Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management
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[Data] => Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management
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Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Hai-Yong+Chen%22">Hai-Yong Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Yibin+Feng%22">Yibin Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng+Zhang%22">Cheng Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Ning+Wang%22">Ning Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Sha+Li%22">Sha Li</searchLink><br /><searchLink fieldCode="AR" term="%22Guoyi+Tang%22">Guoyi Tang</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Acta Pharmaceutica Sinica. B<br />Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier BV, 2021. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22LOX1%2C+lectin-like+oxidized+LDL+receptor+1%22">LOX1, lectin-like oxidized LDL receptor 1</searchLink><br /><searchLink fieldCode="DE" term="%22BUN%2C+blood+urea+nitrogen%22">BUN, blood urea nitrogen</searchLink><br /><searchLink fieldCode="DE" term="%22TGBM%2C+thickness+of+glomerular+basement+membrane%22">TGBM, thickness of glomerular basement membrane</searchLink><br /><searchLink fieldCode="DE" term="%22NQO1%2C+NAD%28P%29H%3Aquinone+oxidoreductase+1%22">NQO1, NAD(P)H:quinone oxidoreductase 1</searchLink><br /><searchLink fieldCode="DE" term="%22STAT%2C+signal+transducers+and+activators+of+transcription%22">STAT, signal transducers and activators of transcription</searchLink><br /><searchLink fieldCode="DE" term="%22N%2FO%2C+not+observed%22">N/O, not observed</searchLink><br /><searchLink fieldCode="DE" term="%22p62%2C+sequestosome+1+protein%22">p62, sequestosome 1 protein</searchLink><br /><searchLink fieldCode="DE" term="%22p-IRS1%2C+phospho-IRS1%22">p-IRS1, phospho-IRS1</searchLink><br /><searchLink fieldCode="DE" term="%22Review%22">Review</searchLink><br /><searchLink fieldCode="DE" term="%22NOX-4%2C+nicotinamide+adenine+dinucleotide+phosphate-oxidase-4%22">NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4</searchLink><br /><searchLink fieldCode="DE" term="%22OCP%2C+oxidative+carbonyl+protein%22">OCP, oxidative carbonyl protein</searchLink><br /><searchLink fieldCode="DE" term="%22Traditional+Chinese+medicine%22">Traditional Chinese medicine</searchLink><br /><searchLink fieldCode="DE" term="%22AGEs%2C+advanced+glycation+end-products%22">AGEs, advanced glycation end-products</searchLink><br /><searchLink fieldCode="DE" term="%22N%2FA%2C+not+applicable%22">N/A, not applicable</searchLink><br /><searchLink fieldCode="DE" term="%22TRAF5%2C+tumor-necrosis+factor+receptor-associated+factor+5%22">TRAF5, tumor-necrosis factor receptor-associated factor 5</searchLink><br /><searchLink fieldCode="DE" term="%22Health+problems%22">Health problems</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22ESRD%2C+end-stage+renal+disease%22">ESRD, end-stage renal disease</searchLink><br /><searchLink fieldCode="DE" term="%22LDL%2C+low-density+lipoprotein%22">LDL, low-density lipoprotein</searchLink><br /><searchLink fieldCode="DE" term="%22BMP-7%2C+bone+morphogenetic+protein-7%22">BMP-7, bone morphogenetic protein-7</searchLink><br /><searchLink fieldCode="DE" 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term="%22BW%2C+body+weight%22">BW, body weight</searchLink><br /><searchLink fieldCode="DE" term="%22HDL-C%2C+high+density+lipoprotein-cholesterol%22">HDL-C, high density lipoprotein-cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22RASI%2C+renin-angiotensin+system+inhibitor%22">RASI, renin-angiotensin system inhibitor</searchLink><br /><searchLink fieldCode="DE" term="%22ATK%2C+protein+kinase+B%22">ATK, protein kinase B</searchLink><br /><searchLink fieldCode="DE" term="%22TBARS%2C+thiobarbituric+acid-reactive+substance%22">TBARS, thiobarbituric acid-reactive substance</searchLink><br /><searchLink fieldCode="DE" term="%22BCL-XL%2C+B-cell+lymphoma-extra+large%22">BCL-XL, B-cell lymphoma-extra large</searchLink><br /><searchLink fieldCode="DE" term="%22Gαq%2C+Gq+protein+alpha+subunit%22">Gαq, Gq protein alpha subunit</searchLink><br /><searchLink fieldCode="DE" term="%22GCK%2C+glucokinase%22">GCK, glucokinase</searchLink><br /><searchLink