Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression
| العنوان: | Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression |
|---|---|
| المؤلفون: | Valeria A. Sansone, Andrea Barp, Christian Lunetta, Andrea Lizio, Luca Mauro, Francesca Gerardi, Claudia Tarlarini |
| المصدر: | Clinical Neurophysiology. 132:1564-1571 |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Oncology, Vital capacity, medicine.medical_specialty, Vital Capacity, Neural Conduction, 050105 experimental psychology, Cohort Studies, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Physiology (medical), Internal medicine, Outcome Assessment, Health Care, medicine, Humans, 0501 psychology and cognitive sciences, In patient, Amyotrophic lateral sclerosis, Aged, medicine.diagnostic_test, Electromyography, business.industry, Amyotrophic Lateral Sclerosis, 05 social sciences, Disease progression, Outcome measures, Middle Aged, Neurophysiology, medicine.disease, Sensory Systems, Cross-Sectional Studies, Neurology, Disease Progression, Nerve conduction study, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | This study examined neurophysiological (NI), split-hand (SI) and split-leg (SLI) index in patients with amyotrophic lateral sclerosis (ALS), and their correlation with functional status, disease duration, staging and survival.Eighty-two patients underwent nerve conduction study to analyze NI, SI and SLI. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), disease progression rate (ΔFS), Milano-Torino (MiToS) and King's staging systems, Forced Vital Capacity (FVC), and survival data were collected.Both NI and SI indices were significantly associated with ALSFRS-R, MiToS, King's and FVC. Slow progressor patients (ΔFS 0.5) reported a significantly higher NI and SI values compared to both normal (0.5 ≤ ΔFS 1.00) and fast progressors (ΔFS ≥ 1.0). After dichotomizing patients in slow progressors (ΔFS 0.5) and not-slow progressors (ΔFS ≥ 0.5), a combination of SI index and disease duration revealed to be the best prediction model to discriminate patients in accordance with their disease progression (c-index: 0.92), leading to a new prognostic index: the 'Split-Hand prognostic index' (SHpi).SI and NI are correlated with functional status and FVC. SHpi index could represent an useful tool to discriminate patients in accordance with their disease progression.These data provide novel evidence of neurophysiological indices as promising biomarkers in ALS. |
| تدمد: | 1388-2457 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e13bde8be9467f93c88b275fa8aa6c2Test https://doi.org/10.1016/j.clinph.2021.02.394Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4e13bde8be9467f93c88b275fa8aa6c2 |
| قاعدة البيانات: | OpenAIRE |
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