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Can Elderly Patients with Peritoneal Metastasis Induced by Appendiceal or Colorectal Tumours Benefit from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

التفاصيل البيبلوغرافية
العنوان: Can Elderly Patients with Peritoneal Metastasis Induced by Appendiceal or Colorectal Tumours Benefit from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?
المؤلفون: Jianwei Liang, Haitao Zhou, Sicheng Zhou, Wei Pei, Zhixiang Zhou, Qiang Feng, Zheng Jiang, Xishan Wang, Qian Liu, Jing Zhang
المصدر: Clinical Interventions in Aging
بيانات النشر: Dove Press, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, Male, China, medicine.medical_specialty, Peritoneal metastasis, morbidity, Hyperthermic Intraperitoneal Chemotherapy, elderly patients, survival, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Survival rate, Peritoneal Neoplasms, Aged, Retrospective Studies, Original Research, HIPEC, business.industry, Cytoreduction Surgical Procedures, General Medicine, Perioperative, Middle Aged, Prognosis, Surgery, Survival Rate, Appendiceal Neoplasms, Chemotherapy, Adjuvant, Clinical Interventions in Aging, Female, Hyperthermic intraperitoneal chemotherapy, Geriatrics and Gerontology, Colorectal Neoplasms, Cytoreductive surgery, business, 030217 neurology & neurosurgery, CRS
الوصف: Sicheng Zhou,1,* Qiang Feng,1,* Jing Zhang,2 Haitao Zhou,1 Zheng Jiang,1 Jianwei Liang,1 Wei Pei,1 Qian Liu,1 Zhixiang Zhou,1 Xishan Wang1 1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Department of Abdominal Surgery, Huanxing Cancer Hospital, Beijing, 100122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianwei Liang; Wei Pei Email Liangjw1976@163.com; peiweifbwk@163.comPurpose: Cytoreductive surgery (CRS) added with hyperthermic intraperitoneal chemotherapy (HIPEC) can improve the survival rate of certain patients with peritoneal metastasis (PM). However, the perioperative safety and long-term survival of this intricate and possibly life-threatening procedure in elderly patients (≥ 65 years) remain controversial.Methods: Patients with PM due to appendiceal or colorectal tumours who underwent CRS/HIPEC were evaluated systematically at the National Cancer Center of China and the Huanxing Cancer Hospital between June 2017 and June 2019. The recruited subjects were retrospectively categorized into elderly (age ≥ 65) and non-elderly (age< 65) groups according to their age. Clinical and pathological features, postoperative outcomes, and prognoses were gathered and analysed.Results: Both groups had similar overall morbidity (56.0% vs 38.7%, P=0.130) and grade 3/4 morbidity (28.0% vs 20.0%, P=0.403) after CRS/HIPEC. However, more patients in the elderly group suffered from ileus postoperatively (16.0% vs 2.6%, P=0.033). After a follow-up period of a median of 20 months, it was concluded that elderly patients had significantly worse 3-year overall survival (OS) than non-elderly patients (16.3% vs 51.4%, P=0.001). Independent prognostic factors were identified to be a high peritoneal carcinomatosis index (PCI) score (HR, 1.10, 95% CI, 1.04– 1.16; P=0.001) and age ≥ 65 (HR, 2.42, 95% CI, 1.32– 4.45; P=0.004) were independent prognostic factors through cox regression analysis.Conclusion: CRS and HIPEC are related with an elevated prevalence of postoperative ileus but not with the overall morbidity or the grade 3/4 morbidity in elderly patients. However, since worse survival outcomes were observed more commonly in elderly patients compared to younger patients from CRS+HIPEC, this complex and potentially life-threatening procedure should be considered carefully in patients aged ≥ 65 years.Keywords: elderly patients, CRS, HIPEC, morbidity, survival
وصف الملف: text/html
اللغة: English
تدمد: 1178-1998
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a89e22f76f3630869f659bcb724c58Test
https://www.dovepress.com/can-elderly-patients-with-peritoneal-metastasis-induced-by-appendiceal-peer-reviewed-article-CIATest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....36a89e22f76f3630869f659bcb724c58
قاعدة البيانات: OpenAIRE
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