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Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease

التفاصيل البيبلوغرافية
العنوان:	Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease
المؤلفون:	Sanjay Misra, James F. Glockner, Stephen C. Textor, Kai Jiang, Lilach O. Lerman, Abdelrhman Abumoawad, Christopher M. Ferguson, Ahmed Saad, Alfonso Eirin, Ahmad F. Hedayat
المصدر:	Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
بيانات النشر:	Springer Science and Business Media LLC, 2020.
سنة النشر:	2020
مصطلحات موضوعية:	Male, medicine.medical_specialty, Biopsy, medicine.medical_treatment, 030232 urology & nephrology, Urology, lcsh:Medicine, Renal function, Kidney, Renal Artery Obstruction, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Angioplasty, medicine, Renal fibrosis, Humans, lcsh:Science, Aged, Creatinine, Multidisciplinary, medicine.diagnostic_test, business.industry, lcsh:R, Magnetic resonance imaging, medicine.disease, body regions, Diffusion Magnetic Resonance Imaging, Treatment Outcome, medicine.anatomical_structure, chemistry, Female, lcsh:Q, Renal vein, business
الوصف:	Tissue fibrosis is an important index of renal disease progression. Diffusion-weighted magnetic resonance imaging’s (DWI-MRI) apparent diffusion coefficient (ADC) reveals water diffusion is unobstructed by microstructural alterations like fibrosis. We hypothesized that ADC may indicate renal injury and response to therapy in patients with renovascular disease (RVD). RVD patients were treated with medical therapy (MT) and percutaneous transluminal renal angioplasty (MT + PTRA) (n = 11, 3 bilaterally, n = 14 kidneys) or MT (n = 9). ADC and renal hypoxia (R2*) by blood-oxygen-level-dependent MRI were studied before (n = 27) and 3 months after (n = 20) treatment. Twelve patients underwent renal biopsies. Baseline ADC values were correlated with changes in eGFR, serum creatinine (SCr), systolic blood pressure (SBP), renal hypoxia, and renal vein levels of pro-inflammatory marker tumor necrosis-factor (TNF)-α. Renal oxygenation, eGFR, and SCr improved after MT + PTRA. ADC inversely correlated with the histological degree of renal fibrosis, but remained unchanged after MT or MT + PTRA. Basal ADC values correlated modestly with change in SBP, but not in renal hypoxia, TNF-α levels, or renal function. Lower ADC potentially reflects renal injury in RVD patients, but does not change in response to medical or interventional therapy over 3 months. Future studies need to pinpoint indices of kidney recovery potential.
تدمد:	2045-2322
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d73121746693e049b8e0d60e96ed9beTest https://doi.org/10.1038/s41598-020-73202-0Test
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....1d73121746693e049b8e0d60e96ed9be
قاعدة البيانات:	OpenAIRE

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Diffusion-weighted magnetic resonance imaging’s (DWI-MRI) apparent diffusion coefficient (ADC) reveals water diffusion is unobstructed by microstructural alterations like fibrosis. We hypothesized that ADC may indicate renal injury and response to therapy in patients with renovascular disease (RVD). RVD patients were treated with medical therapy (MT) and percutaneous transluminal renal angioplasty (MT + PTRA) (n = 11, 3 bilaterally, n = 14 kidneys) or MT (n = 9). ADC and renal hypoxia (R2*) by blood-oxygen-level-dependent MRI were studied before (n = 27) and 3 months after (n = 20) treatment. Twelve patients underwent renal biopsies. Baseline ADC values were correlated with changes in eGFR, serum creatinine (SCr), systolic blood pressure (SBP), renal hypoxia, and renal vein levels of pro-inflammatory marker tumor necrosis-factor (TNF)-α. Renal oxygenation, eGFR, and SCr improved after MT + PTRA. 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