Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancer
| العنوان: | Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancer |
|---|---|
| المؤلفون: | Chin-Shaw Tsai S, Cheau-Feng Lin F, Jeng Yc, Huang Ty, Chou Mc, Chi Cs |
| المصدر: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 19(4) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Mitochondrial DNA, DNA Copy Number Variations, Health, Toxicology and Mutagenesis, Clinical Biochemistry, Context (language use), Biology, Bioinformatics, Real-Time Polymerase Chain Reaction, Biochemistry, DNA, Mitochondrial, medicine, Humans, Aged, DNA Primers, Base Sequence, Head and neck cancer, Patient survival, Middle Aged, Tumor Pathology, medicine.disease, Prognosis, Survival Rate, Head and Neck Neoplasms, Female |
| الوصف: | Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers.To investigate mtDNA copy number in head and neck cancer (HNC).mtDNA copy number was determined and compared between HNC patients and malignancy-free controls.The mtDNA copy number was significantly higher in HNC patients, increased with cancer progression and correlated negatively with patient survival.mtDNA copy number appears to be associated with HNC stage and survival, but confirmation requires similar studies in larger cohorts.Studies to establish the nature of the relationship between mtDNA copy number and HNC are warranted. |
| تدمد: | 1366-5804 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bba1325a7a29702012f525664e91547Test https://pubmed.ncbi.nlm.nih.gov/24773072Test |
| رقم الانضمام: | edsair.doi.dedup.....4bba1325a7a29702012f525664e91547 |
| قاعدة البيانات: | OpenAIRE |
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