polikowski, Hannah, Lauren, Petty E., Chen, Hung-Hsin, Wanying, Zhu, Fawns-Ritchie, Chloe, North, Kari, McCormick, Joseph B., Glessner, Joseph R., Gignoux, Christopher R., Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Daya, Michelle, Shortt, Jonathan, Rafaels, Nichola, Chavan, Sameer, Timmers, Paul R. H. J., Wilson, James F., Tenesa, Albert, Kerr, Shona M., D’Mellow, Kenton, Shahin, Doaa, El-Sherbiny, Yasser M., von Hohenstaufen, Kathrin Aprile, Sobh, Ali, Eltoukhy, Madonna M., Nkambul, Lindokuhle, Elhadidy, Tamer A., Abd Elghafar, Mohamed S., El-Jawhari, Jehan J., Mohamed, Attia A. S., Elnagdy, Marwa H., Samir, Amr, Abdel-Aziz, Mahmoud, Khafaga, Walid T., El-Lawaty, Walaa M., Torky, Mohamed S., El-shanshory, Mohamed R., Yassen, Amr M., Hegazy, Mohamed A. F., Okasha, Kamal, Eid, Mohammed A., Moahmed, Hanteera S., Medina-Gomez, Carolina, Ikram, M. Arfan, Uitterlinden, Andre G., Mägi, Reedik, Milani, Lili, Metspalu, Andre, Laisk, Triin, Läll, Kristi, Lepamets, Maarja, Esko, Tõnu, Reimann, Ene, Naaber, Paul, Laane, Edward, Pesukova, Jaana, Peterson, Pärt, Kisand, Kai, Tabri, Jekaterina, Allos, Raili, Hensen, Kati, Starkopf, Joel, Ringmets, Inge, Tamm, Anu, Kallaste, Anne, Alavere, Helene, Metsalu, Kristjan, Puusepp, Mairo, Batini, Chiara, Tobin, Martin D., Venn, Laura D., Lee, Paul H., Shrine, Nick, Williams, Alexander T., Guyatt, Anna L., John, Catherine, Packer, Richard J., Ali, Altaf, Free, Robert C., Wang, Xueyang, Wain, Louise V., Hollox, Edward J., Bee, Catherine E., Adams, Emma L., Palotie, Aarno, Ripatti, Samuli, Ruotsalainen, Sanni, Kristiansson, Kati, Koskelainen, Sami, Perola, Marku, Donner, Kati, Kivinen, Katja, Kaunisto, Mari, Rivolta, Carlo, Bochud, Pierre-Yve, Bibert, Stéphanie, Boillat, Noémie, Nussle, Semira Gonseth, Albrich, Werner, Quinodoz, Mathieu, Kamdar, Dhryata, Suh, Noémie, Neofytos, Dionysio, Erard, Véronique, Voide, Cathy, Friolet, R., Vollenweider, P., Pagani, J. L., Oddo, M., zu Bentrup, F. Meyer, Conen, A., Clerc, O., Marchetti, O., Guillet, A., Guyat-Jacques, C., Foucras, S., Rime, M., Chassot, J., Jaquet, M., Viollet, R. Merlet, Lannepoudenx, Y., Portopena, L., Bochud, P. Y., Desgranges, F., Filippidis, P., Guéry, B., Haefliger, D., Kampouri, E. E., Manuel, O., Munting, A., Papadimitriou-Olivgeris, M., Regina, J., Rochat-Stettler, L., Suttels, V., Tadini, E., Tschopp, J., Van Singer, M., Viala, B., Boillat-Blanco, N., Brahier, T., Hügli, O., Meuwly, J. Y., Pantet, O., Gonseth Nussle, S., Bochud, M., D’Acremont, V., Estoppey Younes, S., Albrich, W. C., Suh, N., Cerny, A., O’Mahony, L., von Mering, C., Frischknecht, M., Kleger, G-R., Filipovic, M., Kahlert, C. R., Wozniak, H., Negro, T. Rochat, Pugin, J., Bouras, K., Knapp, C., Egger, T., Perret, A., Montillier, P., di Bartolomeo, C., Barda, B., de Cid, Rafael, Carreras, Anna, Moreno, Victor, Kogevinas, Manoli, Galván-Femenía, Iván, Blay, Natalia, Farré, Xavier, Sumoy, Lauro, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, Gori, Marco, Renieri, Alessandra, Mari, Francesca, Mondelli, Mario Umberto, Castelli, Francesco, Vaghi, Massimo, Rusconi, Stefano, Montagnani, Francesca, Bargagli, Elena, Franchi, Federico, Mazzei, Maria Antonietta, Cantarini, Luca, Tacconi, Danilo, Feri, Marco, Scala, Raffaele, Spargi, Genni, Nencioni, Cesira, Bandini, Maria, Caldarelli, Gian Piero, Canaccini, Anna, Ognibene, Agostino, D’Arminio Monforte, Antonella, Girardis, Massimo, Antinori, Andrea, Francisci, Daniela, Schiaroli, Elisabetta, Scotton, Pier Giorgio, Panese, Sandro, Scaggiante, Renzo, Monica, Matteo Della, Capasso, Mario, Fiorentino, Giuseppe, Castori, Marco, Aucella, Filippo, Biagio, Antonio Di, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, Rovere, Maria Teresa La, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Pietro, Massimo Di, Sabrina, Ravaglia, Luchi, Sauro, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Rizzo, Caterina Lo, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Sarno, Laura Di, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazzi, Alessandro, Lorubbio, Maria, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Paciosi, Francesco, 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M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Buxbaum, Joseph D., Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. 