fieldCode="DE" term="%22PI3K%2C+phosphatidylinositol+3+kinases%22">PI3K, phosphatidylinositol 3 kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+review%22">Systematic review</searchLink><br /><searchLink fieldCode="DE" term="%22TLR-2%2F4%2C+toll-like+receptor+2%2F4%22">TLR-2/4, toll-like receptor 2/4</searchLink><br /><searchLink fieldCode="DE" term="%22IR%2C+insulin+receptor%22">IR, insulin receptor</searchLink><br /><searchLink fieldCode="DE" term="%22PERK%2C+protein+kinase+RNA-like+eukaryotic+initiation+factor+2A+kinase%22">PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase</searchLink><br /><searchLink fieldCode="DE" term="%22030220+oncology+%26+carcinogenesis%22">030220 oncology & carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22CRP%2C+C-reactive+protein%22">CRP, C-reactive protein</searchLink><br /><searchLink fieldCode="DE" term="%22IRS%2C+insulin+receptor+substrate%22">IRS, insulin receptor substrate</searchLink><br /><searchLink fieldCode="DE" term="%22AM%2C+mesangial+area%22">AM, mesangial area</searchLink><br /><searchLink fieldCode="DE" term="%22JAK%2C+Janus+kinase%22">JAK, Janus kinase</searchLink><br /><searchLink fieldCode="DE" term="%22FBG%2C+fasting+blood+glucose%22">FBG, fasting blood glucose</searchLink><br /><searchLink fieldCode="DE" term="%22ETAR%2C+endothelium+A+receptor%22">ETAR, endothelium A receptor</searchLink><br /><searchLink fieldCode="DE" term="%22LDL-C%2C+low+density+lipoprotein-cholesterol%22">LDL-C, low density lipoprotein-cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22CD2AP%2C+CD2-associated+protein%22">CD2AP, CD2-associated protein</searchLink><br /><searchLink fieldCode="DE" term="%22eIF2α%2C+eukaryotic+initiation+factor+2α%22">eIF2α, eukaryotic initiation factor 2α</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink><br /><searchLink fieldCode="DE" term="%22mTOR%2C+mammalian+target+of+rapamycin%22">mTOR, mammalian target of rapamycin</searchLink><br /><searchLink fieldCode="DE" term="%22CHOP%2C+C%2FEBP+homologous+protein%22">CHOP, C/EBP homologous protein</searchLink><br /><searchLink fieldCode="DE" term="%22STZ%2C+streptozotocin%22">STZ, streptozotocin</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22ADE%2C+adverse+event%22">ADE, adverse event</searchLink><br /><searchLink fieldCode="DE" term="%22PKC%2C+protein+kinase+C%22">PKC, protein kinase C</searchLink><br /><searchLink fieldCode="DE" term="%22LC3%2C+microtubule-associated+protein+light+chain+3%22">LC3, microtubule-associated protein light chain 3</searchLink><br /><searchLink fieldCode="DE" term="%22ORP150%2C+150-kDa+oxygen-regulated+protein%22">ORP150, 150-kDa oxygen-regulated protein</searchLink><br /><searchLink fieldCode="DE" term="%22PGE2%2C+prostaglandin+E2%22">PGE2, prostaglandin E2</searchLink><br /><searchLink fieldCode="DE" term="%22IL-1β%2F6%2C+interleukin+1β%2F6%22">IL-1β/6, interleukin 1β/6</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetic+kidney+disease%22">Diabetic kidney disease</searchLink><br /><searchLink fieldCode="DE" term="%22IGF-1%2C+insulin-like+growth+factor+1%22">IGF-1, insulin-like growth factor 1</searchLink><br /><searchLink fieldCode="DE" term="%22EP%2C+E-prostanoid+receptor%22">EP, E-prostanoid receptor</searchLink><br /><searchLink fieldCode="DE" term="%22FN%2C+fibronectin%22">FN, fibronectin</searchLink><br /><searchLink fieldCode="DE" term="%22eGFR%2C+estimated+GFR%22">eGFR, estimated GFR</searchLink><br /><searchLink fieldCode="DE" term="%22MDA%2C+malondialdehyde%22">MDA, malondialdehyde</searchLink><br /><searchLink fieldCode="DE" term="%22Chinese+medicine%22">Chinese medicine</searchLink><br /><searchLink fieldCode="DE" term="%22MMP-2%2C+matrix+metallopeptidase+2%22">MMP-2, matrix metallopeptidase 2</searchLink><br /><searchLink fieldCode="DE" term="%22XBP-1%2C+spliced+X+box-binding+protein+1%22">XBP-1, spliced X box-binding protein 1</searchLink><br /><searchLink fieldCode="DE" term="%22TGF-β%2C+tumor+growth+factor+β%22">TGF-β, tumor growth factor β</searchLink><br /><searchLink fieldCode="DE" term="%22GRB+10%2C+growth+factor+receptor-bound+protein+10%22">GRB 10, growth factor receptor-bound protein 10</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trial%22">Clinical trial</searchLink><br /><searchLink fieldCode="DE" term="%22GRP78%2C+glucose-regulated+protein+78%22">GRP78, glucose-regulated protein 78</searchLink><br /><searchLink fieldCode="DE" term="%22UP%2C+urinary+protein%22">UP, urinary protein</searchLink><br /><searchLink fieldCode="DE" term="%22IGF-1R%2C+insulin-like+growth+factor+1+receptor%22">IGF-1R, insulin-like growth factor 1 receptor</searchLink><br /><searchLink fieldCode="DE" term="%22ACEI%2C+angiotensin-converting+enzyme+inhibitor%22">ACEI, angiotensin-converting enzyme inhibitor</searchLink><br /><searchLink fieldCode="DE" term="%22BCL-2%2C+B-cell+lymphoma+2%22">BCL-2, B-cell lymphoma 2</searchLink><br /><searchLink fieldCode="DE" term="%22EMT%2C+epithelial-to-mesenchymal+transition%22">EMT, epithelial-to-mesenchymal transition</searchLink><br /><searchLink fieldCode="DE" term="%22MAPK%2C+mitogen-activated+protein+kinase%22">MAPK, mitogen-activated protein kinase</searchLink><br /><searchLink fieldCode="DE" term="%22MYD88%2C+myeloid+differentiation+primary+response+88%22">MYD88, myeloid differentiation primary response 88</searchLink><br /><searchLink fieldCode="DE" term="%22PBG%2C+postprandial+blood+glucose%22">PBG, postprandial blood glucose</searchLink><br /><searchLink fieldCode="DE" term="%22RCT%2C+randomized+clinical+trial%22">RCT, randomized clinical trial</searchLink><br /><searchLink fieldCode="DE" term="%22N%2FR%2C+not+reported%22">N/R, not reported</searchLink><br /><searchLink fieldCode="DE" term="%22COL-I%2FIV%2C+collagen+I%2FIV%22">COL-I/IV, collagen I/IV</searchLink><br /><searchLink fieldCode="DE" term="%22PINK1%2C+PTEN-induced+putative+kinase+1%22">PINK1, PTEN-induced putative kinase 1</searchLink><br /><searchLink fieldCode="DE" term="%22UACR%2C+urinary+albumin+to+creatinine+ratio%22">UACR, urinary albumin to creatinine ratio</searchLink><br /><searchLink fieldCode="DE" term="%22C%2C+control+group%22">C, control group</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetic+nephropathy%22">Diabetic nephropathy</searchLink><br /><searchLink fieldCode="DE" term="%22GPX%2C+glutathione+peroxidase%22">GPX, glutathione peroxidase</searchLink><br /><searchLink fieldCode="DE" term="%22ICAM-1%2C+intercellular+adhesion+molecule-1%22">ICAM-1, intercellular adhesion molecule-1</searchLink><br /><searchLink fieldCode="DE" term="%22Bioinformatics%22">Bioinformatics</searchLink><br /><searchLink fieldCode="DE" term="%22VCAM-1%2C+vascular+cell+adhesion+molecule-1%22">VCAM-1, vascular cell adhesion molecule-1</searchLink><br /><searchLink fieldCode="DE" term="%22AMPKα%2C+adenosine+monophosphate-activated+protein+kinase+α%22">AMPKα, adenosine monophosphate-activated protein kinase α</searchLink><br /><searchLink fieldCode="DE" term="%22DM%2C+diabetes+mellitus%22">DM, diabetes mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22TFEB%2C+transcription+factor+EB%22">TFEB, transcription factor EB</searchLink><br /><searchLink fieldCode="DE" term="%22TNF-α%2C+tumor+necrosis+factor+α%22">TNF-α, tumor necrosis factor α</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+target%22">Molecular target</searchLink><br /><searchLink fieldCode="DE" term="%22IKK-β%2C+IκB+kinase+β%22">IKK-β, IκB kinase β</searchLink><br /><searchLink fieldCode="DE" term="%22Signaling+pathway%22">Signaling pathway</searchLink><br /><searchLink fieldCode="DE" term="%22GLUT4%2C+glucose+transporter+type+4%22">GLUT4, glucose transporter type 4</searchLink><br /><searchLink fieldCode="DE" term="%22BAX%2C+BCL-2-associated+X+protein%22">BAX, BCL-2-associated X protein</searchLink><br /><searchLink fieldCode="DE" term="%22NF-κB%2C+nuclear+factor+kappa-light-chain-enhancer+of+activated+B+cells%22">NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells</searchLink><br /><searchLink fieldCode="DE" term="%22PARP%2C+poly%28ADP-Ribose%29+polymerase%22">PARP, poly(ADP-Ribose) polymerase</searchLink><br /><searchLink fieldCode="DE" term="%22SMURF-2%2C+SMAD+ubiquitination+regulatory+factor+2%22">SMURF-2, SMAD ubiquitination regulatory factor 2</searchLink><br /><searchLink fieldCode="DE" term="%22AREs%2C+antioxidant+response+elements%22">AREs, antioxidant response elements</searchLink><br /><searchLink fieldCode="DE" term="%22MD%2C+mean+difference%22">MD, mean difference</searchLink><br /><searchLink fieldCode="DE" term="%22SMAD%2C+small+mothers+against+decapentaplegic%22">SMAD, small mothers against decapentaplegic</searchLink><br /><searchLink fieldCode="DE" term="%22MCP-1%2C+monocyte+chemotactic+protein-1%22">MCP-1, monocyte