Pharmacologically Directed Cell Disposal: Labeling Damaged Cells for Phagocytosis as a Strategy against Acute Pancreatitis
العنوان: | Pharmacologically Directed Cell Disposal: Labeling Damaged Cells for Phagocytosis as a Strategy against Acute Pancreatitis |
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المؤلفون: | Alexei V. Tepikin, Michael Chvanov, Ole H. Petersen |
المصدر: | Molecular Interventions. 10:80-85 |
بيانات النشر: | CLOCKSS Archive, 2010. |
سنة النشر: | 2010 |
مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Cell signaling, Necrosis, Pancreatitis, Acute Necrotizing, business.industry, Phagocytosis, Cell, Autophagy, Apoptosis, Disease, medicine.disease, Models, Biological, Viewpoints, medicine.anatomical_structure, Humans, Molecular Medicine, Medicine, Acute pancreatitis, medicine.symptom, business |
الوصف: | Acute pancreatitis is a common clinical condition, which lacks effective pharmacological treatment. The severity of the disease is determined by the extent of necrotic death of pancreatic acinar cells. This article discusses the idea of developing new pharmacological tools against acute pancreatitis by labeling necrotic pancreatic acinar with apoptotic “eat-me” signaling molecules. This approach could facilitate removal of dead material without activation of inflammatory response and thus would eliminate the main source of damage to the body during acute pancreatitis. |
تدمد: | 1534-0384 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dc242da1e943546060a798881372d5Test https://doi.org/10.1124/mi.10.2.9Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....81dc242da1e943546060a798881372d5 |
قاعدة البيانات: | OpenAIRE |
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