Prey sensing and response in a nematode-trapping fungus is governed by the MAPK pheromone response pathway
العنوان: | Prey sensing and response in a nematode-trapping fungus is governed by the MAPK pheromone response pathway |
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المؤلفون: | Yen-Ping Hsueh, Sheng-An Chen, Frank C. Schroeder, Hung-Che Lin |
المصدر: | Genetics |
بيانات النشر: | Oxford University Press (OUP), 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | Mitogen-Activated Protein Kinase Kinases, MAPK/ERK pathway, Genetics, 0303 health sciences, Nematoda, Hypha, MAP Kinase Signaling System, 030306 microbiology, Mutant, Morphogenesis, Conidiation, Spores, Fungal, Biology, Fungal Proteins, 03 medical and health sciences, Ascomycota, Fus3, Animals, Fungal Genetics, Gene, Transcription factor, Transcription Factors, 030304 developmental biology |
الوصف: | Detection of surrounding organisms in the environment plays a major role in the evolution of interspecies interactions, such as predator–prey relationships. Nematode-trapping fungi (NTF) are predators that develop specialized trap structures to capture, kill, and consume nematodes when food sources are limited. Despite the identification of various factors that induce trap morphogenesis, the mechanisms underlying the differentiation process have remained largely unclear. Here, we demonstrate that the highly conserved pheromone-response MAPK pathway is essential for sensing ascarosides, a conserved molecular signature of nemaotdes, and is required for the predatory lifestyle switch in the NTF Arthrobotrys oligospora. Gene deletion of STE7 (MAPKK) and FUS3 (MAPK) abolished nematode-induced trap morphogenesis and conidiation and impaired the growth of hyphae. The conserved transcription factor Ste12 acting downstream of the pheromone-response pathway also plays a vital role in the predation of A. oligospora. Transcriptional profiling of a ste12 mutant identified a small subset of genes with diverse functions that are Ste12 dependent and could trigger trap differentiation. Our work has revealed that A. oligospora perceives and interprets the ascarosides produced by nematodes via the conserved pheromone signaling pathway in fungi, providing molecular insights into the mechanisms of communication between a fungal predator and its nematode prey. |
تدمد: | 1943-2631 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4679da86231cdcefbf2f8f34b8be00b7Test https://doi.org/10.1093/genetics/iyaa008Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....4679da86231cdcefbf2f8f34b8be00b7 |
قاعدة البيانات: | OpenAIRE |
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