The use of proton pump inhibitors and the spectrum and number of biliary pathogens in patients with acute cholangitis
العنوان: | The use of proton pump inhibitors and the spectrum and number of biliary pathogens in patients with acute cholangitis |
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المؤلفون: | Alexander Hapfelmeier, S von Delius, Hana Algül, Nina Wantia, W. Weidner, Jochen Schneider, Roland M. Schmid, Wolfgang Huber, Andreas Weber, Bruno Neu, Susanne Feihl |
المصدر: | Alimentary Pharmacology & Therapeutics. 39:1194-1203 |
بيانات النشر: | Wiley, 2014. |
سنة النشر: | 2014 |
مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cholangitis, medicine.drug_class, medicine.medical_treatment, Antibiotics, Drug resistance, Percutaneous transhepatic cholangiography, Gastroenterology, symbols.namesake, Anti-Infective Agents, Internal medicine, Humans, Medicine, Pharmacology (medical), Poisson Distribution, Poisson regression, Aged, Retrospective Studies, Aged, 80 and over, Hepatology, business.industry, Incidence, Incidence (epidemiology), Stent, Drug Resistance, Microbial, Proton Pump Inhibitors, Retrospective cohort study, Middle Aged, Biliary tract, Acute Disease, Multivariate Analysis, symbols, Regression Analysis, Female, business |
الوصف: | Summary Background Knowledge of the bacterial spectrum for acute cholangitis is essential for adequate empiric antibiotic treatment. Aim To analyse the relation of proton pump inhibitors (PPI) with biliary pathogens in patients with acute cholangitis. Methods This retrospective study identified 278 patients with 318 acute cholangitis episodes using an endoscopic database. The relationship between PPI and microbiological outcomes was assessed by logistic and poisson regression analysis for binary and count data. Results In total, 882 pathogens were isolated, of which, 120 cholangitis episodes occurred with PPI; 198 cholangitis episodes without PPI. Multivariate poisson regression analysis showed that PPI use resulted in a 23% increase in the number of biliary pathogens [3.14 vs. 2.55 (Δ = 0.59), P |
تدمد: | 0269-2813 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf713cef4ecd861772183b61515abd4Test https://doi.org/10.1111/apt.12694Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....2cf713cef4ecd861772183b61515abd4 |
قاعدة البيانات: | OpenAIRE |
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