chemotactic protein-1</searchLink><br /><searchLink fieldCode="DE" term="%22VEGF%2C+vascular+endothelial+growth+factor%22">VEGF, vascular endothelial growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22cAMP%2C+cyclic+adenosine+monophosphate%22">cAMP, cyclic adenosine monophosphate</searchLink><br /><searchLink fieldCode="DE" term="%22ARB%2C+angiotensin+receptor+blocker%22">ARB, angiotensin receptor blocker</searchLink><br /><searchLink fieldCode="DE" term="%22PAI-1%2C+plasminogen+activator+inhibitor-1%22">PAI-1, plasminogen activator inhibitor-1</searchLink><br /><searchLink fieldCode="DE" term="%22SMD%2C+standard+mean+difference%22">SMD, standard mean difference</searchLink><br /><searchLink fieldCode="DE" term="%22JNK%2C+c-Jun+N-terminal+kinase%22">JNK, c-Jun N-terminal kinase</searchLink><br /><searchLink fieldCode="DE" term="%22NRF2%2C+nuclear+factor+erythroid+2-related+factor+2%22">NRF2, nuclear factor erythroid 2-related factor 2</searchLink><br /><searchLink fieldCode="DE" term="%22IκB-α%2C+inhibitory+protein+α%22">IκB-α, inhibitory protein α</searchLink><br /><searchLink fieldCode="DE" term="%22Herbal+medicine%22">Herbal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22TCM%2C+traditional+Chinese+medicine%22">TCM, traditional Chinese medicine</searchLink><br /><searchLink fieldCode="DE" term="%22DG%2C+glomerular+diameter%22">DG, glomerular diameter</searchLink><br /><searchLink fieldCode="DE" term="%22GSK-3%2C+glycogen+synthase+kinase+3%22">GSK-3, glycogen synthase kinase 3</searchLink><br /><searchLink fieldCode="DE" term="%22SIRT1%2C+sirtuin+1%22">SIRT1, sirtuin 1</searchLink><br /><searchLink fieldCode="DE" term="%22D%2C+duration%22">D, duration</searchLink><br /><searchLink fieldCode="DE" term="%22HbA1c%2C+glycosylated+hemoglobin%22">HbA1c, glycosylated hemoglobin</searchLink><br /><searchLink fieldCode="DE" term="%22WMD%2C+weight+mean+difference%22">WMD, weight mean difference</searchLink><br /><searchLink fieldCode="DE" term="%22CTGF%2C+connective+tissue+growth+factor%22">CTGF, connective tissue growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22ER%2C+endoplasmic+reticulum%22">ER, endoplasmic reticulum</searchLink><br /><searchLink fieldCode="DE" term="%22DN%2C+diabetic+nephropathy%22">DN, diabetic nephropathy</searchLink><br /><searchLink fieldCode="DE" term="%22ROS%2C+reactive+oxygen+species%22">ROS, reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22CCR%2C+creatinine+clearance+rate%22">CCR, creatinine clearance rate</searchLink><br /><searchLink fieldCode="DE" term="%22SOD%2C+superoxide+dismutase%22">SOD, superoxide dismutase</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+mellitus%22">Diabetes mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22PGC-1α%2C+peroxisome+proliferator-activated+receptor+gamma+coactivator+1α%22">PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α</searchLink><br /><searchLink fieldCode="DE" term="%22ET-1%2C+endothelin-1%22">ET-1, endothelin-1</searchLink><br /><searchLink fieldCode="DE" term="%22UMA%2C+urinary+microalbumin%22">UMA, urinary microalbumin</searchLink><br /><searchLink fieldCode="DE" term="%22SCr%2C+serum+creatinine%22">SCr, serum creatinine</searchLink><br /><searchLink fieldCode="DE" term="%22IRE-1α%2C+inositol-requiring+enzyme-1α%22">IRE-1α, inositol-requiring enzyme-1α</searchLink><br /><searchLink fieldCode="DE" term="%22030304+developmental+biology%22">030304 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22TII%2C+tubulointerstitial+injury+index%22">TII, tubulointerstitial injury index</searchLink><br /><searchLink fieldCode="DE" term="%22RAGE%2C+receptors+of+AGE%22">RAGE, receptors of AGE</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22GFR%2C+glomerular+filtration+rate%22">GFR, glomerular filtration rate</searchLink><br /><searchLink fieldCode="DE" term="%22PTEN%2C+phosphatase+and+tensin+homolog%22">PTEN, phosphatase and tensin homolog</searchLink><br /><searchLink fieldCode="DE" term="%22CI%2C+confidence+interval%22">CI, confidence interval</searchLink><br /><searchLink fieldCode="DE" term="%22TC%2C+total+cholesterol%22">TC, total cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22SD-rat%2C+Sprague–Dawley+rat%22">SD-rat, Sprague–Dawley rat</searchLink><br /><searchLink fieldCode="DE" term="%22UAER%2C+urinary+albumin+excretion+rate%22">UAER, urinary albumin excretion rate</searchLink><br /><searchLink fieldCode="DE" term="%22DKD%2C+diabetic+kidney+disease%22">DKD, diabetic kidney disease</searchLink><br /><searchLink fieldCode="DE" term="%22T%2C+treatment+group%22">T, treatment group</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+targets%22">Molecular targets</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22α-SMA%2C+α+smooth+muscle+actin%22">α-SMA, α smooth muscle actin</searchLink><br /><searchLink fieldCode="DE" term="%22SD%2C+standard+deviation%22">SD, standard deviation</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22DAG%2C+diacylglycerol%22">DAG, diacylglycerol</searchLink><br /><searchLink fieldCode="DE" term="%22GCLC%2C+glutamate-cysteine+ligase+catalytic+subunit%22">GCLC, glutamate-cysteine ligase catalytic subunit</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+disease%22">Kidney disease</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional strategies, such as renin-angiotensin-aldosterone system blockade, blood glucose level control, and bodyweight reduction, may not achieve satisfactory outcomes in many clinical practices for DN management. Notably, due to the multi-target function, Chinese medicine possesses promising clinical benefits as primary or alternative therapies for DN treatment. Increasing studies have emphasized identifying bioactive compounds and molecular mechanisms of reno-protective effects of Chinese medicines. Signaling pathways involved in glucose/lipid metabolism regulation, antioxidation, anti-inflammation, anti-fibrosis, and podocyte protection have been identified as crucial mechanisms of action. Herein, we summarize the clinical efficacies of Chinese medicines and their bioactive components in treating and managing DN after reviewing the results demonstrated in clinical trials, systematic reviews, and meta-analyses, with a thorough discussion on the relative underlying mechanisms and molecular targets reported in animal and cellular experiments. We aim to provide comprehensive insights into the protective effects of Chinese medicines against DN.<br />Graphical abstract Diabetic nephropathy is one of the most severe complications of diabetes mellitus. Chinese medicines have been intensively studied in treating diabetic nephropathy. This review comprehensively summarizes and discusses the clinical efficacies and underlying mechanisms of Chinese medicines for diabetic nephropathy, providing deep insights and profound perspectives into this field.Image 1 ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2211-3835 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1016/j.apsb.2020.12.020" linkWindow="_blank">https://doi.org/10.1016/j.apsb.2020.12.020</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....68d8ab4193adc39b242fa3c089b4f517 ) |
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[SubjectFull] => LOX1, lectin-like oxidized LDL receptor 1
[Type] => general
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[1] => Array
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[SubjectFull] => BUN, blood urea nitrogen
[Type] => general
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[2] => Array
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[SubjectFull] => TGBM, thickness of glomerular basement membrane
[Type] => general
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[3] => Array
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[SubjectFull] => NQO1, NAD(P)H:quinone oxidoreductase 1
[Type] => general
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[4] => Array
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[SubjectFull] => STAT, signal transducers and activators of transcription
[Type] => general
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[5] => Array
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[SubjectFull] => N/O, not observed
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[SubjectFull] => p62, sequestosome 1 protein
[Type] => general
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(
[SubjectFull] => p-IRS1, phospho-IRS1
[Type] => general
)
[8] => Array
(
[SubjectFull] => Review
[Type] => general
)
[9] => Array
(
[SubjectFull] => NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4
[Type] => general
)
[10] => Array
(
