Stimulation of cardiac apoptosis in essential hypertension: potential role of angiotensin II
| العنوان: | Stimulation of cardiac apoptosis in essential hypertension: potential role of angiotensin II |
|---|---|
| المؤلفون: | Ramón Querejeta, Begoña López, Arantxa González, Susana Ravassa, Mariano Larman, Javier Díez, M.A. Fortuño |
| المصدر: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname |
| بيانات النشر: | American Heart Association, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, Angiotensin receptor, medicine.medical_specialty, Heart Ventricles, Blood Pressure, Apoptosis, Essential hypertension, Receptor, Angiotensin, Type 1, Losartan, Angiotensin Receptor Antagonists, Proto-Oncogene Proteins, Internal medicine, Internal Medicine, medicine, Humans, Amlodipine, Antihypertensive Agents, Aged, bcl-2-Associated X Protein, Ischemic cardiomyopathy, business.industry, Myocardium, Angiotensin II, Heart, Middle Aged, Calcium Channel Blockers, medicine.disease, Hypertension, essential, Blood pressure, Endocrinology, Proto-Oncogene Proteins c-bcl-2, Heart failure, Hypertension, Female, business, medicine.drug |
| الوصف: | We investigated whether cardiac apoptosis is stimulated in the heart of hypertensive patients and whether angiotensin II plays a role in such alteration. The study was performed in 28 patients with essential hypertension and no evidence of either ischemic cardiomyopathy or heart failure. After randomization, 14 patients were assigned to losartan and 14 patients to amlodipine treatment. At baseline and after 12 months, right septal endomyocardial biopsies were performed, and the number of apoptotic nuclei was assessed by DNA end-labeling (TUNEL). In addition, immunostaining for the active form of caspase-3 was also performed to assess apoptosis. Compared with normotensive autopsied hearts, both cardiomyocyte and noncardiomyocyte apoptosis were increased ( P P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2fa8ea341aa78b4cebb3935345eb7eTest https://hdl.handle.net/10171/19904Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a2fa8ea341aa78b4cebb3935345eb7e |
| قاعدة البيانات: | OpenAIRE |
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