Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis
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[Data] => Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis
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Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Stacy+K%2E+Thomas%22">Stacy K. Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Gregory+L%2E+Beatty%22">Gregory L. Beatty</searchLink><br /><searchLink fieldCode="AR" term="%22Jesse+Lee%22">Jesse Lee</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => EBioMedicine<br />EBioMedicine, Vol 53, Iss, Pp-(2020) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Elsevier, 2020. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2020 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22LIF%2C+leukaemia+inhibitory+factor%22">LIF, leukaemia inhibitory factor</searchLink><br /><searchLink fieldCode="DE" term="%22Neutrophils%22">Neutrophils</searchLink><br /><searchLink fieldCode="DE" term="%22PDAC%2C+pancreatic+ductal+adenocarcinoma%22">PDAC, pancreatic ductal adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AMedicine%22">lcsh:Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22EMT%2C+epithelial+to+mesenchymal+transition%22">EMT, epithelial to mesenchymal transition</searchLink><br /><searchLink fieldCode="DE" term="%22PSC%2C+pancreatic+stellate+cells%22">PSC, pancreatic stellate cells</searchLink><br /><searchLink fieldCode="DE" term="%22Wnt1%2C+Wnt+family+member+1%22">Wnt1, Wnt family member 1</searchLink><br /><searchLink fieldCode="DE" term="%22PDGF%2C+platelet-derived+growth+factor%22">PDGF, platelet-derived growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22Metastasis%22">Metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Prxx1%2C+paired-related+homeodomain+transcription+factor+1%22">Prxx1, paired-related homeodomain transcription factor 1</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+ductal+adenocarcinoma%22">Pancreatic ductal adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22MIF%2C+macrophage+migration+inhibitory+factor%22">MIF, macrophage migration inhibitory factor</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%2C+deoxyribonucleic+acid%22">DNA, deoxyribonucleic acid</searchLink><br /><searchLink fieldCode="DE" term="%22CXCL%2C+C-X-C+motif+chemokine+ligand%22">CXCL, C-X-C motif chemokine ligand</searchLink><br /><searchLink fieldCode="DE" term="%22SAA%2C+serum+amyloid+A%22">SAA, serum amyloid A</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22TGF%2C+transforming+growth+factor%22">TGF, transforming growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22TMEM%2C+tumor+microenvironments+of+metastasis%22">TMEM, tumor microenvironments of metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Series%22">Series</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AR5-920%22">lcsh:R5-920</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccines%22">Vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22CXCR%2C+CXC+chemokine+receptor%22">CXCR, CXC chemokine receptor</searchLink><br /><searchLink fieldCode="DE" term="%22PDGFR%2C+platelet-derived+growth+factor+receptor%22">PDGFR, platelet-derived growth factor receptor</searchLink><br /><searchLink fieldCode="DE" term="%22TNF%2C+tumor+necrosis+factor%22">TNF, tumor necrosis factor</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+evasion%22">Immune evasion</searchLink><br /><searchLink fieldCode="DE" term="%22General+Medicine%22">General Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Primary+tumor%22">Primary tumor</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+paradigms%22">Treatment paradigms</searchLink><br /><searchLink fieldCode="DE" term="%22MET%2C+mesenchymal-to-epithelial+transition%22">MET, mesenchymal-to-epithelial transition</searchLink><br /><searchLink fieldCode="DE" term="%22MMP%2C+matrix+metalloproteinase%22">MMP, matrix metalloproteinase</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+microenvironment%22">Tumor microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22030220+oncology+%26+carcinogenesis%22">030220 oncology & carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunotherapy%22">Immunotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AMedicine+%28General%29%22">lcsh:Medicine (General)</searchLink><br /><searchLink fieldCode="DE" term="%22PI3K%2C+phosphoinositide+3-kinase%22">PI3K, phosphoinositide 3-kinase</searchLink><br /><searchLink