Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer
| العنوان: | Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer |
|---|---|
| المؤلفون: | Aïcha Zouggar, Joshua R. Haebe, Yannick D. Benoit |
| المصدر: | Genes, Vol 11, Iss 808, p 808 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:QH426-470, Colorectal cancer, colorectal cancer, Gut flora, Inflammatory bowel disease, Epigenome, 03 medical and health sciences, 0302 clinical medicine, Mediator, Genetics, medicine, Homeostasis, Humans, Epigenetics, Genetics (clinical), TET3, Inflammation, epigenetics, biology, Microbiota, LINE1, DNA Methylation, biology.organism_classification, medicine.disease, Intestinal epithelium, Gastrointestinal Microbiome, 3. Good health, lcsh:Genetics, 030104 developmental biology, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, Colorectal Neoplasms, Reprogramming |
| الوصف: | In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease. |
| تدمد: | 2073-4425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5c8e33e47a0adc44f12833eec163dcTest https://doi.org/10.3390/genes11070808Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f5c8e33e47a0adc44f12833eec163dc |
| قاعدة البيانات: | OpenAIRE |
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