[SubjectFull] => OCP, oxidative carbonyl protein
[Type] => general
)
[11] => Array
(
[SubjectFull] => Traditional Chinese medicine
[Type] => general
)
[12] => Array
(
[SubjectFull] => AGEs, advanced glycation end-products
[Type] => general
)
[13] => Array
(
[SubjectFull] => N/A, not applicable
[Type] => general
)
[14] => Array
(
[SubjectFull] => TRAF5, tumor-necrosis factor receptor-associated factor 5
[Type] => general
)
[15] => Array
(
[SubjectFull] => Health problems
[Type] => general
)
[16] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[17] => Array
(
[SubjectFull] => ESRD, end-stage renal disease
[Type] => general
)
[18] => Array
(
[SubjectFull] => LDL, low-density lipoprotein
[Type] => general
)
[19] => Array
(
[SubjectFull] => BMP-7, bone morphogenetic protein-7
[Type] => general
)
[20] => Array
(
[SubjectFull] => TGFβR-I/II, TGF-β receptor I/II
[Type] => general
)
[21] => Array
(
[SubjectFull] => Medicine
[Type] => general
)
[22] => Array
(
[SubjectFull] => P70S6K, 70-kDa ribosomal protein S6 kinase
[Type] => general
)
[23] => Array
(
[SubjectFull] => General Pharmacology, Toxicology and Pharmaceutics
[Type] => general
)
[24] => Array
(
[SubjectFull] => SOCS, suppressor of cytokine signaling proteins
[Type] => general
)
[25] => Array
(
[SubjectFull] => HO-1, heme oxygenase-1
[Type] => general
)
[26] => Array
(
[SubjectFull] => 0303 health sciences
[Type] => general
)
[27] => Array
(
[SubjectFull] => TG, triglyceride
[Type] => general
)
[28] => Array
(
[SubjectFull] => BW, body weight
[Type] => general
)
[29] => Array
(
[SubjectFull] => HDL-C, high density lipoprotein-cholesterol
[Type] => general
)
[30] => Array
(
[SubjectFull] => RASI, renin-angiotensin system inhibitor
[Type] => general
)
[31] => Array
(
[SubjectFull] => ATK, protein kinase B
[Type] => general
)
[32] => Array
(
[SubjectFull] => TBARS, thiobarbituric acid-reactive substance
[Type] => general
)
[33] => Array
(
[SubjectFull] => BCL-XL, B-cell lymphoma-extra large
[Type] => general
)
[34] => Array
(
[SubjectFull] => Gαq, Gq protein alpha subunit
[Type] => general
)
[35] => Array
(
[SubjectFull] => GCK, glucokinase
[Type] => general
)
[36] => Array
(
[SubjectFull] => PI3K, phosphatidylinositol 3 kinases
[Type] => general
)
[37] => Array
(
[SubjectFull] => Systematic review
[Type] => general
)
[38] => Array
(
[SubjectFull] => TLR-2/4, toll-like receptor 2/4
[Type] => general
)
[39] => Array
(
[SubjectFull] => IR, insulin receptor
[Type] => general
)
[40] => Array
(
[SubjectFull] => PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase
[Type] => general
)
[41] => Array
(
[SubjectFull] => 030220 oncology & carcinogenesis
[Type] => general
)
[42] => Array
(
[SubjectFull] => CRP, C-reactive protein
[Type] => general
)
[43] => Array
(
[SubjectFull] => IRS, insulin receptor substrate
[Type] => general
)
[44] => Array
(
[SubjectFull] => AM, mesangial area
[Type] => general
)
[45] => Array
(
[SubjectFull] => JAK, Janus kinase
[Type] => general
)
[46] => Array
(
[SubjectFull] => FBG, fasting blood glucose
[Type] => general
)
[47] => Array
(
[SubjectFull] => ETAR, endothelium A receptor
[Type] => general
)
[48] => Array
(
[SubjectFull] => LDL-C, low density lipoprotein-cholesterol
[Type] => general
)
[49] => Array
(
[SubjectFull] => CD2AP, CD2-associated protein
[Type] => general
)
[50] => Array
(
[SubjectFull] => eIF2α, eukaryotic initiation factor 2α
[Type] => general
)
[51] => Array
(
[SubjectFull] => RM1-950
[Type] => general
)
[52] => Array
(
[SubjectFull] => mTOR, mammalian target of rapamycin
[Type] => general
)
[53] => Array
(
[SubjectFull] => CHOP, C/EBP homologous protein
[Type] => general
)
[54] => Array
(
[SubjectFull] => STZ, streptozotocin
[Type] => general
)
[55] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[56] => Array
(
[SubjectFull] => ADE, adverse event
[Type] => general
)
[57] => Array
(
[SubjectFull] => PKC, protein kinase C
[Type] => general
)
[58] => Array
(
[SubjectFull] => LC3, microtubule-associated protein light chain 3
[Type] => general
)
[59] => Array
(
[SubjectFull] => ORP150, 150-kDa oxygen-regulated protein
[Type] => general
)
[60] => Array
(
[SubjectFull] => PGE2, prostaglandin E2
[Type] => general
)
[61] => Array
(
[SubjectFull] => IL-1β/6, interleukin 1β/6
[Type] => general
)
[62] => Array
(
[SubjectFull] => Diabetic kidney disease
[Type] => general
)
[63] => Array
