Permanently reduced plasma ionized magnesium among renal transplant recipients on cyclosporine
العنوان: | Permanently reduced plasma ionized magnesium among renal transplant recipients on cyclosporine |
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المؤلفون: | Simone D. P. Vannini, Bendicht Wermuth, Paolo Ferrari, Anita C. Truttmann, Luca Rodoni, Mario G. Bianchetti, Brunello L. Mazzola |
المصدر: | Transplant international : official journal of the European Society for Organ Transplantation. 12(4) |
سنة النشر: | 1999 |
مصطلحات موضوعية: | Nephrology, Adult, Male, medicine.medical_specialty, Adolescent, chemistry.chemical_element, Gastroenterology, Hypomagnesemia, Reference Values, Internal medicine, Azathioprine, medicine, Humans, Hypoglycemic Agents, Magnesium, Child, Diuretics, Magnesium ion, Kidney transplantation, Aged, Transplantation, Kidney, business.industry, Cardiovascular Agents, Middle Aged, Mycophenolic Acid, Ciclosporin, medicine.disease, Kidney Transplantation, medicine.anatomical_structure, Endocrinology, chemistry, Cyclosporine, Prednisone, Female, business, Immunosuppressive Agents, medicine.drug, Follow-Up Studies |
الوصف: | Hypomagnesemia is common after kidney transplantation. Until recently, only the determination of total plasma magnesium was possible, whereas the assessment of ionized magnesium has since become practicable. One hundred and nine renal transplant patients on cyclosporine with allografts functioning stably for more than 6 months and plasma creatinine levels of less than 200 micromol/l entered the study. Total and ionized circulating magnesium were assessed among these 109 patients, as well as among 15 renal transplant patients not on cyclosporine and 21 healthy volunteers. Cyclosporine patients showed significantly lower total and ionized circulating magnesium values than the two control groups. Plasma total and ionized magnesium levels were also significantly lower among cyclosporine patients treated concurrently with insulin or oral hypoglycemic agents than among those who were not. No correlation was noted between time after transplantation and plasma magnesium with respect to patients on cyclosporine. In conclusion, the study demonstrates that a large subset of renal transplant patients treated with cyclosporine have permanent deficiencies of ionized and total magnesium. The tendency towards hypomagnesemia is also more pronounced among patients with diabetes mellitus. |
تدمد: | 0934-0874 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7f79ea0813f90e6921f6504778125Test https://pubmed.ncbi.nlm.nih.gov/10460868Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....1ba7f79ea0813f90e6921f6504778125 |
قاعدة البيانات: | OpenAIRE |
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