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Serum cystatin C advantageous compared with serum creatinine in the detection of mild but not severe diabetic nephropathy

التفاصيل البيبلوغرافية
العنوان: Serum cystatin C advantageous compared with serum creatinine in the detection of mild but not severe diabetic nephropathy
المؤلفون: Gunnar Sterner, Kristina Norrgren, Anders Grubb, Göran Sundkvist, J-Å Nilsson, Anders Christensson
المصدر: Journal of Internal Medicine; 256(6), pp 510-518 (2004)
بيانات النشر: Blackwell Publishing, 2004.
سنة النشر: 2004
مصطلحات موضوعية: Cystatins/blood, Male, Kidney Function Tests, urologic and male genital diseases, Diabetic nephropathy, chemistry.chemical_compound, Kidney Function Tests/methods, Diabetic Nephropathies, Prospective Studies, biology, Age Factors, Diabetic Nephropathies/blood, Middle Aged, female genital diseases and pregnancy complications, Creatinine, Female, Cystatin, Diabetes Mellitus, Type 2/blood, Glomerular Filtration Rate, Radiology, Nuclear Medicine and Medical Imaging, Adult, medicine.medical_specialty, Urology, Renal function, Pharmacology and Toxicology, Endocrinology and Diabetes, Nephropathy, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Cystatin C, Aged, business.industry, Diabetes Mellitus, Type 1/blood, Creatinine/blood, medicine.disease, Cystatins, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, Albuminuria/etiology, ROC Curve, chemistry, biology.protein, Clinical Medicine, Medicinal Chemistry, business, Biomarkers, Biomarkers/blood, Kidney disease
الوصف: OBJECTIVE: To determine whether serum cystatin C is more accurate than serum creatinine in the detection of diabetic nephropathy, also after adjustment for age.METHODS: Forty-one patients with type 1 and 82 patients with type 2 diabetes were evaluated with serum creatinine, serum cystatin C, and (51)Cr-EDTA clearance (reference method). Cystatin C was measured by a particle-enhanced turbidimetric method and creatinine by an enzymatic method. Statistical estimations were performed both without and with age adjustment created by z-scores for (51)Cr-EDTA clearance, creatinine, and cystatin C. The cut-off levels for glomerular filtration rate (GFR) ((51)Cr-EDTA clearance) were 60 and 80 mL min(-1) 1.73 m(-2), respectively, in absolute values and 80, 90 and 95% CIs, respectively, in age-adjusted values (z-scores).RESULTS: Estimations without age adjustment showed significantly (P = 0.0132) closer correlation for cystatin C (r = 0.817) versus (51)Cr-EDTA clearance as compared with creatinine (r = 0.678). However, when using age-adjusted values, the correlation for cystatin C and creatinine, respectively, versus (51)Cr-EDTA clearance did not differ. When comparing the diagnostic utilities for serum cystatin C versus serum creatinine in manifest renal impairment (GFR < 60 mL min(-1) 1.73 m(-2) or z-scores
وصف الملف: application/pdf
اللغة: English
تدمد: 1365-2796
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435231efbc33bea0810f0ccbf9d6f06dTest
http://lup.lub.lu.se/record/130735Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....435231efbc33bea0810f0ccbf9d6f06d
قاعدة البيانات: OpenAIRE
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