Conventional protein kinase C in the brain: 40 years later
| العنوان: | Conventional protein kinase C in the brain: 40 years later |
|---|---|
| المؤلفون: | Julia A. Callender, Alexandra C. Newton |
| المصدر: | Neuronal Signaling |
| بيانات النشر: | Portland Press Ltd., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, Biology, Molecular Bases of Health & Disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Review Articles, Loss function, Protein kinase C, Diacylglycerol kinase, chemistry.chemical_classification, posttranslational modification, Post-Translational Modifications, Molecular Interactions, Neurodegeneration, neurodegeneration, Cancer, Alzheimer's disease, medicine.disease, Cell biology, 030104 developmental biology, Enzyme, chemistry, Mutation, 030217 neurology & neurosurgery, Neuroscience, protein kinase C |
| الوصف: | Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids. While PKC has been widely implicated in the pathology of diseases affecting all areas of physiology including cancer, diabetes, and heart disease—it was discovered, and initially characterized, in the brain. PKC plays a key role in controlling the balance between cell survival and cell death. Its loss of function is generally associated with cancer, whereas its enhanced activity is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca2+-sensitive conventional PKC isozymes in neurodegeneration. |
| تدمد: | 2059-6553 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1961077473400d72c05372787f79392eTest https://doi.org/10.1042/ns20160005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1961077473400d72c05372787f79392e |
| قاعدة البيانات: | OpenAIRE |
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