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N-terminal pro brain natriuretic peptide reflects long-term complications in type 1 diabetes

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العنوان:	N-terminal pro brain natriuretic peptide reflects long-term complications in type 1 diabetes
المؤلفون:	Anders Green, Anne Katrin Sjølie, Mads Nybo, Jakob Grauslund
المصدر:	Grauslund, J, Nybo, M, Green, A & Sjølie, A K 2010, ' N-terminal pro brain natriuretic peptide reflects long-term complications in type 1 diabetes ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 70, no. 6, pp. 392-8 .
بيانات النشر:	Informa UK Limited, 2010.
سنة النشر:	2010
مصطلحات موضوعية:	Adult, Male, medicine.medical_specialty, Clinical Biochemistry, Population, Blood Pressure, Gastroenterology, Nephropathy, Diabetic nephropathy, Internal medicine, Diabetes mellitus, Natriuretic Peptide, Brain, Odds Ratio, medicine, Albuminuria, Humans, Diabetic Nephropathies, cardiovascular diseases, education, Aged, Macrovascular disease, Type 1 diabetes, education.field_of_study, business.industry, General Medicine, Diabetic retinopathy, Middle Aged, Brain natriuretic peptide, medicine.disease, Peptide Fragments, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Endocrinology, Female, business, Diabetic Angiopathies, hormones, hormone substitutes, and hormone antagonists
الوصف:	To evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) as a marker of long-term micro- and macrovascular complications in type 1 diabetes.This was a cross-sectional study of 208 long-term surviving type 1 diabetic patients from a population-based cohort from Fyn County, Denmark. In a clinical examination in 2007-2008, NT-proBNP was measured and related to proliferative diabetic retinopathy (PDR), nephropathy, neuropathy and macrovascular disease.Median age and duration of diabetes was 58.7 and 43 years, respectively. Median NT-proBNP concentration was 78 pg/ml (10th-90th percentile 25-653 pg/ml). The NT-proBNP level (89 vs. 71 pg/ml, p = 0.02) was higher in women. In univariate analyses, NT-proBNP was associated with age, duration of diabetes, diastolic blood pressure (inversely), nephropathy, neuropathy and macrovascular disease. For instance, median NT-proBNP concentrations were 70, 91 and 486 pg/ml for patients with normo-, micro- and macroalbuminuria, respectively (p0.01). When adjusted for age, sex, duration of diabetes, high sensitivity CRP, HbA(1c), diastolic blood pressure and smoking, higher NT-proBNP concentrations (4th vs. 1st quartile) were related to nephropathy (odds ratio [OR] 5.03; 95% confidence interval [CI] 1.77-14.25), neuropathy (OR 4.08; 95% CI 1.52-10.97) and macrovascular disease (OR 5.84; 95% CI 1.65-20.74). There was no association with PDR.NT-proBNP has traditionally been described as a marker of heart failure and left ventricular dysfunction. In this study of long-term surviving type 1 diabetic patients, we found NT-proBNP associated with nephropathy, neuropathy and macrovascular disease. If confirmed by prospective studies, NT-proBNP might be a useful prognostic marker of diabetes-related complications.
تدمد:	1502-7686 0036-5513
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c746d42c0a9c7160ea1d6997f3f523cTest https://doi.org/10.3109/00365513.2010.497869Test
حقوق:	RESTRICTED
رقم الانضمام:	edsair.doi.dedup.....6c746d42c0a9c7160ea1d6997f3f523c
قاعدة البيانات:	OpenAIRE

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patients from a population-based cohort from Fyn County, Denmark. In a clinical examination in 2007-2008, NT-proBNP was measured and related to proliferative diabetic retinopathy (PDR), nephropathy, neuropathy and macrovascular disease.Median age and duration of diabetes was 58.7 and 43 years, respectively. Median NT-proBNP concentration was 78 pg/ml (10th-90th percentile 25-653 pg/ml). The NT-proBNP level (89 vs. 71 pg/ml, p = 0.02) was higher in women. In univariate analyses, NT-proBNP was associated with age, duration of diabetes, diastolic blood pressure (inversely), nephropathy, neuropathy and macrovascular disease. For instance, median NT-proBNP concentrations were 70, 91 and 486 pg/ml for patients with normo-, micro- and macroalbuminuria, respectively (p0.01). When adjusted for age, sex, duration of diabetes, high sensitivity CRP, HbA(1c), diastolic blood pressure and smoking, higher NT-proBNP concentrations (4th vs. 1st quartile) were related to nephropathy (odds ratio [OR] 5.03; 95% confidence interval [CI] 1.77-14.25), neuropathy (OR 4.08; 95% CI 1.52-10.97) and macrovascular disease (OR 5.84; 95% CI 1.65-20.74). There was no association with PDR.NT-proBNP has traditionally been described as a marker of heart failure and left ventricular dysfunction. In this study of long-term surviving type 1 diabetic patients, we found NT-proBNP associated with nephropathy, neuropathy and macrovascular disease. 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