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Eric, Baillie, J. Kenneth, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Biological Psychology, APH - Mental Health, AMS - Sports, AMS - Ageing & Vitality, APH - Methodology, Mccurdy, Shannon, Mccormick, Joseph B., Macarthur, Daniel, Maclaughlin, Bev, Lefaive, Jonathon, Almalik, Abdulaziz, Alzahrani, Deema, Aljohani, Sameera, Aldhawi, Nouf, Albardis, Hadeel, Fawzy, Mohammad S., Dediego, Marta L., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), University of Zurich, COVID-19 Host Genetics Initiative, Barcelona Supercomputing Center, COVID-19 Genetics Initiative, including authors, Institute for Molecular Medicine Finland, Data Science Genetic Epidemiology Lab |
| المصدر: | Nature, 608(7921), E1-E10. Nature Publishing Group Nature, 608. Nature Publishing Group UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Nature r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname COVID-19 Host Genetics Initiative, Hottenga, J J, Bartels, M, de Geus, E J C & Nivard, M 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7Test 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7Test |
| بيانات النشر: | Nature Publishing Group, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Quantitative Trait Loci, MUC5B PROMOTER POLYMORPHISM, Genome-wide association studies, COVID-19 (Malaltia), UFSP13-7 Evolution in Action: From Genomes to Ecosystems, COVID-19 (Disease), Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, SDG 3 - Good Health and Well-being, Humans, genetics, Genetic variation, Genomes, Medicinsk genetik, 1000 Multidisciplinary, Multidisciplinary, Chromosome Mapping, COVID-19, Human Genetics, 10124 Institute of Molecular Life Sciences, covid-19, 3121 General medicine, internal medicine and other clinical medicine, 570 Life sciences, biology, Medical Genetics |
| الوصف: | Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-xTest The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P |
| وصف الملف: | ELETTRONICO; text; application/pdf; 41586_2022_Article_4826.pdf - application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
| اللغة: | English |
| تدمد: | 0028-0836 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cbe7f6ea8d3fe660425d3d9cc06f9Test https://doi.org/10.1038/s41586-022-04826-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....827cbe7f6ea8d3fe660425d3d9cc06f9 |
| قاعدة البيانات: | OpenAIRE |
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JJ</searchLink><br /><searchLink fieldCode="AR" term="%22Mohamed%2C+AAS%22">Mohamed, AAS</searchLink><br /><searchLink fieldCode="AR" term="%22Elnagdy%2C+MH%22">Elnagdy, MH</searchLink><br /><searchLink fieldCode="AR" term="%22Samir%2C+A%22">Samir, A</searchLink><br /><searchLink fieldCode="AR" term="%22Abdel-Aziz%2C+M%22">Abdel-Aziz, M</searchLink><br /><searchLink fieldCode="AR" term="%22Khafaga%2C+WT%22">Khafaga, WT</searchLink><br /><searchLink fieldCode="AR" term="%22El-Lawaty%2C+WM%22">El-Lawaty, WM</searchLink><br /><searchLink fieldCode="AR" term="%22Torky%2C+MS%22">Torky, MS</searchLink><br /><searchLink fieldCode="AR" term="%22El-shanshory%2C+MR%22">El-shanshory, MR</searchLink><br /><searchLink fieldCode="AR" term="%22Yassen%2C+AM%22">Yassen, AM</searchLink><br /><searchLink fieldCode="AR" term="%22Hegazy%2C+MAF%22">Hegazy, MAF</searchLink><br /><searchLink fieldCode="AR" term="%22Okasha%2C+K%22">Okasha, K</searchLink><br /><searchLink fieldCode="AR" 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N</searchLink><br /><searchLink fieldCode="AR" term="%22Farré%2C+X%22">Farré, X</searchLink><br /><searchLink fieldCode="AR" term="%22Sumoy%2C+L%22">Sumoy, L</searchLink><br /><searchLink fieldCode="AR" term="%22Cortés%2C+B%22">Cortés, B</searchLink><br /><searchLink fieldCode="AR" term="%22Mercader%2C+JM%22">Mercader, JM</searchLink><br /><searchLink fieldCode="AR" term="%22Guindo-Martinez%2C+M%22">Guindo-Martinez, M</searchLink><br /><searchLink fieldCode="AR" term="%22Torrents%2C+D%22">Torrents, D</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia-Aymerich%2C+J%22">Garcia-Aymerich, J</searchLink><br /><searchLink fieldCode="AR" term="%22Castaño-Vinyals%2C+G%22">Castaño-Vinyals, G</searchLink><br /><searchLink fieldCode="AR" term="%22Dobaño%2C+C%22">Dobaño, C</searchLink><br /><searchLink fieldCode="AR" term="%22Gori%2C+M%22">Gori, M</searchLink><br /><searchLink fieldCode="AR" term="%22Renieri%2C+A%22">Renieri, A</searchLink><br /><searchLink fieldCode="AR" 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term="%22Aliannejad%2C+R%22">Aliannejad, R</searchLink><br /><searchLink fieldCode="AR" term="%22Sharififard%2C+B%22">Sharififard, B</searchLink><br /><searchLink fieldCode="AR" term="%22Amirsavadkouhi%2C+A%22">Amirsavadkouhi, A</searchLink><br /><searchLink fieldCode="AR" term="%22Naderpour%2C+Z%22">Naderpour, Z</searchLink><br /><searchLink fieldCode="AR" term="%22Tadi%2C+HA%22">Tadi, HA</searchLink><br /><searchLink fieldCode="AR" term="%22Aleagha%2C+AE%22">Aleagha, AE</searchLink><br /><searchLink fieldCode="AR" term="%22Ahmadi%2C+S%22">Ahmadi, S</searchLink><br /><searchLink fieldCode="AR" term="%22Moghaddam%2C+SBM%22">Moghaddam, SBM</searchLink><br /><searchLink fieldCode="AR" term="%22Adamsara%2C+A%22">Adamsara, A</searchLink><br /><searchLink fieldCode="AR" term="%22Saeedi%2C+M%22">Saeedi, M</searchLink><br /><searchLink fieldCode="AR" term="%22Abdollahi%2C+H%22">Abdollahi, H</searchLink><br /><searchLink fieldCode="AR" term="%22Hosseini%2C+A%22">Hosseini, A</searchLink><br 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L</searchLink><br /><searchLink fieldCode="AR" term="%22Boezen%2C+M%22">Boezen, M</searchLink><br /><searchLink fieldCode="AR" term="%22Deelen%2C+P%22">Deelen, P</searchLink><br /><searchLink fieldCode="AR" term="%22Claringbould%2C+A%22">Claringbould, A</searchLink><br /><searchLink fieldCode="AR" term="%22Lopera%2C+E%22">Lopera, E</searchLink><br /><searchLink fieldCode="AR" term="%22Warmerdam%2C+R%22">Warmerdam, R</searchLink><br /><searchLink fieldCode="AR" term="%22Vonk%2C+JM%22">Vonk, JM</searchLink><br /><searchLink fieldCode="AR" term="%22van+Blokland%2C+I%22">van Blokland, I</searchLink><br /><searchLink fieldCode="AR" term="%22Lanting%2C+P%22">Lanting, P</searchLink><br /><searchLink fieldCode="AR" term="%22Ori%2C+APS%22">Ori, APS</searchLink><br /><searchLink fieldCode="AR" term="%22Feng%2C+Y-CA%22">Feng, Y-CA</searchLink><br /><searchLink fieldCode="AR" term="%22Mercader%2C+J%22">Mercader, J</searchLink><br /><searchLink fieldCode="AR" term="%22Weiss%2C+ST%22">Weiss, ST</searchLink><br /><searchLink fieldCode="AR" term="%22Karlson%2C+EW%22">Karlson, EW</searchLink><br /><searchLink fieldCode="AR" term="%22Smoller%2C+JW%22">Smoller, JW</searchLink><br /><searchLink fieldCode="AR" term="%22Murphy%2C+SN%22">Murphy, SN</searchLink><br /><searchLink fieldCode="AR" term="%22Meigs%2C+JB%22">Meigs, JB</searchLink><br /><searchLink fieldCode="AR" term="%22Woolley%2C+AE%22">Woolley, AE</searchLink><br /><searchLink fieldCode="AR" term="%22Green%2C+RC%22">Green, RC</searchLink><br /><searchLink fieldCode="AR" term="%22Perez%2C+EF%22">Perez, EF</searchLink><br /><searchLink fieldCode="AR" term="%22Zöllner%2C+S%22">Zöllner, S</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+J%22">Wang, J</searchLink><br /><searchLink fieldCode="AR" term="%22Beck%2C+A%22">Beck, A</searchLink><br /><searchLink fieldCode="AR" term="%22Sloofman%2C+LG%22">Sloofman, LG</searchLink><br /><searchLink fieldCode="AR" term="%22Ascolillo%2C+S%22">Ascolillo, S</searchLink><br 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term="%22O%27Donnell%2C+CJ%22">O’Donnell, CJ</searchLink><br /><searchLink fieldCode="AR" term="%22Tsao%2C+P%22">Tsao, P</searchLink><br /><searchLink fieldCode="AR" term="%22Gaziano%2C+JM%22">Gaziano, JM</searchLink><br /><searchLink fieldCode="AR" term="%22Peloso%2C+G%22">Peloso, G</searchLink><br /><searchLink fieldCode="AR" term="%22Ho%2C+Y-L%22">Ho, Y-L</searchLink><br /><searchLink fieldCode="AR" term="%22Smieszek%2C+SP%22">Smieszek, SP</searchLink><br /><searchLink fieldCode="AR" term="%22Polymeropoulos%2C+C%22">Polymeropoulos, C</searchLink><br /><searchLink fieldCode="AR" term="%22Polymeropoulos%2C+V%22">Polymeropoulos, V</searchLink><br /><searchLink fieldCode="AR" term="%22Polymeropoulos%2C+MH%22">Polymeropoulos, MH</searchLink><br /><searchLink fieldCode="AR" term="%22Przychodzen%2C+BP%22">Przychodzen, BP</searchLink><br /><searchLink fieldCode="AR" term="%22Fernandez-Cadenas%2C+I%22">Fernandez-Cadenas, I</searchLink><br /><searchLink fieldCode="AR" term="%22Planas%2C+AM%22">Planas, AM</searchLink><br /><searchLink fieldCode="AR" term="%22Perez-Tur%2C+J%22">Perez-Tur, J</searchLink><br /><searchLink fieldCode="AR" term="%22Llucià-Carol%2C+L%22">Llucià-Carol, L</searchLink><br /><searchLink fieldCode="AR" term="%22Cullell%2C+N%22">Cullell, N</searchLink><br /><searchLink fieldCode="AR" term="%22Muiño%2C+E%22">Muiño, E</searchLink><br /><searchLink fieldCode="AR" term="%22Cárcel-Márquez%2C+J%22">Cárcel-Márquez, J</searchLink><br /><searchLink fieldCode="AR" term="%22DeDiego%2C+ML%22">DeDiego, ML</searchLink><br /><searchLink fieldCode="AR" term="%22Iglesias%2C+LL%22">Iglesias, LL</searchLink><br /><searchLink fieldCode="AR" term="%22Soriano%2C+A%22">Soriano, A</searchLink><br /><searchLink fieldCode="AR" term="%22Rico%2C+V%22">Rico, V</searchLink><br /><searchLink fieldCode="AR" term="%22Agüero%2C+D%22">Agüero, D</searchLink><br /><searchLink fieldCode="AR" term="%22Bedini%2C+JL%22">Bedini, JL</searchLink><br /><searchLink 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fieldCode="AR" term="%22Serra-Llovich%2C+A%22">Serra-Llovich, A</searchLink><br /><searchLink fieldCode="AR" term="%22Soler%2C+P%22">Soler, P</searchLink><br /><searchLink fieldCode="AR" term="%22Colobrán%2C+R%22">Colobrán, R</searchLink><br /><searchLink fieldCode="AR" term="%22Martín-Nalda%2C+A%22">Martín-Nalda, A</searchLink><br /><searchLink fieldCode="AR" term="%22Martínez%2C+AP%22">Martínez, AP</searchLink><br /><searchLink fieldCode="AR" term="%22Bernardo%2C+D%22">Bernardo, D</searchLink><br /><searchLink fieldCode="AR" term="%22Rojo%2C+S%22">Rojo, S</searchLink><br /><searchLink fieldCode="AR" term="%22Fiz-López%2C+A%22">Fiz-López, A</searchLink><br /><searchLink fieldCode="AR" term="%22Arribas%2C+E%22">Arribas, E</searchLink><br /><searchLink fieldCode="AR" term="%22de+la+Cal-Sabater%2C+P%22">de la Cal-Sabater, P</searchLink><br /><searchLink fieldCode="AR" term="%22Segura%2C+T%22">Segura, T</searchLink><br /><searchLink fieldCode="AR" term="%22González-Villa%2C+E%22">González-Villa, E</searchLink><br /><searchLink fieldCode="AR" term="%22Serrano-Heras%2C+G%22">Serrano-Heras, G</searchLink><br /><searchLink fieldCode="AR" term="%22Martí-Fàbregas%2C+J%22">Martí-Fàbregas, J</searchLink><br /><searchLink fieldCode="AR" term="%22Jiménez-Xarrié%2C+E%22">Jiménez-Xarrié, E</searchLink><br /><searchLink fieldCode="AR" term="%22de+Felipe+Mimbrera%2C+A%22">de