(
[SubjectFull] => IGF-1, insulin-like growth factor 1
[Type] => general
)
[64] => Array
(
[SubjectFull] => EP, E-prostanoid receptor
[Type] => general
)
[65] => Array
(
[SubjectFull] => FN, fibronectin
[Type] => general
)
[66] => Array
(
[SubjectFull] => eGFR, estimated GFR
[Type] => general
)
[67] => Array
(
[SubjectFull] => MDA, malondialdehyde
[Type] => general
)
[68] => Array
(
[SubjectFull] => Chinese medicine
[Type] => general
)
[69] => Array
(
[SubjectFull] => MMP-2, matrix metallopeptidase 2
[Type] => general
)
[70] => Array
(
[SubjectFull] => XBP-1, spliced X box-binding protein 1
[Type] => general
)
[71] => Array
(
[SubjectFull] => TGF-β, tumor growth factor β
[Type] => general
)
[72] => Array
(
[SubjectFull] => GRB 10, growth factor receptor-bound protein 10
[Type] => general
)
[73] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[74] => Array
(
[SubjectFull] => Clinical trial
[Type] => general
)
[75] => Array
(
[SubjectFull] => GRP78, glucose-regulated protein 78
[Type] => general
)
[76] => Array
(
[SubjectFull] => UP, urinary protein
[Type] => general
)
[77] => Array
(
[SubjectFull] => IGF-1R, insulin-like growth factor 1 receptor
[Type] => general
)
[78] => Array
(
[SubjectFull] => ACEI, angiotensin-converting enzyme inhibitor
[Type] => general
)
[79] => Array
(
[SubjectFull] => BCL-2, B-cell lymphoma 2
[Type] => general
)
[80] => Array
(
[SubjectFull] => EMT, epithelial-to-mesenchymal transition
[Type] => general
)
[81] => Array
(
[SubjectFull] => MAPK, mitogen-activated protein kinase
[Type] => general
)
[82] => Array
(
[SubjectFull] => MYD88, myeloid differentiation primary response 88
[Type] => general
)
[83] => Array
(
[SubjectFull] => PBG, postprandial blood glucose
[Type] => general
)
[84] => Array
(
[SubjectFull] => RCT, randomized clinical trial
[Type] => general
)
[85] => Array
(
[SubjectFull] => N/R, not reported
[Type] => general
)
[86] => Array
(
[SubjectFull] => COL-I/IV, collagen I/IV
[Type] => general
)
[87] => Array
(
[SubjectFull] => PINK1, PTEN-induced putative kinase 1
[Type] => general
)
[88] => Array
(
[SubjectFull] => UACR, urinary albumin to creatinine ratio
[Type] => general
)
[89] => Array
(
[SubjectFull] => C, control group
[Type] => general
)
[90] => Array
(
[SubjectFull] => Diabetic nephropathy
[Type] => general
)
[91] => Array
(
[SubjectFull] => GPX, glutathione peroxidase
[Type] => general
)
[92] => Array
(
[SubjectFull] => ICAM-1, intercellular adhesion molecule-1
[Type] => general
)
[93] => Array
(
[SubjectFull] => Bioinformatics
[Type] => general
)
[94] => Array
(
[SubjectFull] => VCAM-1, vascular cell adhesion molecule-1
[Type] => general
)
[95] => Array
(
[SubjectFull] => AMPKα, adenosine monophosphate-activated protein kinase α
[Type] => general
)
[96] => Array
(
[SubjectFull] => DM, diabetes mellitus
[Type] => general
)
[97] => Array
(
[SubjectFull] => TFEB, transcription factor EB
[Type] => general
)
[98] => Array
(
[SubjectFull] => TNF-α, tumor necrosis factor α
[Type] => general
)
[99] => Array
(
[SubjectFull] => Molecular target
[Type] => general
)
[100] => Array
(
[SubjectFull] => IKK-β, IκB kinase β
[Type] => general
)
[101] => Array
(
[SubjectFull] => Signaling pathway
[Type] => general
)
[102] => Array
(
[SubjectFull] => GLUT4, glucose transporter type 4
[Type] => general
)
[103] => Array
(
[SubjectFull] => BAX, BCL-2-associated X protein
[Type] => general
)
[104] => Array
(
[SubjectFull] => NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells
[Type] => general
)
[105] => Array
(
[SubjectFull] => PARP, poly(ADP-Ribose) polymerase
[Type] => general
)
[106] => Array
(
[SubjectFull] => SMURF-2, SMAD ubiquitination regulatory factor 2
[Type] => general
)
[107] => Array
(
[SubjectFull] => AREs, antioxidant response elements
[Type] => general
)
[108] => Array
(
[SubjectFull] => MD, mean difference
[Type] => general
)
[109] => Array
(
[SubjectFull] => SMAD, small mothers against decapentaplegic
[Type] => general
)
[110] => Array
(
[SubjectFull] => MCP-1, monocyte chemotactic protein-1
[Type] => general
)
[111] => Array
(
[SubjectFull] => VEGF, vascular endothelial growth factor
[Type] => general
)
[112] => Array
(
[SubjectFull] => cAMP, cyclic adenosine monophosphate
[Type] => general
)
[113] => Array
(
[SubjectFull] => ARB, angiotensin receptor blocker
[Type] => general
)
[114] => Array
(