fieldCode="DE" term="%22TLR%2C+Toll-like+receptor%22">TLR, Toll-like receptor</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Zeb1%2C+zinc+finger+E-box-binding+homeobox+1%22">Zeb1, zinc finger E-box-binding homeobox 1</searchLink><br /><searchLink fieldCode="DE" term="%22General+Biochemistry%2C+Genetics+and+Molecular+Biology%22">General Biochemistry, Genetics and Molecular Biology</searchLink><br /><searchLink fieldCode="DE" term="%22SIRP%2C+signal+regulatory+protein%22">SIRP, signal regulatory protein</searchLink><br /><searchLink fieldCode="DE" term="%22STAT3%2C+signal+transducer+and+activation+of+transcription%22">STAT3, signal transducer and activation of transcription</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Paracrine+signalling%22">Paracrine signalling</searchLink><br /><searchLink fieldCode="DE" term="%22DCC%2C+disseminated+cancer+cell%22">DCC, disseminated cancer cell</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+cancer%22">Pancreatic cancer</searchLink><br /><searchLink fieldCode="DE" term="%22CSF%2C+colony+stimulating+factor%22">CSF, colony stimulating factor</searchLink><br /><searchLink fieldCode="DE" term="%22CCR%2C+C-C+chemokine+receptor%22">CCR, C-C chemokine receptor</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelial–mesenchymal+transition%22">Epithelial–mesenchymal transition</searchLink><br /><searchLink fieldCode="DE" term="%22CAF%2C+cancer-associated+fibroblasts%22">CAF, cancer-associated fibroblasts</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22EGF%2C+epidermal+growth+factor%22">EGF, epidermal growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3AR%22">lcsh:R</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosurveillance%22">Immunosurveillance</searchLink><br /><searchLink fieldCode="DE" term="%22LOX%2C+lysyl+oxidase%22">LOX, lysyl oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22PanIN%2C+pancreatic+intraepithelial+neoplasia%22">PanIN, pancreatic intraepithelial neoplasia</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+resistance%22">Therapeutic resistance</searchLink><br /><searchLink fieldCode="DE" term="%22TIMP%2C+tissue+inhibitor+matrix+metalloproteinase%22">TIMP, tissue inhibitor matrix metalloproteinase</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22TRAIL-R%2C+TNF-related+apoptosis-inducing+ligand+receptor%22">TRAIL-R, TNF-related apoptosis-inducing ligand receptor</searchLink><br /><searchLink fieldCode="DE" term="%22IL%2C+interleukin%22">IL, interleukin</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+Neoplasms%22">Pancreatic Neoplasms</searchLink><br /><searchLink fieldCode="DE" term="%22030104+developmental+biology%22">030104 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cell%22">Cancer cell</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+research%22">Cancer research</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding with colonization in distant tissues. Although cell-intrinsic features support the metastatic ability of cancer cells, permissive microenvironments within the primary organ and at sites of distant metastasis may be rate-limiting. Identification of cancer cell-extrinsic factors that regulate formation of these environments lend new therapeutic targets for intervening on the metastatic cascade. In addition, the bipolar, yet fundamental, role of the immune system in the metastatic process presents therapeutic opportunities. Herein, we review the current knowledge of the metastatic cascade in PDAC, and propose that genomically stable determinants of metastasis (e.g. the pro-metastatic niche and immune system) are actionable targets for preventing, containing, and treating metastasis in PDAC. Keywords: Inflammation, Cancer, Pancreatic ductal adenocarcinoma, Immunotherapy, Immune evasion, Treatment paradigms, T cells, Macrophages, Neutrophils, Tumor microenvironment, Immunosurveillance, Vaccines, Therapeutic resistance, Metastasis, Clinical trials ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2352-3964 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f38a4705938724fb049d0b00dcf2eb2" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f38a4705938724fb049d0b00dcf2eb2</link><br /><link linkTarget="URL" linkTerm="http://europepmc.org/articles/PMC7118576" linkWindow="_blank">http://europepmc.org/articles/PMC7118576</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....5f38a4705938724fb049d0b00dcf2eb2 ) |
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