Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
| العنوان: | Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure |
|---|---|
| المؤلفون: | Sarah Sarsfield, Yanshu Wang, Randy Schekman, Janna Merte, Devon Jensen, David D. Ginty, Kevin M. Wright |
| المصدر: | Nature cell biology |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Neural Tube, Vesicular Transport Proteins, Fluorescent Antibody Technique, Nerve Tissue Proteins, SEC24B, Biology, Endoplasmic Reticulum, Article, Immunoenzyme Techniques, Mice, Mice, Neurologic Mutants, 03 medical and health sciences, 0302 clinical medicine, Cell polarity, Craniorachischisis, medicine, Animals, Immunoprecipitation, Neural Tube Defects, COPII, 030304 developmental biology, Mice, Inbred C3H, 0303 health sciences, Convergent extension, Endoplasmic reticulum, Neural tube, Cell Polarity, Cell Biology, COP-Coated Vesicles, Embryo, Mammalian, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Spinal Cord, 030217 neurology & neurosurgery, Hair, Signal Transduction |
| الوصف: | Craniorachischisis is a rare but severe birth defect that results in a completely open neural tube. Mouse mutants in planar cell polarity (PCP) signalling components have deficits in the morphological movements of convergent extension that result in craniorachischisis. Using a forward genetic screen in mice, we identified Sec24b, a cargo-sorting member of the core complex of the endoplasmic reticulum (ER)-to-Golgi transport vesicle COPII, as critical for neural tube closure. Sec24bY613 mutant mice exhibit craniorachischisis, deficiencies in convergent extension and other PCP-related phenotypes. Vangl2, a key component of the PCP-signalling pathway critical for convergent extension, is selectively sorted into COPII vesicles by Sec24b. Moreover, Sec24bY613 genetically interacts with a loss-of-function Vangl2 allele (Vangl2LP), causing a marked increase in the prevalence of spina bifida. Interestingly, the Vangl2 looptail point mutants Vangl2D255E and Vangl2S464N, known to cause defects in convergent extension, fail to sort into COPII vesicles and are trapped in the ER. Thus, during COPII vesicle formation, Sec24b shows cargo specificity for a core PCP component, Vangl2, of which proper ER-to-Golgi transport is essential for the establishment of PCP, convergent extension and closure of the neural tube. |
| تدمد: | 1476-4679 1465-7392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b82962c125e2a46e46bb887427f32a1Test https://doi.org/10.1038/ncb2002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b82962c125e2a46e46bb887427f32a1 |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....5b82962c125e2a46e46bb887427f32a1 792 3 unknown 792.141235351563 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....5b82962c125e2a46e46bb887427f32a1&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Sarah+Sarsfield%22">Sarah Sarsfield</searchLink><br /><searchLink fieldCode="AR" term="%22Yanshu+Wang%22">Yanshu Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Randy+Schekman%22">Randy Schekman</searchLink><br /><searchLink fieldCode="AR" term="%22Janna+Merte%22">Janna Merte</searchLink><br /><searchLink fieldCode="AR" term="%22Devon+Jensen%22">Devon Jensen</searchLink><br /><searchLink fieldCode="AR" term="%22David+D%2E+Ginty%22">David D. Ginty</searchLink><br /><searchLink fieldCode="AR" term="%22Kevin+M%2E+Wright%22">Kevin M. Wright</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Nature cell biology ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Springer Science and Business Media LLC, 2009. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2009 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+Tube%22">Neural Tube</searchLink><br /><searchLink fieldCode="DE" term="%22Vesicular+Transport+Proteins%22">Vesicular Transport Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescent+Antibody+Technique%22">Fluorescent Antibody Technique</searchLink><br /><searchLink fieldCode="DE" term="%22Nerve+Tissue+Proteins%22">Nerve Tissue Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22SEC24B%22">SEC24B</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Endoplasmic+Reticulum%22">Endoplasmic Reticulum</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoenzyme+Techniques%22">Immunoenzyme Techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%2C+Neurologic+Mutants%22">Mice, Neurologic Mutants</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+polarity%22">Cell polarity</searchLink><br /><searchLink fieldCode="DE" term="%22Craniorachischisis%22">Craniorachischisis</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoprecipitation%22">Immunoprecipitation</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+Tube+Defects%22">Neural Tube Defects</searchLink><br /><searchLink fieldCode="DE" term="%22COPII%22">COPII</searchLink><br /><searchLink fieldCode="DE" term="%22030304+developmental+biology%22">030304 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%2C+Inbred+C3H%22">Mice, Inbred C3H</searchLink><br /><searchLink fieldCode="DE" term="%220303+health+sciences%22">0303 health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Convergent+extension%22">Convergent extension</searchLink><br /><searchLink fieldCode="DE" term="%22Endoplasmic+reticulum%22">Endoplasmic reticulum</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+tube%22">Neural tube</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Polarity%22">Cell Polarity</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Biology%22">Cell Biology</searchLink><br /><searchLink fieldCode="DE" term="%22COP-Coated+Vesicles%22">COP-Coated Vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22Embryo%2C+Mammalian%22">Embryo, Mammalian</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+biology%22">Cell biology</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%2C+Inbred+C57BL%22">Mice, Inbred