Asymmetric Dimethylarginin (ADMA) as a Marker of Endothelial Dysfunction in Primary Aldosteronism
| العنوان: | Asymmetric Dimethylarginin (ADMA) as a Marker of Endothelial Dysfunction in Primary Aldosteronism |
|---|---|
| المؤلفون: | Joanna Matrozova, Atanaska Elenkova, Silvia Vandeva, Vladimir Vasilev, Georgi Kirilov, Sabina Zaharieva |
| المصدر: | International Journal of Endocrinology and Metabolism |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Endothelial Dysfunction, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Essential hypertension, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Primary aldosteronism, Statistical significance, Internal medicine, medicine, In patient, 030212 general & internal medicine, Endothelial dysfunction, Primary Aldosteronism, business.industry, Asymmetric Dimethylarginine, medicine.disease, Kowsar, Endocrinology, chemistry, Hypertension, Etiology, business, Asymmetric dimethylarginine, Research Article |
| الوصف: | Background Recent studies have revealed a higher rate of cardiovascular complications in primary aldosteronism (PA) compared to patients with essential hypertension (EH). Asymmetric dimethylarginine (ADMA) is a marker of endothelial dysfunction that could contribute to increased cardiovascular risk in patients with PA. Objectives The aim of this study was to compare the levels of ADMA among patients with PA, controls with EH and healthy participants. Methods: Serum ADMA levels were determined, using commercially available competitive enzyme-linked immunosorbent assay. Methods Serum ADMA levels were determined, using commercially available competitive enzyme-linked immunosorbent assay. Results Patients with PA had significantly higher concentrations of ADMA than healthy controls (0.488 ± 0.085 vs. 0.433 ± 0.053 μmol/L, P = 0.027). No difference was found in ADMA levels between cases with PA and EH (0.488 ± 0.085 vs. 0.476 ± 0.075 μmol/L, р = 0.636). The difference between patients with EH and normotensive controls did not reach statistical significance (P = 0.06). Conclusions The lack of difference between ADMA levels in patients with PA and EH suggests that endothelial dysfunction is more likely related to hypertension per se than to the specific etiology of elevated blood pressure. |
| تدمد: | 1726-913X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e36c425e3297a53771417de4ca574fTest https://pubmed.ncbi.nlm.nih.gov/28123434Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....81e36c425e3297a53771417de4ca574f |
| قاعدة البيانات: | OpenAIRE |
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