Felipe Mimbrera, A</searchLink><br /><searchLink fieldCode="AR" term="%22Masjuan%2C+J%22">Masjuan, J</searchLink><br /><searchLink fieldCode="AR" term="%22García-Madrona%2C+S%22">García-Madrona, S</searchLink><br /><searchLink fieldCode="AR" term="%22Domínguez-Mayoral%2C+A%22">Domínguez-Mayoral, A</searchLink><br /><searchLink fieldCode="AR" term="%22Villalonga%2C+JM%22">Villalonga, JM</searchLink><br /><searchLink fieldCode="AR" term="%22Menéndez-Valladares%2C+P%22">Menéndez-Valladares, P</searchLink><br /><searchLink fieldCode="AR" term="%22Chasman%2C+DI%22">Chasman, DI</searchLink><br /><searchLink fieldCode="AR" term="%22Sesso%2C+HD%22">Sesso, HD</searchLink><br /><searchLink fieldCode="AR" term="%22Manson%2C+JE%22">Manson, JE</searchLink><br /><searchLink fieldCode="AR" term="%22Buring%2C+JE%22">Buring, JE</searchLink><br /><searchLink fieldCode="AR" term="%22Ridker%2C+PM%22">Ridker, PM</searchLink><br /><searchLink fieldCode="AR" term="%22Franco%2C+G%22">Franco, G</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+L%22">Davis, L</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+S%22">Lee, S</searchLink><br /><searchLink fieldCode="AR" term="%22Priest%2C+J%22">Priest, J</searchLink><br /><searchLink fieldCode="AR" term="%22Sankaran%2C+VG%22">Sankaran, VG</searchLink><br /><searchLink fieldCode="AR" term="%22van+Heel%2C+D%22">van Heel, D</searchLink><br /><searchLink fieldCode="AR" term="%22Biesecker%2C+L%22">Biesecker, L</searchLink><br /><searchLink fieldCode="AR" term="%22Kerchberger%2C+VE%22">Kerchberger, VE</searchLink><br /><searchLink fieldCode="AR" term="%22Baillie%2C+JK%22">Baillie, JK</searchLink> ) Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Pathak, Gita A.<br />Karjalainen, Juha<br />Stevens, Christine<br />Neale, Benjamin M.<br />Daly, Mark<br />Ganna, Andrea<br />Andrews, Shea J.<br />Kanai, Masahiro<br />Cordioli, Mattia<br />Polimanti, Renato<br />Harerimana, Nadia<br />Pirinen, Matti<br />Liao, Rachel G.<br />Chwialkowska, Karolina<br />Trankiem, Amy<br />Balaconis, Mary K.<br />Nguyen, Huy<br />Solomonson, Matthew<br />Veerapen, Kumar<br />Wolford, Brooke<br />Roberts, Genevieve<br />Park, Danny<br />Ball, Catherine A.<br />Coignet, Marie<br />McCurdy, Shannon<br />Knight, Spencer<br />Partha, Raghavendran<br />Rhead, Brooke<br />Zhang, Miao<br />Berkowitz, Nathan<br />Gaddis, Michael<br />Noto, Keith<br />Ruiz, Luong<br />Pavlovic, Milo<br />Hong, Eurie L.<br />Rand, Kristin<br />Girshick, Ahna<br />Guturu, Harendra<br />Baltzell, Asher Haug<br />Niemi, Mari E. K.<br />Rahmouni, Souad<br />Guntz, Julien<br />Beguin, Yve<br />Pigazzini, Sara<br />Nkambule, Lindokuhle<br />Georges, Michel<br />Moutschen, Michel<br />Misset, Benoit<br />Darcis, Gille<br />Guiot, Julien<br />Azarzar, Samira<br />Gofflot, Stéphanie<br />Claassen, Sabine<br />Malaise, Olivier<br />Huynen, Pascale<br />Meuris, Christelle<br />Thys, Marie<br />Jacques, Jessica<br />Léonard, Philippe<br />Frippiat, Frederic<br />Giot, Jean-Baptiste<br />Sauvage, Anne-Sophie<br />Frenckell, Christian Von<br />Belhaj, Yasmine<br />Lambermont, Bernard<br />Nakanishi, Tomoko<br />Morrison, David R.<br />Mooser, Vincent<br />Richards, J. Brent<br />Butler-Laporte, Guillaume<br />Forgetta, Vincenzo<br />Li, Rui<br />Ghosh, Biswarup<br />Laurent, Laetitia<br />Belisle, Alexandre<br />Henry, Danielle<br />Abdullah, Tala<br />Adeleye, Olumide<br />Mamlouk, Noor<br />Kimchi, Nofar<br />Afrasiabi, Zaman<br />Rezk, Nardin<br />Vulesevic, Branka<br />Bouab, Meriem<br />Guzman, Charlotte<br />Petitjean, Loui<br />Tselios, Chri<br />Xue, Xiaoqing<br />Afilalo, Jonathan<br />Afilalo, Marc<br />Oliveira, Maureen<br />Brenner, Bluma<br />Brassard, Nathalie<br />Durand, Madeleine<br />Schurr, Erwin<br />Lepage, Pierre<br />Ragoussis, Jianni<br />Auld, Daniel<br />Chassé, Michaël<br />Kaufmann, Daniel E.<br />Lathrop, G. Mark<br />Adra, Darin<br />Hayward, Caroline<br />Glessner, Joseph T.<br />Shaw, Douglas M.<br />Campbell, Archie<br />Morris, Marcela<br />Hakonarson, Hakon<br />Porteous, David J.<br />Below, Jennifer<br />Richmond, Anne<br />Chang, Xiao<br />Polikowski, Hannah<br />Lauren, Petty E.<br />Chen, Hung-Hsin<br />Wanying, Zhu<br />Fawns-Ritchie, Chloe<br />North, Kari<br />McCormick, Joseph B.<br />Glessner, Joseph R.<br />Gignoux, Christopher R.<br />Wicks, Stephen J.<br />Crooks, Kristy<br />Barnes, Kathleen C.<br />Daya, Michelle<br />Shortt, Jonathan<br />Rafaels, Nichola<br />Chavan, Sameer<br />Timmers, Paul R. H. J.<br />Wilson, James F.<br />Tenesa, Albert<br />Kerr, Shona M.<br />D’Mellow, Kenton<br />Shahin, Doaa<br />El-Sherbiny, Yasser M.<br />von Hohenstaufen, Kathrin Aprile<br />Sobh, Ali<br />Eltoukhy, Madonna M.<br />Nkambul, Lindokuhle<br />Elhadidy, Tamer A.<br />Abd Elghafar, Mohamed S.<br />El-Jawhari, Jehan J.<br />Mohamed, Attia A. S.<br />Elnagdy, Marwa H.<br />Samir, Amr<br />Abdel-Aziz, Mahmoud<br />Khafaga, Walid T.<br />El-Lawaty, Walaa M.<br />Torky, Mohamed S.<br />El-shanshory, Mohamed R.<br />Yassen, Amr M.<br />Hegazy, Mohamed A. F.<br />Okasha, Kamal<br />Eid, Mohammed A.<br />Moahmed, Hanteera S.<br />Medina-Gomez, Carolina<br />Ikram, M. Arfan<br />Uitterlinden, Andre G.<br />Mägi, Reedik<br />Milani, Lili<br />Metspalu, Andre<br />Laisk, Triin<br />Läll, Kristi<br />Lepamets, Maarja<br />Esko, Tõnu<br />Reimann, Ene<br />Naaber, Paul<br />Laane, Edward<br />Pesukova, Jaana<br />Peterson, Pärt<br />Kisand, Kai<br />Tabri, Jekaterina<br />Allos, Raili<br />Hensen, Kati<br />Starkopf, Joel<br />Ringmets, Inge<br />Tamm, Anu<br />Kallaste, Anne<br />Alavere, Helene<br />Metsalu, Kristjan<br />Puusepp, Mairo<br />Batini, Chiara<br />Tobin, Martin D.<br />Venn, Laura D.<br />Lee, Paul H.<br />Shrine, Nick<br />Williams, Alexander T.<br />Guyatt, Anna L.<br />John, Catherine<br />Packer, Richard J.<br />Ali, Altaf<br />Free, Robert C.<br />Wang, Xueyang<br />Wain, Louise V.<br />Hollox, Edward J.<br />Bee, Catherine E.<br />Adams, Emma L.<br />Palotie, Aarno<br />Ripatti, Samuli<br />Ruotsalainen, Sanni<br />Kristiansson, Kati<br />Koskelainen, Sami<br />Perola, Marku<br />Donner, Kati<br />Kivinen, Katja<br />Kaunisto, Mari<br />Rivolta, Carlo<br />Bochud, Pierre-Yve<br />Bibert, Stéphanie<br />Boillat, Noémie<br />Nussle, Semira Gonseth<br />Albrich, Werner<br />Quinodoz, Mathieu<br />Kamdar, Dhryata<br />Suh, Noémie<br />Neofytos, Dionysio<br />Erard, Véronique<br />Voide, Cathy<br />Friolet, R.<br />Vollenweider, P.<br />Pagani, J. L.<br />Oddo, M.<br />zu Bentrup, F. Meyer<br />Conen, A.<br />Clerc, O.<br />Marchetti, O.<br />Guillet, A.<br />Guyat-Jacques, C.<br />Foucras, S.<br />Rime, M.<br />Chassot, J.<br />Jaquet, M.<br />Viollet, R. Merlet<br />Lannepoudenx, Y.<br />Portopena, L.<br />Bochud, P. Y.<br />Desgranges, F.<br />Filippidis, P.<br />Guéry, B.<br />Haefliger, D.<br />Kampouri, E. E.<br />Manuel, O.<br />Munting, A.<br />Papadimitriou-Olivgeris, M.<br />Regina, J.<br />Rochat-Stettler, L.<br />Suttels, V.<br />Tadini, E.<br />Tschopp, J.<br />Van Singer, M.<br />Viala, B.<br />Boillat-Blanco, N.<br />Brahier, T.<br />Hügli, O.<br />Meuwly, J. Y.<br />Pantet, O.<br />Gonseth Nussle, S.<br />Bochud, M.<br />D’Acremont, V.<br />Estoppey Younes, S.<br />Albrich, W. C.<br />Suh, N.<br />Cerny, A.<br />O’Mahony, L.<br />von Mering, C.<br />Frischknecht, M.<br />Kleger, G-R.<br />Filipovic, M.<br />Kahlert, C. R.<br />Wozniak, H.<br />Negro, T. Rochat<br />Pugin, J.<br />Bouras, K.<br />Knapp, C.<br />Egger, T.<br />Perret, A.<br />Montillier, P.<br />di Bartolomeo, C.<br />Barda, B.