Transcriptional regulation of T cell tolerance
| العنوان: | Transcriptional regulation of T cell tolerance |
|---|---|
| المؤلفون: | Noemi Soto-Nieves, Sanmay Bandyopadhyay, Fernando Macian |
| المصدر: | The Epigenetics of Autoimmune Diseases |
| بيانات النشر: | Elsevier BV, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Clonal Anergy, Transcription, Genetic, Clonal anergy, T-Lymphocytes, ZAP70, T cell, Immunology, Peripheral tolerance, CD28, Biology, Article, Cell biology, Interleukin 21, medicine.anatomical_structure, Gene Expression Regulation, Immune Tolerance, medicine, Animals, Humans, Immunology and Allergy, Cytotoxic T cell, IL-2 receptor |
| الوصف: | Self-reactive T cells that escape negative selection in the thymus must be kept under control in the periphery. Mechanisms of peripheral tolerance include deletion or functional inactivation of self-reactive T cells and mechanisms of dominant tolerance mediated by regulatory T cells. In the absence of costimulation, T cell receptor (TCR) engagement results in unopposed calcium signaling that leads to the activation of a cell-intrinsic program of inactivation, which makes T cells hyporesponsive to subsequent stimulations. The activation of this program in anergic T cells is a consequence of the induction of a nuclear factor of activated T cells (NFAT)-dependent program of gene expression. Recent studies have offered new insights into the mechanisms responsible for the implementation and maintenance of T cell anergy and have provided evidence that the proteins encoded by the genes upregulated in anergic T cells are responsible for the implementation of anergy by interfering with TCR signaling or directly inhibiting cytokine gene transcription. |
| تدمد: | 1044-5323 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a4509b259908d7a7911b4539757cdTest https://doi.org/10.1016/j.smim.2007.02.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d5a4509b259908d7a7911b4539757cd |
| قاعدة البيانات: | OpenAIRE |
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