Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction
| العنوان: | Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction |
|---|---|
| المؤلفون: | Zhanchen, Dong, Jianyu, Wang, Tianming, Qiu, Jialu, Wu, Yu, An, Xiaoxia, Shi, Xiance, Sun, Liping, Jiang, Xiaofang, Liu, Guang, Yang, Jun, Cao, Xiaofeng, Yao |
| المصدر: | Science of The Total Environment. 825:153933 |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Fluorocarbons, Environmental Engineering, Voltage-Dependent Anion Channel 1, Calcium-Binding Proteins, Mitochondrial Membrane Transport Proteins, Pollution, Mitochondria, Mice, Inbred C57BL, Mice, Alkanesulfonic Acids, Liver, Tubulin, Autophagy, Animals, Humans, Environmental Chemistry, Calcium, Insulin Resistance, Cation Transport Proteins, Waste Management and Disposal |
| الوصف: | Perfluorooctane sulfonate (PFOS), one kind of persistent organic pollutants, is associated with insulin resistance (IR) in general population. However, the exact mechanism is still obscure. In this study, we found that 50 μM PFOS caused IR in L-02 hepatocytes after 1 h, and induced autophagy and mitochondrial calcium (Ca |
| تدمد: | 0048-9697 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d78593d0d1936fd0b1b5d2435b6751Test https://doi.org/10.1016/j.scitotenv.2022.153933Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....59d78593d0d1936fd0b1b5d2435b6751 |
| قاعدة البيانات: | OpenAIRE |
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