The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
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Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Liwu+Fu%22">Liwu Fu</searchLink><br /><searchLink fieldCode="AR" term="%22Hong+Zhang%22">Hong Zhang</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)<br />Acta Pharmaceutica Sinica. B ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier BV, 2021. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22FANCD2%2C+Fanconi+anemia+protein%22">FANCD2, Fanconi anemia protein</searchLink><br /><searchLink fieldCode="DE" term="%22DFS%2C+disease-free+survival%22">DFS, disease-free survival</searchLink><br /><searchLink fieldCode="DE" term="%22HNC%2C+head+and+neck+cancer%22">HNC, head and neck cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+therapy%22">Cancer therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Review%22">Review</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%5Fcause%22">medicine.disease_cause</searchLink><br /><searchLink fieldCode="DE" term="%22SCC%2C+squamous+cell+carcinoma%22">SCC, squamous cell 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/><searchLink fieldCode="DE" term="%22FA%2C+Fanconi+anemia%22">FA, Fanconi anemia</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22TGF-β%2C+transforming+growth+factor+β%22">TGF-β, transforming growth factor β</searchLink><br /><searchLink fieldCode="DE" term="%220303+health+sciences%22">0303 health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Progression%22">Progression</searchLink><br /><searchLink fieldCode="DE" term="%22GCA%2C+gastric+cancer%22">GCA, gastric cancer</searchLink><br /><searchLink fieldCode="DE" term="%22NRF2%2C+nuclear+factor+erythroid+2+%28NF-E2%29-related+factor+2%22">NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2</searchLink><br /><searchLink fieldCode="DE" term="%22ccRCC%2C+clear-cell+renal+cell+carcinomas%22">ccRCC, clear-cell renal cell carcinomas</searchLink><br /><searchLink fieldCode="DE" term="%22NHEJ%2C+non-homologous+end-joining%22">NHEJ, non-homologous end-joining</searchLink><br /><searchLink fieldCode="DE" term="%22PC%2C+pancreatic+cancer%22">PC, pancreatic cancer</searchLink><br /><searchLink fieldCode="DE" term="%22030220+oncology+%26+carcinogenesis%22">030220 oncology & carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22CRC%2C+colorectal+cancer%22">CRC, colorectal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22NeG%2C+1%2CN2-etheno-dGuo%22">NeG, 1,N2-etheno-dGuo</searchLink><br /><searchLink fieldCode="DE" term="%22PBMC%2C+peripheral+blood+mononuclear+cell%22">PBMC, peripheral blood mononuclear cell</searchLink><br /><searchLink fieldCode="DE" term="%22ALD%2C+alcoholic+liver+disease%22">ALD, alcoholic liver disease</searchLink><br /><searchLink fieldCode="DE" term="%22CSCs%2C+cancer+stem+cells%22">CSCs, cancer stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22OvCa%2C+ovarian+cancer%22">OvCa, ovarian cancer</searchLink><br /><searchLink fieldCode="DE" term="%22COUP-TF%2C+chicken+ovalbumin+upstream+promoter-transcription+factor%22">COUP-TF, chicken ovalbumin upstream promoter-transcription factor</searchLink><br /><searchLink fieldCode="DE" term="%22BCa%2C+bladder+cancer%22">BCa, bladder cancer</searchLink><br /><searchLink fieldCode="DE" term="%22NF-κB%2C+nuclear+factor-κB%22">NF-κB, nuclear factor-κB</searchLink><br /><searchLink fieldCode="DE" term="%22Single-nucleotide+polymorphism%22">Single-nucleotide polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Acetaldehyde%22">Acetaldehyde</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink><br /><searchLink fieldCode="DE" term="%224-HNE%2C+4-hydroxy-2-nonenal%22">4-HNE, 4-hydroxy-2-nonenal</searchLink><br /><searchLink fieldCode="DE" term="%22OS%2C+overall+survival%22">OS, overall survival</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22NSCLC%2C+non-small-cell+lung%22">NSCLC, non-small-cell lung</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22SNP%22">SNP</searchLink><br /><searchLink fieldCode="DE" term="%22MN%2C+micronuclei%22">MN, micronuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%22">Polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22ALDH2%22">ALDH2</searchLink><br /><searchLink fieldCode="DE" term="%22030304+developmental+biology%22">030304 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22LCSCs%2C+liver+cancer+stem+cells%22">LCSCs, liver cancer stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22MDA%2C+malondialdehyde%22">MDA, malondialdehyde</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22ALDH2%2C+aldehyde+dehydrogenase+2%22">ALDH2, aldehyde dehydrogenase 2</searchLink><br /><searchLink fieldCode="DE" term="%22MDR%2C+multi-drug+resistance%22">MDR, multi-drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22OPC%2C+oropharyngeal+cancer%22">OPC, oropharyngeal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22HDACs%2C+histone+deacetylases%22">HDACs, histone deacetylases</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22AMPK%2C+AMP-activated+protein+kinase%22">AMPK, AMP-activated protein kinase</searchLink><br /><searchLink fieldCode="DE" term="%22VHL%2C+von+Hippel-Lindau%22">VHL, von Hippel-Lindau</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+progression%22">Tumor progression</searchLink><br /><searchLink fieldCode="DE" term="%22REV1%2C+Y-family+DNA+polymerase%22">REV1, Y-family DNA polymerase</searchLink><br /><searchLink fieldCode="DE" term="%22NER%2C+nucleotide+excision+repair+pathway%22">NER, nucleotide excision repair pathway</searchLink><br /><searchLink fieldCode="DE" term="%22NRRE%2C+nuclear+receptor+response+element%22">NRRE, nuclear receptor response element</searchLink><br /><searchLink fieldCode="DE" term="%22Tumorigenesis%22">Tumorigenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+research%22">Cancer research</searchLink><br /><searchLink fieldCode="DE" term="%22NCEs%2C+normochromic+erythrocytes%22">NCEs, normochromic erythrocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22HR%2C+homologous+recombination%22">HR, homologous recombination</searchLink><br /><searchLink fieldCode="DE" term="%22HCC%2C+hepatocellular+carcinoma%22">HCC, hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22HNF-4%2C+hepatocyte+nuclear+factor+4%22">HNF-4, hepatocyte nuclear factor 4</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported. Either low or high ALDH2 expression contributes to tumor progression and varies among different tumor types. Furthermore, the ALDH2∗2 polymorphism (rs671) is the most common single nucleotide polymorphism (SNP) in Asia. Epidemiological studies associate ALDH2∗2 with tumorigenesis and progression. This study summarizes the essential functions and potential ALDH2 mechanisms in the occurrence, progression, and treatment of tumors in various types of cancer. Our study indicates that ALDH2 is a potential therapeutic target for cancer therapy.<br />Graphical abstract ALDH2 dysfunction contributes to the occurrence and development of cancer. A better understanding of the relationship between ALDH2 and cancer can provide a new strategies of treating cancer patients by targeting ALDH2.Image 1 ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2211-3835 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1016/j.apsb.2021.02.008" linkWindow="_blank">https://doi.org/10.1016/j.apsb.2021.02.008</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....7dd88ae6dedbdf2435fcfad1324d1900 ) |
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