Comparison of differences in bone microarchitecture in adult- versus juvenile-onset type 1 diabetes Asian males versus non-diabetes males: an observational cross-sectional pilot study
| العنوان: | Comparison of differences in bone microarchitecture in adult- versus juvenile-onset type 1 diabetes Asian males versus non-diabetes males: an observational cross-sectional pilot study |
|---|---|
| المؤلفون: | Jie Yu, Qun Xu, Lingling Xu, Yanfang Hou, Yuxiu Li, Huabing Zhang, Wei Li, Ou Wang, Weibo Xia, Fan Ping |
| المصدر: | Endocrine |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Fracture risk, Endocrinology, Diabetes and Metabolism, Urology, Pilot Projects, 030209 endocrinology & metabolism, Bone and Bones, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Endocrinology, Bone Density, Diabetes mellitus, Bone mineral density, medicine, Humans, Tibia, Quantitative computed tomography, Bone mineral, Type 1 diabetes, medicine.diagnostic_test, business.industry, Bone microarchitecture, medicine.disease, Radius, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030104 developmental biology, Juvenile onset, Original Article, Observational study, business, Body mass index |
| الوصف: | Purpose Evidence about bone microarchitecture in Asian type 1 diabetes (T1D) patients is lacking. We assessed the bone microarchitecture in T1D patients versus controls and compare the differences between juvenile-onset and adult-onset T1D patients. Methods This cross-sectional study recruited 32 Asian males with T1D and 32 age-, sex-, and body mass index (BMI)-matched controls. Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) for ultradistal nondominant radius and tibia were performed. The data were analyzed using Student’s t test and analysis of covariance. Results Among the patients, 15 had juvenile-onset T1D, with a median disease duration of 11 years, and 17 had adult-onset T1D, with a median disease duration of 7 years. At the radius, adult-onset and juvenile-onset T1D patients had lower total volumetric bone mineral density (vBMD), trabecular vBMD, trabecular bone volume fraction (BV/TV), and trabecular thickness (Tb.Th) (p p p Conclusions T1D patients were associated with compromised bone microarchitecture, adult-onset and juvenile-onset T1D patients demonstrated some differences in cortical and trabecular microarchitecture. |
| تدمد: | 1559-0100 1355-008X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309e618945a484d78bcf0713b29a48abTest https://doi.org/10.1007/s12020-020-02480-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....309e618945a484d78bcf0713b29a48ab |
| قاعدة البيانات: | OpenAIRE |
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We assessed the bone microarchitecture in T1D patients versus controls and compare the differences between juvenile-onset and adult-onset T1D patients. Methods This cross-sectional study recruited 32 Asian males with T1D and 32 age-, sex-, and body mass index (BMI)-matched controls. Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) for ultradistal nondominant radius and tibia were performed. The data were analyzed using Student’s t test and analysis of covariance. Results Among the patients, 15 had juvenile-onset T1D, with a median disease duration of 11 years, and 17 had adult-onset T1D, with a median disease duration of 7 years. 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