Cullin-RING Ligase 5: Functional characterization and its role in human cancers
| العنوان: | Cullin-RING Ligase 5: Functional characterization and its role in human cancers |
|---|---|
| المؤلفون: | Yongchao Zhao, Yi Sun, Xiufang Xiong |
| المصدر: | Seminars in cancer biology. 67(Pt 2) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Ubiquitin-Protein Ligases, Inflammation, Suppressor of Cytokine Signaling Proteins, medicine.disease_cause, Antiviral Agents, law.invention, 03 medical and health sciences, Viral Proteins, 0302 clinical medicine, law, Neoplasms, medicine, Humans, Molecular Targeted Therapy, Receptor, chemistry.chemical_classification, DNA ligase, biology, Signal transducing adaptor protein, Cullin Proteins, Cell biology, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Multiprotein Complexes, biology.protein, Suppressor, medicine.symptom, Carcinogenesis, Carrier Proteins, CUL5, Cullin |
| الوصف: | Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS. Through targeting a variety of substrates for proteasomal degradation or modulating various protein-protein interactions, CRL5 is involved in regulation of many biological processes, such as cytokine signal transduction, inflammation, viral infection, and oncogenesis. As many substrates of CRL5 are well-known oncoproteins or tumor suppressors, abnormal regulation of CRL5 is commonly found in human cancers. In this review, we first briefly introduce each of CRL5 components, and then discuss the biological processes regulated by four members of SOCS-box-containing substrate receptor family through substrate degradation. We next describe how CRL5 is hijacked by a variety of viral proteins to degrade host anti-viral proteins, which facilitates virus infection. We further discuss the regulation of CUL5 and its various roles in human cancers, acting as either a tumor suppressor or an oncoprotein in a context-dependent manner. Finally, we propose novel insights for future perspectives on the validation of cullin5 and other CRL5 components as potential targets, and possible targeting strategies to discover CRL5 inhibitors for anti-cancer and anti-virus therapies. |
| تدمد: | 1096-3650 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dc5e9be5156892fbec4bb6fe97b779Test https://pubmed.ncbi.nlm.nih.gov/32334051Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....44dc5e9be5156892fbec4bb6fe97b779 |
| قاعدة البيانات: | OpenAIRE |
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