C57BL</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22Spinal+Cord%22">Spinal Cord</searchLink><br /><searchLink fieldCode="DE" term="%22030217+neurology+%26+neurosurgery%22">030217 neurology & neurosurgery</searchLink><br /><searchLink fieldCode="DE" term="%22Hair%22">Hair</searchLink><br /><searchLink fieldCode="DE" term="%22Signal+Transduction%22">Signal Transduction</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Craniorachischisis is a rare but severe birth defect that results in a completely open neural tube. Mouse mutants in planar cell polarity (PCP) signalling components have deficits in the morphological movements of convergent extension that result in craniorachischisis. Using a forward genetic screen in mice, we identified Sec24b, a cargo-sorting member of the core complex of the endoplasmic reticulum (ER)-to-Golgi transport vesicle COPII, as critical for neural tube closure. Sec24bY613 mutant mice exhibit craniorachischisis, deficiencies in convergent extension and other PCP-related phenotypes. Vangl2, a key component of the PCP-signalling pathway critical for convergent extension, is selectively sorted into COPII vesicles by Sec24b. Moreover, Sec24bY613 genetically interacts with a loss-of-function Vangl2 allele (Vangl2LP), causing a marked increase in the prevalence of spina bifida. Interestingly, the Vangl2 looptail point mutants Vangl2D255E and Vangl2S464N, known to cause defects in convergent extension, fail to sort into COPII vesicles and are trapped in the ER. Thus, during COPII vesicle formation, Sec24b shows cargo specificity for a core PCP component, Vangl2, of which proper ER-to-Golgi transport is essential for the establishment of PCP, convergent extension and closure of the neural tube. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1476-4679<br />1465-7392 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b82962c125e2a46e46bb887427f32a1" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b82962c125e2a46e46bb887427f32a1</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1038/ncb2002" linkWindow="_blank">https://doi.org/10.1038/ncb2002</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....5b82962c125e2a46e46bb887427f32a1 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 41
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Male
[Type] => general
)
[1] => Array
(
[SubjectFull] => Neural Tube
[Type] => general
)
[2] => Array
(
[SubjectFull] => Vesicular Transport Proteins
[Type] => general
)
[3] => Array
(
[SubjectFull] => Fluorescent Antibody Technique
[Type] => general
)
[4] => Array
(
[SubjectFull] => Nerve Tissue Proteins
[Type] => general
)
[5] => Array
(
[SubjectFull] => SEC24B
[Type] => general
)
[6] => Array
(
[SubjectFull] => Biology
[Type] => general
)
[7] => Array
(
[SubjectFull] => Endoplasmic Reticulum
[Type] => general
)
[8] => Array
(
[SubjectFull] => Article
[Type] => general
)
[9] => Array
(
[SubjectFull] => Immunoenzyme Techniques
[Type] => general
)
[10] => Array
(
[SubjectFull] => Mice
[Type] => general
)
[11] => Array
(
[SubjectFull] => Mice, Neurologic Mutants
[Type] => general
)
[12] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[13] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[14] => Array
(
[SubjectFull] => Cell polarity
[Type] => general
)
[15] => Array
(
[SubjectFull] => Craniorachischisis
[Type] => general
)
[16] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[17] => Array
(
[SubjectFull] => Animals
[Type] => general
)
[18] => Array
(
[SubjectFull] => Immunoprecipitation
[Type] => general
)
[19] => Array
(
[SubjectFull] => Neural Tube Defects
[Type] => general
)
[20] => Array
(
[SubjectFull] => COPII
[Type] => general
)
[21] => Array
(
[SubjectFull] => 030304 developmental biology
[Type] => general
)
[22] => Array
(
[SubjectFull] => Mice, Inbred C3H
[Type] => general
)
[23] => Array
(
[SubjectFull] => 0303 health sciences
[Type] => general
)
[24] => Array
(
[SubjectFull] => Convergent extension
[Type] => general
)
[25] => Array
(
[SubjectFull] => Endoplasmic reticulum
[Type] => general
)
[26] => Array
(
[SubjectFull] => Neural tube
[Type] => general
)
[27] => Array
(
[SubjectFull] => Cell Polarity
[Type] => general
)
[28] => Array
(
[SubjectFull] => Cell Biology
[Type] => general
)
[29] => Array
(
[SubjectFull] => COP-Coated Vesicles
[Type] => general
)
[30] => Array
(
[SubjectFull] => Embryo, Mammalian
[Type] => general
)
[31] => Array
(
[SubjectFull] => Cell biology
[Type] => general
)
[32] => Array
(
[SubjectFull] => Mice, Inbred C57BL
[Type] => general
)
[33] => Array
(
[SubjectFull] => medicine.anatomical_structure
[Type] => general
)
[34] => Array
(
[SubjectFull] => Spinal Cord
[Type] => general
)
[35] => Array
(
[SubjectFull] => 030217 neurology & neurosurgery
[Type] => general
)
[36] => Array
(
[SubjectFull] => Hair
[Type] => general
)
[37] => Array
(
[SubjectFull] => Signal Transduction
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sarah Sarsfield
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Yanshu Wang
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Randy Schekman
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Janna Merte
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Devon Jensen
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => David D. Ginty
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kevin M. Wright
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 06
[M] => 12
[Type] => published
[Y] => 2009
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 14764679
)
[1] => Array
(
[Type] => issn-print
[Value] => 14657392
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[3] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 12
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Nature Cell Biology
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |