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Time in Range in Children with Type 1 Diabetes Using Treatment Strategies Based on Nonautomated Insulin Delivery Systems in the Real World

التفاصيل البيبلوغرافية
العنوان: Time in Range in Children with Type 1 Diabetes Using Treatment Strategies Based on Nonautomated Insulin Delivery Systems in the Real World
المؤلفون: N. Rapini, Luca Zagaroli, Giulio Maltoni, Fortunato Lombardo, Andrea Scaramuzza, Enza Mozzillo, Davide Tinti, Ivana Rabbone, Riccardo Bonfanti, Valentino Cherubini, Claudio Maffeis, Elena De Nitto, Andrea Rigamonti, Giuseppina Salzano, Marta Bassi, Sonia Toni, Alberto Casertano, Stefano Zucchini, Rosaria Gesuita, Marco Marigliano, Riccardo Schiaffini, Nicola Minuto, Antonio Iannilli
المساهمون: Cherubini, V., Bonfanti, R., Casertano, A., De Nitto, E., Iannilli, A., Lombardo, F., Maltoni, G., Marigliano, M., Bassi, M., Minuto, N., Mozzillo, E., Rabbone, I., Rapini, N., Rigamonti, A., Salzano, G., Scaramuzza, A., Schiaffini, R., Tinti, D., Toni, S., Zagaroli, L., Zucchini, S., Maffeis, C., Gesuita, R.
بيانات النشر: Mary Ann Liebert Inc., 2020.
سنة النشر: 2020
مصطلحات موضوعية: Blood Glucose, Male, Insulin glulisine, Insulin degludec, medicine.medical_specialty, Coefficient of variation, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Time above range, %, Time below range, Real-world evaluation, Time in range, 030209 endocrinology & metabolism, Insulin aspart, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Endocrinology, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Insulin lispro, 030212 general & internal medicine, Child, Glycated Hemoglobin, Blood glucose monitoring, Type 1 diabetes, medicine.diagnostic_test, business.industry, Insulin glargine, Blood Glucose Self-Monitoring, medicine.disease, Medical Laboratory Technology, Cross-Sectional Studies, Diabetes Mellitus, Type 1, %, Emergency medicine, Time above range, Female, business, medicine.drug
الوصف: Background: Glucose sensors consist of real-time continuous glucose monitoring (rtCGM) and intermittently scanned CGM (isCGM). Their clinical use has been widely increasing during the past 5 years. The aim of this study is to evaluate percentage of time in range (TIR) in a large group of children with type 1 diabetes (T1D) using glucose sensors with nonautomated insulin delivery systems, in a real-world setting. Methods: An 11-center cross-sectional study was conducted during January-May 2019. Children with T1D 1 year, treated with multiple daily injections (MDI) or nonautomated insulin pump (IP), were recruited consecutively. Clinical data, HbA1c measurement, and CGM downloaded data were collected by each center and included in a centralized database for the analysis. Glucose metrics of four treatment strategies were analyzed: isCGM-MDI, rtCGM-MDI, isCGM-IP, and rtCGM-IP. Results: Data from 666 children with T1D (51% male and 49% female), median age 12 years, diabetes duration 5 years, were analyzed. An rtCGM was used by 51% of the participants, and a nonautomated IP by 46%. For isCGM-MDI, rtCGM-MDI, isCGM-IP, and rtCGM-IP, the median TIR 70-180 mg/dL values were 49%, 56%, 56%, and 61% (P < 0.001), respectively; HbA1c 7.6%, 7.5%, 7.3%, and 7.3% (P < 0.001), respectively. Use of rtCGM was associated with significant lower time below target range 180 mg/dL and lower HbA1c. If there are no barriers, an upgrade of the treatment strategy with a higher performing technology should be offered to all children who do not achieve blood glucose metrics within the suggested range.
اللغة: English
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4c5aa116b9077a8bda0c859ef9ee80Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....2e4c5aa116b9077a8bda0c859ef9ee80
قاعدة البيانات: OpenAIRE
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