Cimetidine-induced seizures in mice antagonism by some gabaergic agents
العنوان: | Cimetidine-induced seizures in mice antagonism by some gabaergic agents |
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المؤلفون: | George Amabeoku, Ordias Chikuni |
المصدر: | Biochemical Pharmacology. 46:2171-2175 |
بيانات النشر: | Elsevier BV, 1993. |
سنة النشر: | 1993 |
مصطلحات موضوعية: | Phenytoin, Baclofen, medicine.medical_specialty, Pharmacology, Bicuculline, Biochemistry, Mice, chemistry.chemical_compound, Epilepsy, Receptors, GABA, Seizures, Internal medicine, Convulsion, medicine, Animals, Picrotoxin, heterocyclic compounds, Diazepam, Muscimol, Aminobutyrates, Aminooxyacetic Acid, Strychnine, medicine.disease, Aminooxyacetic acid, Endocrinology, nervous system, chemistry, Phenobarbital, Female, medicine.symptom, Cimetidine, medicine.drug |
الوصف: | The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice. Cimetidine (400–1000 mg/kg, i.p.) induced dose-dependent tonic convulsion. Muscimol, AOAA and DABA effectively protected mice against cimetidine-induced seizures. Bicuculline and picrotoxin significantly potentiated the seizures induced by cimetidine and effectively antagonized the protective effects of muscinol, AOAA and DABA against the seizures. Diazepam and phenobarbitone significantly protected the mice against cimetidine-induced seizures while phenytoin and strychnine did not significantly alter the seizures. These results indicate that the attenuation of central γ-aminobutyric acid neurotransmission may underlie cimetidine-induced seizures in mice. |
تدمد: | 0006-2952 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784f401f39c2fb68099ecb74f88c5403Test https://doi.org/10.1016/0006-2952Test(93)90606-w |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....784f401f39c2fb68099ecb74f88c5403 |
قاعدة البيانات: | OpenAIRE |
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