d -Glucose-Derived 1,2,4-Trioxepanes: Synthesis, Conformational Study, and Antimalarial Activity
| العنوان: | |
|---|---|
| المؤلفون: | Yolanda Corbett, Claudio Trombini, Arianna Quintavalla, Dilip D. Dhavale, Marco Lombardo, Donatella Taramelli, Dhiraj P. Sonawane |
| المساهمون: | Sonawane, D P, Corbett, Y, Dhavale, D D, Taramelli, D, Trombini, C, Quintavalla, A, Lombardo, M |
| المصدر: | Organic Letters. 17:4074-4077 |
| بيانات النشر: | American Chemical Society (ACS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Stereochemistry, Plasmodium falciparum, Molecular Conformation, Adamantane, Biochemistry, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, D-Glucose, Trioxepanes, Antimalarials, Glucose, Synthesis, Conformational study, Ic50 values, Physical and Theoretical Chemistry, IC50, Dose-Response Relationship, Drug, Molecular Structure, biology, Strain (chemistry), Chemistry, Organic Chemistry, Chloroquine, Stereoisomerism, biology.organism_classification, In vitro, Glucose, Oxepins, Derivative (chemistry) |
| الوصف: | New enantiomerically pure 1,2,4-trioxepanes 10a,b/11a,b were synthesized from d-glucose. Their conformational behavior was studied by low-temperature NMR and substantiated by DFT calculations. On evaluation of in vitro antimalarial activity, the adamantyl derivative 11b showed IC50 values in the low micromolar range, particularly against the W2 chloroquine-resistant Plasmodium falciparum strain (IC50 = 0.15 ± 0.12 μM). |
| وصف الملف: | STAMPA |
| تدمد: | 1523-7052 1523-7060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b08f71afec5c220dbe440baa7d1845aTest https://doi.org/10.1021/acs.orglett.5b01996Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6b08f71afec5c220dbe440baa7d1845a |
| قاعدة البيانات: | OpenAIRE |
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