[SubjectFull] => PAI-1, plasminogen activator inhibitor-1
[Type] => general
)
[115] => Array
(
[SubjectFull] => SMD, standard mean difference
[Type] => general
)
[116] => Array
(
[SubjectFull] => JNK, c-Jun N-terminal kinase
[Type] => general
)
[117] => Array
(
[SubjectFull] => NRF2, nuclear factor erythroid 2-related factor 2
[Type] => general
)
[118] => Array
(
[SubjectFull] => IκB-α, inhibitory protein α
[Type] => general
)
[119] => Array
(
[SubjectFull] => Herbal medicine
[Type] => general
)
[120] => Array
(
[SubjectFull] => TCM, traditional Chinese medicine
[Type] => general
)
[121] => Array
(
[SubjectFull] => DG, glomerular diameter
[Type] => general
)
[122] => Array
(
[SubjectFull] => GSK-3, glycogen synthase kinase 3
[Type] => general
)
[123] => Array
(
[SubjectFull] => SIRT1, sirtuin 1
[Type] => general
)
[124] => Array
(
[SubjectFull] => D, duration
[Type] => general
)
[125] => Array
(
[SubjectFull] => HbA1c, glycosylated hemoglobin
[Type] => general
)
[126] => Array
(
[SubjectFull] => WMD, weight mean difference
[Type] => general
)
[127] => Array
(
[SubjectFull] => CTGF, connective tissue growth factor
[Type] => general
)
[128] => Array
(
[SubjectFull] => ER, endoplasmic reticulum
[Type] => general
)
[129] => Array
(
[SubjectFull] => DN, diabetic nephropathy
[Type] => general
)
[130] => Array
(
[SubjectFull] => ROS, reactive oxygen species
[Type] => general
)
[131] => Array
(
[SubjectFull] => CCR, creatinine clearance rate
[Type] => general
)
[132] => Array
(
[SubjectFull] => SOD, superoxide dismutase
[Type] => general
)
[133] => Array
(
[SubjectFull] => Diabetes mellitus
[Type] => general
)
[134] => Array
(
[SubjectFull] => PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α
[Type] => general
)
[135] => Array
(
[SubjectFull] => ET-1, endothelin-1
[Type] => general
)
[136] => Array
(
[SubjectFull] => UMA, urinary microalbumin
[Type] => general
)
[137] => Array
(
[SubjectFull] => SCr, serum creatinine
[Type] => general
)
[138] => Array
(
[SubjectFull] => IRE-1α, inositol-requiring enzyme-1α
[Type] => general
)
[139] => Array
(
[SubjectFull] => 030304 developmental biology
[Type] => general
)
[140] => Array
(
[SubjectFull] => TII, tubulointerstitial injury index
[Type] => general
)
[141] => Array
(
[SubjectFull] => RAGE, receptors of AGE
[Type] => general
)
[142] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[143] => Array
(
[SubjectFull] => GFR, glomerular filtration rate
[Type] => general
)
[144] => Array
(
[SubjectFull] => PTEN, phosphatase and tensin homolog
[Type] => general
)
[145] => Array
(
[SubjectFull] => CI, confidence interval
[Type] => general
)
[146] => Array
(
[SubjectFull] => TC, total cholesterol
[Type] => general
)
[147] => Array
(
[SubjectFull] => SD-rat, Sprague–Dawley rat
[Type] => general
)
[148] => Array
(
[SubjectFull] => UAER, urinary albumin excretion rate
[Type] => general
)
[149] => Array
(
[SubjectFull] => DKD, diabetic kidney disease
[Type] => general
)
[150] => Array
(
[SubjectFull] => T, treatment group
[Type] => general
)
[151] => Array
(
[SubjectFull] => Molecular targets
[Type] => general
)
[152] => Array
(
[SubjectFull] => Therapeutics. Pharmacology
[Type] => general
)
[153] => Array
(
[SubjectFull] => α-SMA, α smooth muscle actin
[Type] => general
)
[154] => Array
(
[SubjectFull] => SD, standard deviation
[Type] => general
)
[155] => Array
(
[SubjectFull] => business
[Type] => general
)
[156] => Array
(
[SubjectFull] => DAG, diacylglycerol
[Type] => general
)
[157] => Array
(
[SubjectFull] => GCLC, glutamate-cysteine ligase catalytic subunit
[Type] => general
)
[158] => Array
(
[SubjectFull] => Kidney disease
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hai-Yong Chen
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Yibin Feng
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cheng Zhang
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ning Wang
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sha Li
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Guoyi Tang
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 09
[Type] => published
[Y] => 2021
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 22113835
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 11
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Acta Pharmaceutica Sinica B
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |