Role of immune mediators in predicting hospitalization of SARS-CoV-2 positive patients
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[Data] => Role of immune mediators in predicting hospitalization of SARS-CoV-2 positive patients
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Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22S%2E+Ashrafzadeh-Kian%22">S. Ashrafzadeh-Kian</searchLink><br /><searchLink fieldCode="AR" term="%22M%2ER%2E+Campbell%22">M.R. Campbell</searchLink><br /><searchLink fieldCode="AR" term="%22J%2EC%2E+Jara+Aguirre%22">J.C. Jara Aguirre</searchLink><br /><searchLink fieldCode="AR" term="%22J%2E+Walsh%22">J. Walsh</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+Kumanovics%22">A. Kumanovics</searchLink><br /><searchLink fieldCode="AR" term="%22G%2E+Jenkinson%22">G. Jenkinson</searchLink><br /><searchLink fieldCode="AR" term="%22P%2E+Rinaldo%22">P. Rinaldo</searchLink><br /><searchLink fieldCode="AR" term="%22M%2ER%2E+Snyder%22">M.R. Snyder</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+Algeciras-Schimnich%22">A. Algeciras-Schimnich</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Cytokine ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier Ltd., 2021. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22LLOQ%2C+Lower+Limit+of+Quantification%22">LLOQ, Lower Limit of Quantification</searchLink><br /><searchLink fieldCode="DE" term="%22AMR%2C+Analytic+Measuring+Range%22">AMR, Analytic Measuring Range</searchLink><br /><searchLink fieldCode="DE" term="%22VEGF%2C+Vascular+endothelial+growth+factor%22">VEGF, Vascular endothelial growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22G-CSF%2C+Granulocyte+colony-stimulating+factor%22">G-CSF, Granulocyte colony-stimulating factor</searchLink><br /><searchLink fieldCode="DE" term="%22MIP-1α%2C+Macrophage+inflammatory+protein+1α%22">MIP-1α, Macrophage inflammatory protein 1α</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+Illness+Index%22">Severity of Illness Index</searchLink><br /><searchLink fieldCode="DE" term="%22MCP-1%2C+Monocyte+chemoattractant+protein-1%22">MCP-1, Monocyte chemoattractant protein-1</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology+and+Allergy%22">Immunology and Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22LIF%2C+Leukemia+inhibitory+factor%22">LIF, Leukemia inhibitory factor</searchLink><br /><searchLink fieldCode="DE" term="%22IL%2C+Interleukin%22">IL, Interleukin</searchLink><br /><searchLink fieldCode="DE" term="%22vWF-A2%2C+von+Willebrand+factor+A2+domain%22">vWF-A2, von Willebrand factor A2 domain</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+Mortality%22">Hospital Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22IM%2C+Immune+Mediator%22">IM, Immune Mediator</searchLink><br /><searchLink fieldCode="DE" term="%22sIL-6Rα%2C+Interleukin+6+receptor+α+%28soluble%29%22">sIL-6Rα, Interleukin 6 receptor α (soluble)</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+mediator%22">Immune mediator</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%2C+Coronavirus+disease+2019%22">COVID-19, Coronavirus disease 2019</searchLink><br /><searchLink fieldCode="DE" term="%22Hematology%22">Hematology</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22EN-RAGE%2FS100A12%2C+Extracellular+newly+identified+receptor+for+advanced+glycation+end+products+binding+protein%22">EN-RAGE/S100A12, Extracellular newly identified receptor for advanced glycation end products binding protein</searchLink><br /><searchLink fieldCode="DE" term="%22Hospitalization%22">Hospitalization</searchLink><br /><searchLink fieldCode="DE" term="%22C-Reactive+Protein%22">C-Reactive Protein</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink><br /><searchLink fieldCode="DE" term="%22Multiplex+assay%22">Multiplex assay</searchLink><br /><searchLink fieldCode="DE" term="%22Area+Under+Curve%22">Area Under Curve</searchLink><br /><searchLink fieldCode="DE" term="%22IL-6%2C+Interleukin+6%22">IL-6, Interleukin 6</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Receptors%2C+Chemokine%22">Receptors, Chemokine</searchLink><br /><searchLink fieldCode="DE" term="%22Chemokines%22">Chemokines</searchLink><br /><searchLink fieldCode="DE" term="%22IL-18%2C+Interleukin+18%22">IL-18, Interleukin 18</searchLink><br /><searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22PDGF%2C+Platelet-derived+growth+factor%22">PDGF, Platelet-derived growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22CLIR%2C+Collaborative+Laboratory+Integrated+Reports%22">CLIR, Collaborative Laboratory Integrated Reports</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22Fibrin+Fibrinogen+Degradation+Products%22">Fibrin Fibrinogen Degradation Products</searchLink><br /><searchLink fieldCode="DE" term="%22IFNα%2C+IFNβ%2C+IFNγ%2C+Interferon+α%2C+β%2C+γ%22">IFNα, IFNβ, IFNγ, Interferon α, β, γ</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Receptors%2C+Cytokine%22">Receptors, Cytokine</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+Biology%22">Molecular Biology</searchLink><br /><searchLink fieldCode="DE" term="%22IL-6%22">IL-6</searchLink><br /><searchLink fieldCode="DE" term="%22IL-10%2C+Interleukin+10%22">IL-10, Interleukin 10</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22IP-10%2C+CXCL-10%2C+Interferon+gamma-induced+protein+10%22">IP-10, CXCL-10, Interferon gamma-induced protein 10</searchLink><br /><searchLink fieldCode="DE" term="%22Length+of+Stay%22">Length of Stay</searchLink><br /><searchLink fieldCode="DE" term="%22IL-1β%2C+Interleukin+1+beta%22">IL-1β, Interleukin 1 beta</searchLink><br /><searchLink fieldCode="DE" term="%22Respiration%2C+Artificial%22">Respiration, Artificial</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%2C+Severe+Acute+Respiratory+Syndrome+Coronavirus+2%22">SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2</searchLink><br /><searchLink fieldCode="DE" term="%22ROC+Curve%22">ROC Curve</searchLink><br /><searchLink fieldCode="DE" term="%22TNF%2C+TNF-α%2C+Tumor+necrosis+factor-alpha%22">TNF, TNF-α, Tumor necrosis factor-alpha</searchLink><br /><searchLink fieldCode="DE" term="%22Ferritins%22">Ferritins</searchLink><br /><searchLink fieldCode="DE" term="%22GM-CSF%2C+Granulocyte-macrophage+colony-stimulating+factor%22">GM-CSF, Granulocyte-macrophage colony-stimulating factor</searchLink><br /><searchLink fieldCode="DE" term="%22sIL-2Rα%2C+Interleukin+2+receptor+α+%28soluble%29%22">sIL-2Rα, Interleukin 2 receptor α (soluble)</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22FGF%2C+Fibroblast+growth+factor%22">FGF, Fibroblast growth factor</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background Several immune mediators (IM) including cytokines, chemokines, and their receptors have been suggested to play a role in COVID-19 pathophysiology and severity. Aim To determine if early IM profiles are predictive of clinical outcome and which of the IMs tested possess the most clinical utility. Methods A custom bead-based multiplex assay was used to measure IM concentrations in a cohort of SARS-CoV-2 PCR positive patients (n = 326) with varying disease severities as determined by hospitalization status, length of hospital stay, and survival. Patient groups were compared, and clinical utility was assessed. Correlation plots were constructed to determine if significant relationships exist between the IMs in the setting of COVID-19. Results In PCR positive SARS-CoV-2 patients, IL-6 was the best predictor of the need for hospitalization and length of stay. Additionally, MCP-1 and sIL-2Rα were moderate predictors of the need for hospitalization. Hospitalized PCR positive SARS-CoV-2 patients displayed a notable correlation between sIL-2Rα and IL-18 (Spearman’s ρ = 0.48, P= ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1096-0023<br />1043-4666 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ea4dffd7340d4f462e705aa2180a11" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ea4dffd7340d4f462e705aa2180a11</link><br /><link linkTarget="URL" linkTerm="http://europepmc.org/articles/PMC8709828" linkWindow="_blank">http://europepmc.org/articles/PMC8709828</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....67ea4dffd7340d4f462e705aa2180a11 ) |
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