<br />de Cid, Rafael<br />Carreras, Anna<br />Moreno, Victor<br />Kogevinas, Manoli<br />Galván-Femenía, Iván<br />Blay, Natalia<br />Farré, Xavier<br />Sumoy, Lauro<br />Cortés, Beatriz<br />Mercader, Josep Maria<br />Guindo-Martinez, Marta<br />Torrents, David<br />Garcia-Aymerich, Judith<br />Castaño-Vinyals, Gemma<br />Dobaño, Carlota<br />Gori, Marco<br />Renieri, Alessandra<br />Mari, Francesca<br />Mondelli, Mario Umberto<br />Castelli, Francesco<br />Vaghi, Massimo<br />Rusconi, Stefano<br />Montagnani, Francesca<br />Bargagli, Elena<br />Franchi, Federico<br />Mazzei, Maria Antonietta<br />Cantarini, Luca<br />Tacconi, Danilo<br />Feri, Marco<br />Scala, Raffaele<br />Spargi, Genni<br />Nencioni, Cesira<br />Bandini, Maria<br />Caldarelli, Gian Piero<br />Canaccini, Anna<br />Ognibene, Agostino<br />D’Arminio Monforte, Antonella<br />Girardis, Massimo<br />Antinori, Andrea<br />Francisci, Daniela<br />Schiaroli, Elisabetta<br />Scotton, Pier Giorgio<br />Panese, Sandro<br />Scaggiante, Renzo<br />Monica, Matteo Della<br />Capasso, Mario<br />Fiorentino, Giuseppe<br />Castori, Marco<br />Aucella, Filippo<br />Biagio, Antonio Di<br />Masucci, Luca<br />Valente, Serafina<br />Mandalà, Marco<br />Zucchi, Patrizia<br />Giannattasio, Ferdinando<br />Coviello, Domenico A.<br />Mussini, Cristina<br />Tavecchia, Luisa<br />Crotti, Lia<br />Rizzi, Marco<br />Rovere, Maria Teresa La<br />Sarzi-Braga, Simona<br />Bussotti, Maurizio<br />Ravaglia, Sabrina<br />Artuso, Rosangela<br />Perrella, Antonio<br />Romani, Davide<br />Bergomi, Paola<br />Catena, Emanuele<br />Vincenti, Antonella<br />Ferri, Claudio<br />Grassi, Davide<br />Pessina, Gloria<br />Tumbarello, Mario<br />Pietro, Massimo Di<br />Sabrina, Ravaglia<br />Luchi, Sauro<br />Furini, Simone<br />Dei, Simona<br />Benetti, Elisa<br />Picchiotti, Nicola<br />Sanarico, 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Eric<br />Baillie, J. Kenneth<br />APH - Personalized Medicine<br />APH - Health Behaviors & Chronic Diseases<br />Biological Psychology<br />APH - Mental Health<br />AMS - Sports<br />AMS - Ageing & Vitality<br />APH - Methodology<br />Mccurdy, Shannon<br />Mccormick, Joseph B.<br />Macarthur, Daniel<br />Maclaughlin, Bev<br />Lefaive, Jonathon<br />Almalik, Abdulaziz<br />Alzahrani, Deema<br />Aljohani, Sameera<br />Aldhawi, Nouf<br />Albardis, Hadeel<br />Fawzy, Mohammad S.<br />Dediego, Marta L.<br />Stem Cell Aging Leukemia and Lymphoma (SALL)<br />Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)<br />Life Course Epidemiology (LCE)<br />Groningen Research Institute for Asthma and COPD (GRIAC)<br />University of Zurich<br />COVID-19 Host Genetics Initiative<br />Barcelona Supercomputing Center<br />COVID-19 Genetics Initiative<br />including authors<br />Institute for Molecular Medicine Finland<br />Data Science Genetic Epidemiology Lab ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Nature, 608(7921), E1-E10. Nature Publishing Group<br />Nature, 608. Nature Publishing Group<br />UPCommons. Portal del coneixement obert de la UPC<br />Universitat Politècnica de Catalunya (UPC)<br />Nature<br />r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe<br />instname<br />COVID-19 Host Genetics Initiative, Hottenga, J J, Bartels, M, de Geus, E J C & Nivard, M 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7<br />2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Nature Publishing Group, 2022. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Informàtica%3A%3AAplicacions+de+la+informàtica%3A%3ABioinformàtica+[Àrees+temàtiques+de+la+UPC]%22">Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]</searchLink><br /><searchLink fieldCode="DE" term="%22Quantitative+Trait+Loci%22">Quantitative Trait Loci</searchLink><br /><searchLink fieldCode="DE" term="%22MUC5B+PROMOTER+POLYMORPHISM%22">MUC5B PROMOTER POLYMORPHISM</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-wide+association+studies%22">Genome-wide association studies</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+%28Malaltia%29%22">COVID-19 (Malaltia)</searchLink><br /><searchLink fieldCode="DE" term="%22UFSP13-7+Evolution+in+Action%3A+From+Genomes+to+Ecosystems%22">UFSP13-7 Evolution in Action: From Genomes to Ecosystems</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+%28Disease%29%22">COVID-19 (Disease)</searchLink><br /><searchLink fieldCode="DE" term="%22Settore+BIO%2F12+-+BIOCHIMICA+CLINICA+E+BIOLOGIA+MOLECOLARE+CLINICA%22">Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA</searchLink><br /><searchLink fieldCode="DE" term="%22SDG+3+-+Good+Health+and+Well-being%22">SDG 3 - Good Health and Well-being</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22genetics%22">genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Medicinsk+genetik%22">Medicinsk genetik</searchLink><br /><searchLink fieldCode="DE" term="%221000+Multidisciplinary%22">1000 Multidisciplinary</searchLink><br /><searchLink fieldCode="DE" term="%22Multidisciplinary%22">Multidisciplinary</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosome+Mapping%22">Chromosome Mapping</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Human+Genetics%22">Human Genetics</searchLink><br /><searchLink fieldCode="DE" term="%2210124+Institute+of+Molecular+Life+Sciences%22">10124 Institute of Molecular Life Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22covid-19%22">covid-19</searchLink><br /><searchLink fieldCode="DE" term="%223121+General+medicine%2C+internal+medicine+and+other+clinical+medicine%22">3121 General medicine, internal medicine and other clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22570+Life+sciences%22">570 Life sciences</searchLink><br /><searchLink fieldCode="DE" term="%22biology%22">biology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+Genetics%22">Medical Genetics</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P ) Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => ELETTRONICO; text; application/pdf; 41586_2022_Article_4826.pdf - application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0028-0836 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cbe7f6ea8d3fe660425d3d9cc06f9" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cbe7f6ea8d3fe660425d3d9cc06f9</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1038/s41586-022-04826-7" linkWindow="_blank">https://doi.org/10.1038/s41586-022-04826-7</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....827cbe7f6ea8d3fe660425d3d9cc06f9 ) |
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[Name] => Array
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[NameFull] => including authors
)
)
)
[1694] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Institute for Molecular Medicine Finland
)
)
)
[1695] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Data Science Genetic Epidemiology Lab
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 04
[M] => 08
[Type] => published
[Y] => 2022
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00280836
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
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[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
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[Numbering] => Array
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[0] => Array
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[Type] => volume
[Value] => 608
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[1] => Array
(
[Type] => issue
[Value] => 7921
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)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Nature
[Type] => main
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)
)
)
)
)
)
|
| IllustrationInfo |