Basal insulin delivery reduction for exercise in type 1 diabetes: finding the sweet spot
| العنوان: | Basal insulin delivery reduction for exercise in type 1 diabetes: finding the sweet spot |
|---|---|
| المؤلفون: | Lalantha Leelarathna, Hood Thabit |
| المصدر: | Diabetologia |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | Adult, Male, Insulin pump, Blood Glucose, medicine.medical_specialty, medicine.medical_treatment, Continuous subcutaneous insulin infusion, Endocrinology, Diabetes and Metabolism, Insulins, 030209 endocrinology & metabolism, Basal insulin delivery, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Bolus (medicine), Internal medicine, medicine, Internal Medicine, Aerobic exercise, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, Exercise, Type 1 diabetes, Cross-Over Studies, business.industry, Middle Aged, medicine.disease, Crossover study, Hypoglycemia, 3. Good health, Clinical trial, Endocrinology, Diabetes Mellitus, Type 1, Commentary, Female, business, Hypoglycaemia, Hormone |
| الوصف: | Exercise poses significant challenges to glucose management in type 1 diabetes. In spite of careful planning and manipulation of subcutaneous insulin administration, increased risk of hypoglycaemia and glycaemic variability during and after exercise may occur as a result of inherent delays in insulin action and impaired counter-regulatory hormone responses. Various strategies to mitigate this issue have been advocated in clinical practice, including ingestion of supplementary carbohydrate prior to exercise, reducing background and pre-meal insulin bolus and performing bouts of resistance/high intensity exercise before aerobic exercise. Insulin pump therapy, considered the most physiological form of insulin replacement for type 1 diabetes allows modulation of basal insulin delivery before, during and after exercise. However uncertainty remains regarding the optimal strategy to reduce basal insulin delivery and its efficacy. In this issue of Diabetologia, McAuley and colleagues (DOI: 10.1007/s00125-016-3981-9 ) report on the impact of a 50% reduction of basal insulin delivery before, during and after moderate-intensity aerobic exercise. Results from this study may contribute to a better understanding of the effects of basal insulin delivery manipulation and may aid in devising therapeutic approaches for glucose management during exercise. |
| اللغة: | English |
| تدمد: | 0012-186X |
| DOI: | 10.1007/s00125-016-4010-8 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377ef0bacfea312eb577fd054253d3ceTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....377ef0bacfea312eb577fd054253d3ce |
| قاعدة البيانات: | OpenAIRE |
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